Title

Comparison of iodine-125-BMIPP and thallium-201 in myocardial hypoperfusion

UMMS Affiliation

Department of Radiology, Division of Nuclear Medicine

Publication Date

9-1-1995

Document Type

Article

Subjects

Animals; Autoradiography; *Coronary Circulation; Decanoic Acids; *Fatty Acids; Heart; Iodine Radioisotopes; Iodobenzenes; Male; Myocardial Ischemia; Myocardium; Rabbits; Thallium Radioisotopes

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Radiolabeled fatty acids such as 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) have unique metabolic properties of potential use as myocardial perfusion tracers. Accordingly, we compared the in vivo pattern of uptake of BMIPP and 201Tl in hypoperfused rabbit myocardium. METHODS: Animals were intubated, ventilated and their arterial pressures monitored. A left thoracotomy was performed. After ligation of a major branch of the circumflex artery, an intravenous injection of BMIPP or BMIPP/201TI was given. Radiolabeled microspheres were used to document the area of risk. After the circulation period, the animals were killed. Tracer deposition within the hearts was determined by either dual-tracer autoradiography (Protocol I) or by segmental tissue analysis (Protocol II). RESULTS: Dual-tracer autoradiographic activity profiles for BMIPP were comparable to those of 201TI. Moreover, the two tracers yielded similar values for normal-to-defect contrast and defect size. The myocardial activity concentration of BMIPP for both protocols correlated strongly with coronary blood flow and compared favorably with 201TI. CONCLUSION: BMIPP and 201TI accurately delineate areas of hypoperfusion distal to a coronary occlusion. Therefore, differences in the myocardial distribution of BMIPP and 201TI in clinical studies may be related to cellular fatty acid metabolism.

Rights and Permissions

Citation: J Nucl Med. 1995 Sep;36(9):1645-53.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

PubMed ID

7658226