Title

Cell surface receptors, virus entry and tropism of primate lentiviruses

UMMS Affiliation

Center for AIDS Research; Program in Molecular Medicine

Publication Date

7-19-2002

Document Type

Article

Subjects

Animals; HIV Infections; HIV-1; Humans; Lentivirus; Receptors, Cell Surface; Receptors, HIV; Receptors, Virus

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Human immunodeficiency virus (HIV) exploits cell surface receptors to attach to and gain entry into cells. The HIV envelope spike glycoprotein on the surface of virus particles binds both CD4 and a seven-transmembrane coreceptor. These interactions trigger conformational changes in the envelope spike that induce fusion of viral and cellular membranes and entry of the viral core into the cell cytoplasm. Other cell surface receptors also interact with gp120 and aid attachment of virus particles. This review describes these receptors, their roles in HIV entry and their influence on cell tropism.

Rights and Permissions

Citation: J Gen Virol. 2002 Aug;83(Pt 8):1809-29.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

The Journal of general virology

PubMed ID

12124446