Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2017

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Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study, Adeyinka Adejumo, Samson Alliu, Tokunbo Opeyemi Ajayi, Kelechi Lauretta Adejumo, Oluwole Muyiwa Adegbala, Nnaemeka Egbuna Onyeakusi, Akintunde Micheal Akinjero, Modupeoluwa Durojaiye, and Terence N. Bukong

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Defining the 5 and 3 landscape of the Drosophila transcriptome with Exo-seq and RNaseH-seq, Shaked Afik, Osnat Bartok, Maxim N. Artyomov, Alexander A. Shishkin, Sabah Kadri, Mor Hanan, Xiaopeng Zhu, Manuel Garber, and Sebastian Kadener

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Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery, Jianzhong Ai, Jia Li, Dominic J. Gessler, Qin Su, Qiang Wei, Hong Li, and Guangping Gao

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Evaluation of the impact of a prescribing guideline on the use of intraoperative dexmedetomidine at a tertiary academic medical center, Abdullah M. Alhammad, Nour A. Baghdady, Rachel A. Mullin, and Bonnie C. Greenwood

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Staying afloat in a sea of information: Point-of-care resources, Rebecca Andrews, Neil Mehta, Jack Maypole, and Stephen A. Martin

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Nucleosomes influence multiple steps during replication initiation, Ishara F. Azmi, Shinya Watanabe, Michael F. Maloney, Sukhyun Kang, Jason A. Belsky, David M. MacAlpine, Craig L. Peterson, and Stephen P. Bell

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A National CERA Study of the Use of Laborists in Family Medicine Residency Training, Robert A. Baldor, Christine Chang Pecci, Gerardo Moreno, Virginia Van Duyne, and Stacy E. Potts

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Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior, Navonil Banerjee, Raja Bhattacharya, Michael Gorczyca, Kevin M. Collins, and Michael M. Francis

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BALB/c mice immunized with a combination of virus-like particles incorporating Kaposi sarcoma-associated herpesvirus (KSHV) envelope glycoproteins gpK8.1, gB, and gH/gL induced comparable serum neutralizing antibody activity to UV-inactivated KSHV, Anne K. Barasa, Peng Ye, Meredith Phelps, Ganapathiram T. Arivudainambi, Timelia Tison, and Javier Gordon Ogembo

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Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit, Belinda Barbagallo, Alison Philbrook, Denis Touroutine, Navonil Banerjee, Devyn Oliver, Christopher M. Lambert, and Michael M. Francis

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Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality, David Beauparlant, Peter Rusert, Carsten Magnus, Claus Kadelka, Jacqueline Weber, Therese Uhr, Osvaldo Zagordi, Corinna Oberle, Maria J. Duenas-Decamp, Paul R. Clapham, Karin J. Metzner, Huldrych F. Gunthard, and Alexandra Trkola

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A Circulating microRNA Signature Predicts Age-Based Development of Lymphoma, Afshin Beheshti, Charles Vanderburg, J. Tyson McDonald, Charusheila Ramkumar, Tatenda Kadungure, Hong Zhang, Ronald B. Gartenhaus, and Andrew M. Evens

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HMGB1, IL-1alpha, IL-33 and S100 proteins: dual-function alarmins, Damien Bertheloot and Eicke Latz

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Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans, Cassandra R. Blanchette, Andrea Thackeray, Paola N. Perrat, Siegfried Hekimi, and Claire Y. Benard

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Virtual Patient Technology: Engaging Primary Care in Quality Improvement Innovations, Amanda C. Blok, Christine N. May, Rajani S. Sadasivam, and Thomas K. Houston

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The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis, Cordula M. Boehm, Samson Obado, Catarina Gadelha, Alexandra Kaupisch, Paul T. Manna, Gwyn W. Gould, Mary Munson, Brian T. Chait, Michael P. Rout, and Mark C. Field

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"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report, Cesar Boggiano, Katrin Eichelberg, Lakshmi Ramachandra, Jaqueline Shea, Lalita Ramakrishnan, Samuel M. Behar, Joel D. Ernst, Steven A. Porcelli, Markus Maeurer, and Hardy Kornfeld

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Krill Oil-In-Water Emulsion Protects against Lipopolysaccharide-Induced Proinflammatory Activation of Macrophages In Vitro, Gabriel A. Bonaterra, David F. Driscoll, Hans Schwarzbach, and Ralf Kinscherf

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Soluble Uric Acid Activates the NLRP3 Inflammasome, Tarcio Teodoro Braga, Maria Fernanda Forni, Matheus Correa-Costa, Rodrigo Nalio Ramos, Jose Alexandre Barbuto, Paola Branco, Angela Castoldi, Meire Ioshie Hiyane, Mariana Rodrigues Davanso, Eicke Latz, Bernardo S. Franklin, Alicia J. Kowaltowski, and Niels Olsen Saraiva Camara

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Characterization of a new oda3 allele, oda3-6, defective in assembly of the outer dynein arm-docking complex in Chlamydomonas reinhardtii, Jason M. Brown, Matthew Mosley, Daniela Montes-Berrueta, Yuqing Hou, Fan Yang, Chasity Scarbrough, George B. Witman, and Maureen Wirschell

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IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium, Jason M. Brown, Tyler Picariello, Deborah A. Cochran, George B. Witman, and Karl Lechtreck

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Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes, Ange-Line Bruel, Thibaut Eguether, Gregory J. Pazour, and Christel Thauvin-Robinet

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Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial, Gerd R. Burmester, William F. Rigby, Ronald F. van Vollenhoven, Jonathan Kay, Andrea Rubbert-Roth, Ricardo Blanco, Alysha Kadva, and Sophie Dimonaco

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Behavioral activation for smoking cessation and mood management following a cardiac event: results of a pilot randomized controlled trial, Andrew Busch, Erin M. Tooley, Shira Dunsiger, Elizabeth A. Chattillion, John Fani Srour, Sherry L. Pagoto, Christopher W. Kahler, and Belinda Borrelli

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Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis, Carmelo Carmona-Rivera, Paul R. Thompson, and Mariana J. Kaplan

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Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue, Carly T. Cederquist, Claudia Lentucci, Camila Martinez Calejman, Vanessa Hayashi, Joseph Orofino, David A. Guertin, Susan K. Fried, Mi-Jeong Lee, M. Dafne Cardamone, and Valentina Perissi

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High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection, Alper Celik, Richard E. Baker, Feng He, and Allan Jacobson

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A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification, Can Cenik, Hon Nian Chua, Guramrit Singh, Abdalla Akef, Michael P. Snyder, Alexander F. Palazzo, Melissa J. Moore, and Frederick P. Roth

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Augmenting the anisotropic network model with torsional potentials improves PATH performance, enabling detailed comparison with experimental rate data, Srinivas Niranj Chandrasekaran and Charles W. Carter Jr

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An SMC-like protein binds and regulates Caenorhabditis elegans condensins, Lucy Fang-I Chao, Meha Singh, James Thompson, John R. Yates 3rd, and Kirsten A. Hagstrom

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Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis, Catherine Y. Cheng, Nuria M. Martinez, Kim West, Hardy Kornfeld, and Amit Singhal

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HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans, Huan-Da Chen, Raffi V. Aroian, and Chang-Shi Chen

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JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21, B. Colleoni, S. Paternot, J. M. Pita, X. Bisteau, K. Coulonval, Roger J. Davis, E. Raspe, and P. P. Roger

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The 2016 Model of the Clinical Practice of Emergency Medicine, Francis L. Counselman, Kavita Babu, Mary Ann. Edens, Diane L. Gorgas, Cherri Hobgood, Catherine A. Marco, Eric Katz, Kevin Rodgers, Leonard A. Stallings, Michael C. Wadman, Michael S. Beeson, Julia N. Keehbauch, and American Board of Emergency Medicine

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Effect of transcription factor resource sharing on gene expression noise, Dipjyoti Das, Supravat Dey, Robert C. Brewster, and Sandeep Choubey (PLoS computational biology, 4-17-2017)

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Melanoma mystery, Roger J. Davis

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Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis, Michael A. DeJesus, Elias R. Gerrick, Weizhen Xu, Sae Woong. Park, Jarukit E. Long, Cara C. Boutte, Eric J. Rubin, Dirk Schnappinger, Sabine Ehrt, Sarah M. Fortune, Christopher M. Sassetti, and Thomas R. Ioerger

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Statistical analysis of genetic interactions in Tn-Seq data, Michael A. DeJesus, Subhalaxmi Nambi, Clare M. Smith, Richard E. Baker, Christopher M. Sassetti, and Thomas R. Ioerger

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Mechanism of ribosome rescue by ArfA and RF2, Gabriel Demo, Egor Svidritskiy, Rohini Madireddy, Ruben Diaz-Avalos, Timothy Grant, Nikolaus Grigorieff, Duncan Sousa, and Andrei A. Korostelev

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Diagnostic performance and optimal cut-off scores of the Massachusetts youth screening instrument-second version in a sample of Swiss youths in welfare and juvenile justice institutions, Claudia Dolitzsch, Laura E. W. Leenarts, Klaus Schmeck, Jorg M. Fegert, Thomas Grisso, and Marc Schmid

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Evidence of potential bias in a comparison of beta blockers and calcium channel blockers in patients with chronic obstructive pulmonary disease and acute coronary syndrome: results of a multinational study, Yaa-Hui Dong, Matthew Alcusky, Vittorio Maio, Jun Liu, Mengdan Liu, Li-Chiu Wu, Chia-Hsuin Chang, Mei-Shu Lai, and Joshua J. Gagne

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An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5, Ly-Sha Ee, Kurtis N. McCannell, Yang Tang, Nancy Fernandes, W. Rod Hardy, Michael R. Green, Feixia Chu, and Thomas G. Fazzio

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Clinical application of a cancer genomic profiling assay to guide precision medicine decisions, Cheryl Eifert, Angeliki Pantazi, Ruobai Sun, Jia Xu, Pablo Cingolani, Joerg Heyer, Meaghan Russell, Maria Lvova, Jennifer Ring, Julie Y. Tse, Stephen Lyle, and Alexei Protopopov

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A systematic review and meta-analysis on herpes zoster and the risk of cardiac and cerebrovascular events, Nathaniel Erskine, Hoang Tran, Len L. Levin, Christine M. Ulbricht, Joyce D. Fingeroth, Catarina I. Kiefe, Robert J. Goldberg, and Sonal Singh

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A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD, Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown Jr., Michael Benatar, Claes Wahlestedt, Christian Mueller, and Zane Zeier

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Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease, Caitlin E. Fogarty and Andreas Bergmann

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Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization, G. G. Fouda, J. Eudailey, E. L. Kunz, J. D. Amos, B. E. Liebl, J. Himes, F. Boakye-Agyeman, K. Beck, Anthony J. Michaels, M. Cohen-Wolkowiez, B. F. Haynes, Keith A. Reimann, and S. R. Permar

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Important patient characteristics differ prior to total knee arthroplasty and total hip arthroplasty between Switzerland and the United States, Patricia D. Franklin, Hermes Miozzari, Panayiotis Christofilopoulos, Pierre Hoffmeyer, David C. Ayers, and Anne Lubbeke

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alpha-Gal Nanoparticles in Wound and Burn Healing Acceleration, Uri Galili

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Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation, Josephine R. Giles, Adriana Turqueti Neves, Ann Marshak-Rothstein, and Mark J. Shlomchik

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Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma, Evelyn V. Santos Guerra, Chrono K. Lee, Charles A. Specht, Bhawna Yadav, Haibin Huang, Ali Akalin, Jun R. Huh, Christian Mueller, and Stuart M. Levitz

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Dimorphic cocoons of the cecropia moth (Hyalophora cecropia): Morphological, behavioral, and biophysical differences, Patrick A. Guerra and Steven M. Reppert

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Intracranial AAV-IFN-beta gene therapy eliminates invasive xenograft glioblastoma and improves survival in orthotopic syngeneic murine model, Dwijit Guhasarkar, James Neiswender, Qin Su, Guangping Gao, and Miguel Sena-Esteves

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Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies, Lisa L. Hall, Meg Byron, Dawn M. Carone, Troy W. Whitfield, Gayle P. Pouliot, Andrew H. Fischer, Peter L. Jones, and Jeanne B. Lawrence

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Sex differences in gout characteristics: tailoring care for women and men, Leslie R. Harrold, Carol J. Etzel, Allan Gibofsky, Joel Kremer, Michael H. Pillinger, Kenneth G. Saag, Naomi Schlesinger, Robert Terkeltaub, Vanessa Cox, and Jeffrey D. Greenberg

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Fluoroscopic imaging overestimates the screw tip to subchondral bone distance in a cadaveric model of slipped capital femoral epiphysis, Michael J. Heffernan, B. Snyder, H. Zhou, and X. Li

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The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain, Brendan J. Hilbert, Janelle A. Hayes, Nicholas P. Stone, Rui-Gang Xu, and Brian A. Kelch

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Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition, Deli Hong, Terri L. Messier, Coralee E. Tye, Jason Dobson, Andrew J. Fritz, Kenneth R. Sikora, Gillian Browne, Janet L. Stein, Jane B. Lian, and Gary S. Stein

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Development of a Reporter System for In Vivo Monitoring of gamma-Secretase Activity in Drosophila, Young Gi Hong, Seyun Roh, Donggi Paik, and Sangyun Jeong

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Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration, Sachi Horibata, Katherine E. Rogers, David Sadegh, Lynne J. Anguish, John L. McElwee, Pragya Shah, Paul R. Thompson, and Scott A. Coonrod

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The N-terminus of IFT46 mediates intraflagellar transport of outer arm dynein and its cargo-adaptor ODA16, Yuqing Hou and George B. Witman

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Global increase in replication fork speed during a p57KIP2-regulated erythroid cell fate switch, Yung Hwang, Melinda Futran, Daniel Hidalgo, Ramona Pop, Divya Ramalingam Iyer, Ralph Scully, Nicholas R. Rhind, and Merav Socolovsky

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The Intra-S Checkpoint Responses to DNA Damage, Divya Ramalingam Iyer and Nicholas R. Rhind

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The Sodium Channel beta4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons, Xincai Ji, Sucharita Saha, Guangping Gao, Amy W. Lasek, Gregg E. Homanics, Melissa Guildford Derner, Andrew R. Tapper, and Gilles E. Martin

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Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies, Roby Joehanes, Kahraman Tanriverdi, Jane E. Freedman, and Peter J. Munson

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Large family cohorts of lymphoblastoid cells provide a new cellular model for investigating facioscapulohumeral muscular dystrophy, Takako I. Jones, Charis L. Himeda, Daniel P. Perez, and Peter L. Jones

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An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways, Hatem E. Kamber Kaya, Mark Ditzel, Pascal Meier, and Andreas Bergmann

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AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy, Motohiro Kano, Amanda E. Sosulski, LiHua Zhang, Hatice D. Saatcioglu, Dan Wang, Nicholas Nagykery, Mary E. Sabatini, Guangping Gao, Patricia K. Donahoe, and David Pepin

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Diverse stimuli engage different neutrophil extracellular trap pathways, Elaine F. Kenny, Alf Herzig, Renate Krüger, Aaron Muth, Santanu Mondal, Paul R. Thompson, Volker Brinkmann, Horst Von Bernuth, and Arturo Zychlinsky

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Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments, Robert W. Kensler, Roger Craig, and Richard L. Moss

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Narrowing in on the anti-beta cell-specific T cells: looking 'where the action is', Sally C. Kent and Jenny Aurielle B. Babon

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Alberta Stroke Program Early CT Score Infarct Location Predicts Outcome Following M2 Occlusion, Muhib Khan, Grayson L. Baird, Richard P. Goddeau, Brian Silver, and Nils Henninger

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The chemical evolution of oligonucleotide therapies of clinical utility, Anastasia Khvorova and Jonathan K. Watts

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Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine, Cha San Koh, Rohini Madireddy, Timothy J. Beane, Phillip D. Zamore, and Andrei A. Korostelev

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Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography, Nicole Koulisis, Alice Y. Kim, Zhongdi Chu, Anoush Shahidzadeh, Bruce Burkemper, Lisa C. Olmos de Koo, Andrew A. Moshfeghi, Hossein Ameri, Carmen A. Puliafito, Veronica L. Isozaki, Ruikang K. Wang, and Amir H. Kashani

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Recreational Physical Activity and Premenstrual Syndrome in Young Adult Women: A Cross-Sectional Study, Aimee R. Kroll-Desrosiers, Alayne G. Ronnenberg, Sofija E. Zagarins, Serena C. Houghton, Biki B. Takashima-Uebelhoer, and Elizabeth R. Bertone-Johnson

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Setting the (Scientific) Record Straight: Molecular and Cellular Biology Responds to Postpublication Review, Amy L. Kullas and Roger J. Davis

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The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis, Kyung J. Kwon-Chung, Stuart M. Levitz, and Arturo Casadevall

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A hemodialysis cohort study of protocol-based anticoagulation management, Steven Lamontagne, Tinzar Basein, Binyue Chang, and Lakshmi Mallela

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Self-consistent theory of transcriptional control in complex regulatory architectures, Jasper Landman, Robert C. Brewster, Franz M. Weinert, Rob Phillips, and Willem K. Kegel (PloS one, 7-7-2017)

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mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors, Jungmin Lee, Brad Dykstra, Joel A. Spencer, Laurie L. Kenney, Dale L. Greiner, Leonard D. Shultz, Michael A. Brehm, Charles P. Lin, Robert Sackstein, and Derrick J. Rossi

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Inhibition or Stimulation of Autophagy Affects Early Formation of Lipofuscin-Like Autofluorescence in the Retinal Pigment Epithelium Cell, Lei Lei, Radouil T. Tzekov, Huapeng Li, J. Hugh McDowell, Guangping Gao, W. Clay Smith, Shibo Tang, and Shalesh Kaushal

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Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension, Yeong Hann Ling, Shalini M. Krishnan, Christopher T. Chan, Henry Diep, Dorota Ferens, Jaye Chin-Dusting, Barbara K. Kemp-Harper, Chrishan S. Samuel, Timothy D. Hewitson, Eicke Latz, Ashley Mansell, Christopher G. Sobey, and Grant R. Drummond

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Methylome-wide Association Study of Atrial Fibrillation in Framingham Heart Study, Honghuang Lin, Xiaoyan Yin, Zhijun Xie, Kathryn L. Lunetta, Steven A. Lubitz, Martin G. Larson, Darae Ko, Jared W. Magnani, Michael M. Mendelson, Chunyu Liu, David D. McManus, Daniel Levy, Patrick T. Ellinor, and Emelia J. Benjamin

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Value of circulating cell-free DNA analysis as a diagnostic tool for breast cancer: a meta-analysis, Ziqiang Lin, James Neiswender, Bin Fang, Xuelei Ma, Jing Zhang, and Xiuying Hu

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Structural Analysis of the Glycosylated Intact HIV-1 gp120-b12 Antibody Complex Using Hydroxyl Radical Protein Footprinting, Xiaoyan Li, Oliver C. Grant, Keigo Ito, Aaron Wallace, Shixia Wang, Peng Zhao, Lance Wells, Shan Lu, Robert J. Woods, and Joshua S. Sharp

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Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice, Patrick Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Karen Kodys, Donna Catalano, Doyle V. Ward, and Gyongyi Szabo

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Visualization of self-delivering hydrophobically modified siRNA cellular internalization, Socheata Ly, Deanna M. Navaroli, Marie-Claire Didiot, James Cardia, Lakshmipathi Pandarinathan, Julia F. Alterman, Kevin E. Fogarty, Clive Standley, Lawrence Lifshitz, Karl D. Bellve, Matthieu Prot, Dimas Echeverria, Silvia Corvera, and Anastasia Khvorova

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Use of distal perfusion in peripheral extracorporeal membrane oxygenation, George Makdisi, Tony Makdisi, and I-Wen Wang

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Extra corporeal membrane oxygenation support: ethical dilemmas, Tony Makdisi and George Makdisi

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A predictive model for lack of partial clinical remission in new-onset pediatric type 1 diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, and Benjamin U. Nwosu

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The p150N domain of chromatin assembly factor-1 regulates Ki-67 accumulation on the mitotic perichromosomal layer, Timothy D. Matheson and Paul D. Kaufman

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Patient Use of Electronic Prescription Refill and Secure Messaging and Its Association With Undetectable HIV Viral Load: A Retrospective Cohort Study, D. Keith McInnes, Stephanie L. Shimada, Amanda M. Midboe, Kim M. Nazi, Shibei Zhao, Justina Wu, Casey M. Garvey, and Thomas K. Houston

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Messenger RNA and MicroRNA transcriptomic signatures of cardiometabolic risk factors, David D. McManus, Jian Rong, Tianxiao Huan, Sean Lacey, Kahraman Tanriverdi, Peter J. Munson, Martin G. Larson, Roby Joehanes, Venkatesh Murthy, Ravi Shah, Jane E. Freedman, and Daniel Levy

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Screening of TNFalpha, IL-10 and TLR4 single nucleotide polymorphisms in individuals with asymptomatic and chronic cutaneous leishmaniasis in Colombia: a pilot study, Angelica Mera-Ramirez, Andres Castillo, Yenifer Orobio, Maria Adelaida. Gomez, and Carolina Gallego-Marin

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Can a nanoparticle that mimics Salmonella effectively combat tumor chemotherapy resistance, Regino Mercado-Lubo and Beth A. McCormick

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Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells, James R. C. Miller, Edith L. Pfister, Wanzhao Liu, Ralph Andre, Ulrike Trager, Lori A. Kennington, Kimberly Lo, Sipke Dijkstra, Douglas Macdonald, Gary R. Ostroff, Neil Aronin, and Sarah J. Tabrizi

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Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair, Kenta Moriwaki, Sakthi Balaji, John Bertin, Peter J. Gough, and Francis Ka-Ming Chan

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CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion, Haiwei Mou, Jordan L. Smith, Lingtao Peng, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Deniz M. Ozata, Yingxiang Li, Charles P. Emerson Jr., Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, and Wen Xue

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Culturally adaptive storytelling intervention versus didactic intervention to improve hypertension control in Vietnam: a cluster-randomized controlled feasibility trial, Hoa L. Nguyen, Jeroan J. Allison, Duc A. Ha, German Chiriboga, Ha N. Ly, Hanh T. Tran, Cuong K. Nguyen, Diem M. Dang, Ngoc T. Phan, Nguyen C. Vu, Quang P. Nguyen, and Robert J. Goldberg