HIV-1 replication increases HIV-specific CD4+ T cell frequencies but limits proliferative capacity in chronically infected children
Authors
Scott, Zachary AaronBeaumier, Coreen Michele
Sharkey, Mark E.
Stevenson, Mario
Luzuriaga, Katherine
UMass Chan Affiliations
Program in Molecular MedicineDepartment of Pediatrics
Graduate Program in Immunology/Virology
Document Type
Journal ArticlePublication Date
2003-05-22Keywords
AdolescentAdult
CD4-Positive T-Lymphocytes
Cell Division
Child
Child, Preschool
Chronic Disease
Cytomegalovirus
Down-Regulation
Epitopes, T-Lymphocyte
Gene Dosage
Gene Products, gag
HIV Infections
HIV-1
Humans
Infant
Interferon Type II
Lymphocyte Activation
Lymphocyte Count
Lymphopenia
Phosphoproteins
Protein Precursors
Viral Load
Viral Matrix Proteins
Virus Replication
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
This study investigated the relationship between HIV-1 replication and virus (HIV-1; CMV)-specific CD4(+) T cell frequency and function in HIV-1-infected children. HIV-1 gag p55-specific CD4(+) T cell IFN-gamma responses were detected in the majority of children studied. p55-specific responses were detected less commonly and at lower frequencies in children with/ml plasma HIV-1 RNA than in children with active HIV-1 replication. In children with/ml plasma HIV-1, p55-specific responses were detected only in children with evidence of ongoing HIV-1 replication, indicating a direct relationship between HIV-1 replication and HIV-specific CD4(+) T cell frequencies. In contrast, p55-specific proliferative responses were detected more frequently in children with/ml plasma HIV-1. CMV-specific CD4(+) responses were more commonly detected and at higher frequencies in CMV-coinfected children with suppressed HIV-1 replication. The lack of HIV-specific CD4(+) proliferative responses, along with the preservation of CMV-specific CD4(+) responses in children with controlled HIV-1 replication, suggests that viral replication may have deleterious effects on HIV-1 and other virus-specific CD4(+) responses. Vaccination to stimulate HIV-specific CD4(+) T cell responses in these children may synergize with antiretroviral therapy to improve the long-term control of viral replication, and may perhaps allow the eventual discontinuation of antiretroviral therapy.Source
J Immunol. 2003 Jun 1;170(11):5786-92.
DOI
10.4049/jimmunol.170.11.5786Permanent Link to this Item
http://hdl.handle.net/20.500.14038/38235PubMed ID
12759463Related Resources
ae974a485f413a2113503eed53cd6c53
10.4049/jimmunol.170.11.5786