Title

Tartrate-resistant acid phosphatase in mononuclear and multinuclear cells during the bone resorption of tooth eruption

UMMS Affiliation

Department of Anatomy

Publication Date

11-1-1987

Document Type

Article

Subjects

Acid Phosphatase; Alveolar Process; Animals; *Bone Resorption; Dental Sac; Dogs; Histocytochemistry; Osteoclasts; Tartrates; *Tooth Eruption

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Tartrate-resistant acid phosphatase (TRAP) has been used as a cytochemical marker for the cell mediators of bone resorption, osteoclasts and their mononuclear precursors. We have applied a cytochemical method for TRAP to study the dependence of the osteoclast-mediated bone resorption of tooth eruption on the dental follicle, a connective tissue investment of the developing tooth, by analyzing the TRAP activity of mononuclear cells in the dental follicle before and during pre-molar eruption in dogs. The percentage of TRAP-positive monocyte cells increases until mid-eruption, slightly preceding a previously demonstrated rise in numbers of osteoclasts on adjacent bone surfaces. These data suggest an ontogenetic relationship between follicular mononuclear cells and osteoclasts on adjacent alveolar bone surfaces during tooth eruption. However, because TRAP occurs in other tissues and is not an exclusive indicator of pre-osteoclasts, proof of their relationship will have to await application of more definitive techniques.

Rights and Permissions

Citation: J Histochem Cytochem. 1987 Nov;35(11):1227-30.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

PubMed ID

3655324