This collection includes articles from open access journals authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School. Many were collected from PubMed Central, the National Institute of Health's free digital archive of biomedical and life sciences journal literature. Open access literature is "digital, online, free of charge, and free of most copyright and licensing restrictions" (Peter Suber, A Very Brief Introduction to Open Access).

Submissions from 2009

CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation, David M. Burns and Joel D. Richter

Community dimensions and HPSA practice location: 30 years of family medicine training, Suzanne B. Cashman, Judith A. Savageau, Warren J. Ferguson, and Daniel H. Lasser

Enforcement of underage sales laws as a predictor of daily smoking among adolescents: a national study, Joseph R. DiFranza, Judith A. Savageau, and Kenneth E. Fletcher

Family medicine residency characteristics associated with practice in a health professions shortage area, Warren J. Ferguson, Suzanne B. Cashman, Judith A. Savageau, and Daniel H. Lasser

A Prospective Nested Case-Control Study of Dengue in Infants: Rethinking and Refining the Antibody-Dependent Enhancement Dengue Hemorrhagic Fever Model., Daniel H. Libraty, Luz P. Acosta, Veronica Tallo, Edelwisa Segubre-Mercado, Analisa Bautista, James A. Potts, Richard G. Jarman, In-Kyu Yoon, Robert V. Gibbons, Job D. Brion, and Rosario Z. Capeding

Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes., Karen Mruk and William R. Kobertz

New approaches to HIV protease inhibitor drug design II: testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors, Madhavi N. L. Nalam and Celia A. Schiffer

Lesson in a pill box: teaching about the challenges of medication adherence, Darlene M. O'Connor, Judith A. Savageau, David B. Centerbar, Kimberly N. Wamback, Jennifer S. Ingle, and Nicole J. Lomerson

Pathobiology of inflammation to cell death, Kenneth L. Rock

Symptoms of diminished autonomy over cigarettes with non-daily use, Judith A. Savageau, Paul D. Mowery, and Joseph R. DiFranza

Improving the health of diabetic patients through resident-initiated group visits, Chris Wheelock, Judith A. Savageau, Hugh Silk, and Scott Lee

Regulation of DNA replication by the S-phase DNA damage checkpoint., Nicholas Adrian Willis and Nicholas R. Rhind

Submissions from 2008

Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway, Kamna Aggarwal, Florentina Rus, Christie Vriesema-Magnuson, Deniz Erturk Hasdemir, Nicholas Paquette, and Neal S. Silverman

New wirings in the survivin networks, Dario C. Altieri

Translation factors promote the formation of two states of the closed-loop mRNP, Nadia Amrani, Shubhendu Ghosh, David A. Mangus, and Allan Jacobson

Organization and postembryonic development of glial cells in the adult central brain of Drosophila, Takeshi Awasaki, Sen-Lin Lai, Kei Ito, and Tzumin Lee

Change in leptin, body composition and other hormones around menarche--a visual representation, Linda G. Bandini, Aviva Must, Elena N. Naumova, Sarah E. Anderson, Sonia Caprio, Jennifer L. Spadano-Gasbarro, and William H. Dietz

A close association of RyRs with highly dense clusters of Ca2+-activated Cl- channels underlies the activation of STICs by Ca2+ sparks in mouse airway smooth muscle, Rongfeng Bao, Lawrence M. Lifshitz, Richard A. Tuft, Karl D. Bellve, Kevin E. Fogarty, and Ronghua ZhuGe

Anemia, blood loss, and blood transfusions in North American children in the intensive care unit, Scot T. Bateman, Jacques Lacroix, Katia Boven, Peter W. Forbes, Roger Barton, Neal J. Thomas, Brian R. Jacobs, Barry P. Markovitz, Brahm Goldstein, James H. Hanson, H. Agnes Li, and Adrienne G. Randolph

PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans, Pedro J. Batista, J. Graham Ruby, Julie M. Claycomb, H. Rosaria Chiang, Noah Fahlgren, Kristin D. Kasschau, Daniel A. Chaves, Weifeng Gu, Jessica J. Vasale, Shenghua Duan, Darryl Conte, Shujun Luo, Gary P. Schroth, James C. Carrington, David P. Bartel, and Craig C. Mello

OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides, Steven B. Bird, Tara D. Sutherland, Chip Gresham, John G. Oakeshott, Colin Scott, and Michael Eddleston

Cost-effectiveness of screening strategies for Chlamydia trachomatis using cervical swabs, urine, and self-obtained vaginal swabs in a sexually transmitted disease clinic setting, Diane R. Blake, Nancy E. Maldeis, Mathilda R. Barnes, Andrew Hardick, Thomas C. Quinn, and Charlotte A. Gaydos

Impact of Internet pharmacy regulation on opioid analgesic availability, Edward W. Boyer and James D. Wines

Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly, Kenneth Geno Campellone, Hui-Chun Cheng, Douglas Robbins, Anosha D. Siripala, Emma J. McGhie, Richard D. Hayward, Matthew D. Welch, Michael K. Rosen, Vassilis Koronakis, and John M. Leong

Screening for type 2 diabetes: Why patients who self monitor glucose might be more depressed, Lucy M. Candib

A direct comparison of research decision-making capacity: schizophrenia/schizoaffective, medically ill, and non-ill subjects, Philip J. Candilis, Kenneth E. Fletcher, Cynthia M. A. Geppert, Charles W. Lidz, and Paul S. Appelbaum

Affective incoherence: when affective concepts and embodied reactions clash, David B. Centerbar, Simone Schnall, Gerald L. Clore, and Erika D. Garvin

Regulation of ROS signal transduction by NADPH oxidase 4 localization, Kai Chen, Michael T. Kirber, Hui Xiao, Yu Yang, and John F. Keaney

Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3, Weijun Chen, Hema Srinath, Suvana S. Lam, Celia A. Schiffer, William E. Royer, and Kai Lin

Synthesis and in vitro characterization of a dendrimer-MORF conjugate for amplification pretargeting, Xiangji Chen, Shuping Dou, Guozheng Liu, Xinrong Liu, Yi Wang, Ling Chen, Mary Rusckowski, and Donald J. Hnatowich

p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein, Ya-Wen Chen, Seema Paliwal, Kyle M. Draheim, Steven R. Grossman, and Brian C. Lewis

Potent RNAi by short RNA triggers, Chia-ying Chu and Tariq M. Rana

Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine, Mary Dawn T. Co, Laura Orphin, John Cruz, Pamela P. Pazoles, Alan L. Rothman, Francis A. Ennis, and Masanori Terajima

Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency, Jessica Lynn Crowley, Tara C. Smith, Zhiyou Fang, Norio Takizawa, and Elizabeth J. Luna

Gene regulation in the third dimension, Job Dekker

Let the children be heard: lessons from studies of the early onset of tobacco addiction, Joseph R. DiFranza and Julius B. Richmond

T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't, Angela Dolganiuc and Gyongyi Szabo

Natural resistance of human immunodeficiency virus type 1 to the CD4bs antibody b12 conferred by a glycan and an arginine residue close to the CD4 binding loop, Maria J. Duenas-Decamp, Paul J. Peters, Dennis R. Burton, and Paul R. Clapham

RNA target specificity of the embryonic cell fate determinant POS-1, Brian M. Farley, John M. Pagano, and Sean P. Ryder

Costs associated with developing and implementing a computerized clinical decision support system for medication dosing for patients with renal insufficiency in the long-term care setting, Terry S. Field, Paula A. Rochon, Monica Lee, Linda Gavendo, Sujha Subramanian, Sonja Hoover, Joann L. Baril, and Jerry H. Gurwitz

Advances in Stroke 2007: introduction, Marc Fisher

Stroke and TIA: epidemiology, risk factors, and the need for early intervention, Marc Fisher

Regulating the acrosome reaction, Harvey M. Florman, Melissa K. Jungnickel, and Keith A. Sutton

The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex, John A. Follit, Jovenal T. San Agustin, Fenghui Xu, Julie A. Jonassen, Rajeev Samtani, Cecilia W. Lo, and Gregory J. Pazour

Cryptochrome mediates light-dependent magnetosensitivity in Drosophila, Robert J. Gegear, Amy L. Casselman, Scott Waddell, and Steven M. Reppert

A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene, Stephane Gobeil, Xiaochun Zhu, Charles J. Doillon, and Michael R. Green

Integrins in prostate cancer progression, Hira Lal Goel, Jing Li, Sophia Kogan, and Lucia R. Languino

Delays in seeking medical care in hospitalized patients with decompensated heart failure, Robert J. Goldberg, Jordan H. Goldberg, Sean Pruell, Jorge L. Yarzebski, Darleen M. Lessard, Frederick A. Spencer, and Joel M. Gore

Association between dietary glycemic index, glycemic load, and high-sensitivity C-reactive protein, Jennifer A. Griffith, Yunsheng Ma, Lisa Chasan-Taber, Barbara C. Olendzki, David E. Chiriboga, Edward J. Stanek, Philip A. Merriam, and Ira S. Ockene

Transcription factor functionality and transcription regulatory networks, Christian A. Grove and Albertha J. M. Walhout

A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes, G. Nana Hagan, Yenshou Lin, Mark A. Magnuson, Joseph Avruch, and Michael P. Czech

Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness, Lawrence J. Hayward, Joanna S. Kim, Ming-Yang Lee, Hongru Zhou, Ji W. Kim, Kumudini Misra, Mohammad Salajegheh, Fen-fen Wu, Shinji Matsuda, Valerie Reid, Didier Cros, Eric P. Hoffman, Jean-Marc Renaud, Stephen C. Cannon, and Robert H. Brown

Outer-membrane transport of aromatic hydrocarbons as a first step in biodegradation, Elizabeth M. Hearn, Dimki R. Patel, and Bert Van den Berg

CD40 on APCs is needed for optimal programming, maintenance, and recall of CD8+ T cell memory even in the absence of CD4+ T cell help, Maria Genevieve H. Hernandez, Lianjun Shen, and Kenneth L. Rock

Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells, Michael D. Horwich and Phillip D. Zamore

Spectrum of medium-chain acyl-CoA dehydrogenase deficiency detected by newborn screening, Ho-Wen Hsu, Thomas H. Zytkovicz, Anne Marie Comeau, Arnold W. Strauss, Deborah Marsden, Vivian E. Shih, George F. Grady, and Roger B. Eaton

Multisite phosphorylation regulates Bim stability and apoptotic activity, Anette Hubner, Tamera Barrett, Richard A. Flavell, and Roger J. Davis

Paramyxoviruses: different receptors - different mechanisms of fusion, Ronald M. Iorio and Paul J. Mahon

Overexpression of thiol/disulfide isomerases enhances membrane fusion directed by the Newcastle disease virus fusion protein, Surbhi Jain, Lori McGinnes, and Trudy G. Morrison

Role of thiol/disulfide exchange in newcastle disease virus entry, Surbhi Jain, Lori McGinnes, and Trudy G. Morrison

Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling, Vishal Jain, Annett Halle, Kristen A. Halmen, Egil Lien, Marie Charrel-Dennis, Sanjay Ram, Douglas T. Golenbock, and Alberto Visintin

Epigenetics in the nervous system, Yan Jiang, Brett Langley, Farah D. Lubin, William Renthal, Marcelo A. Wood, Dag H. Yasui, Arvind Kumar, Eric J. Nestler, Schahram Akbarian, and Andrea C. Beckel-Mitchener

An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation, Ying Jiang, Zhiliang Cheng, Elisabet C. Mandon, and Reid Gilmore

Oncofetal protein IMP3: a novel molecular marker that predicts metastasis of papillary and chromophobe renal cell carcinomas, Zhong Jiang, Christine M. Lohse, Peigou G. Chu, Chin-Lee Wu, Bruce A. Woda, Kenneth L. Rock, and Eugene D. Kwon

Head-head and head-tail interaction: a general mechanism for switching off myosin II activity in cells, HyunSuk Jung, Satoshi Komatsu, Mitsuo Ikebe, and Roger W. Craig

The safety and tolerability of an HIV-1 DNA prime-protein boost vaccine (DP6-001) in healthy adult volunteers, Jeffrey S. Kennedy, Mary Dawn T. Co, Sharone Green, Karen J. Longtine, Jaclyn K. Longtine, Melissa A. O'Neill, Janice P. Adams, Alan L. Rothman, Qiao Yu, Renita Johnson-Leva, Ranajit Pal, Shixia Wang, Shan Lu, and Phillip Markham

The effects of Tween-80 on the integrity of solutions of capsaicin: useful information for performing tussigenic challenges, Scott E. Kopec, Richard S. Irwin, Ronald J. Debellis, Mark B. Bohlke, and Timothy J. Maher

Binding of ATP to UAP56 is necessary for mRNA export, Krishna P. Kota, Stefan R. Wagner, Elvira Huerta, Jean. M. Underwood, and Jeffrey A Nickerson

Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis, Connie Wing-Ching Lee, Christopher M. Raskett, Igor Prudovsky, and Dario C. Altieri

A functional Notch-survivin gene signature in basal breast cancer, Connie Wing-Ching Lee, Karl Simin, Qin Liu, Janet Plescia, Minakshi Guha, Ashraf Khan, Chung-Cheng Hsieh, and Dario C. Altieri

Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes, Deborah Leonard, Akira Hayakawa, Deirdre C. Lawe, David G. Lambright, Karl D. Bellve, Clive Standley, Lawrence M. Lifshitz, Kevin E. Fogarty, and Silvia Corvera

Non-genomic actions of thyroid hormone in brain development, Jack L. Leonard

Fournier gangrene: role of imaging, Robin B. Levenson, Ajay K. Singh, and Robert A. Novelline

Immune system derived from homeostatic proliferation generates normal CD8 T-cell memory but altered repertoires and diminished heterologous immune responses, Sue-Jane Lin, Alex T. Chen, and Raymond M. Welsh

A NOVEL METHOD FOR TEACHING THE FIRST INSTANCES OF SIMPLE DISCRIMINATION TO NONVERBAL CHILDREN WITH AUTISM IN A LABORATORY ENVIRONMENT, Karen M. Lionello-Denolf, Romariz da Silva Barros, and William J. McIlvane

The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells, Kathryn L. Lipson, Rajarshi Ghosh, and Fumihiko Urano

BRCA-FA pathway as a target for anti-tumor drugs, Rachel Litman, Rigu Gupta, Robert M. Brosh, and Sharon B. Cantor

An experimental and theoretical evaluation of the influence of pretargeting antibody on the tumor accumulation of effector, Guozheng Liu, Shuping Dou, Mary Rusckowski, and Donald J. Hnatowich

Linking SNPs to CAG repeat length in Huntington's disease patients, Wanzhao Liu, Lori A. Kennington, H. Diana Rosas, Steven M. Hersch, Jang-Ho Cha, Phillip D. Zamore, and Neil Aronin

Should adjustment for covariates be used in prevalence estimations, Wenjun Li, Edward J. Stanek, and Elizabeth R. Bertone-Johnson

The globular tail domain puts on the brake to stop the ATPase cycle of myosin Va, Xiang-Dong Li, HyunSuk Jung, Qizhi Wang, Reiko Ikebe, Roger W. Craig, and Mitsuo Ikebe

Arthroscopic debridement of the osteoarthritic knee combined with hyaluronic acid (Orthovisc(R)) treatment: A case series and review of the literature, Xinning Li, Agam Shah, Patricia D. Franklin, Renee J. Merolli, Jill Bradley, and Brian D. Busconi

DnaC inactivation in Escherichia coli K-12 induces the SOS response and expression of nucleotide biosynthesis genes, Anders Lobner-Olesen, Monika Slominska-Wojewodzka, Flemming G. Hansen, and Martin G. Marinus

Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance, Shaolei Lu, Karl Simin, Ashraf Khan, and Arthur M. Mercurio

Nucleophosmin is a binding partner of nucleostemin in human osteosarcoma cells, Hanhui Ma and Thoru Pederson

Engineered intermonomeric disulfide bonds in the globular domain of Newcastle disease virus hemagglutinin-neuraminidase protein: implications for the mechanism of fusion promotion, Paul J. Mahon, Anne M. Mirza, Thomas A. Musich, and Ronald M. Iorio

Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice, Julie A. Mangada, Todd Pearson, Michael A. Brehm, Linda S. Wicker, Laurence B. Peterson, Leonard D. Shultz, David V. Serreze, Aldo A. Rossini, and Dale L. Greiner

Hypercholesterolemia impairs immunity to tuberculosis, Gregory W. Martens, Meltem Cevik Arikan, Jinhee Lee, Fucheng Ren, Therese Vallerskog, and Hardy Kornfeld

Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity, Natalia Julia Martinez, Maria C. Ow, John S. Reece-Hoyes, M. Inmaculada Barrasa, Victor R. Ambros, and Albertha J. M. Walhout

Interleukin-4 activates large-conductance, calcium-activated potassium (BKCa) channels in human airway smooth muscle cells, Gilles E. Martin, Robert J. O'Connell, Andrzej Z. Pietrzykowski, Steven N. Treistman, Michael F. Ethier, and John M. Madison

A chromatin assay for human brain tissue, Anouch Matevossian and Schahram Akbarian

Neuronal nuclei isolation from human postmortem brain tissue, Anouch Matevossian and Schahram Akbarian

Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus, Anuja Mathew, Joel O'Bryan, William L. Marshall, Girish J. Kotwal, Masanori Terajima, Sharone Green, Alan L. Rothman, and Francis A. Ennis

MdmX regulates transformation and chromosomal stability in p53-deficient cells, Zdenka Matijasevic, Anna Krzywicka-Racka, Greenfield Sluder, and Stephen N. Jones

Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study, Yunsheng Ma, James R. Hebert, Wenjun Li, Elizabeth R. Bertone-Johnson, Barbara C. Olendzki, Sherry L. Pagoto, Lesley F. Tinker, Milagros C. Rosal, Ira S. Ockene, Judith K. Ockene, Jennifer A. Griffith, and Simin Liu

Dietary quality 1 year after diagnosis of coronary heart disease, Yunsheng Ma, Wenjun Li, Barbara C. Olendzki, Sherry L. Pagoto, Philip A. Merriam, David E. Chiriboga, Jennifer A. Griffith, Jamie S. Bodenlos, Yanli Wang, and Ira S. Ockene

An Assessment of a Low-Cost Visual Tracking System (VTS) to Detect and Compensate for Patient Motion during SPECT, Joseph E. McNamara, Karen Johnson, Bing Feng, Songxiang Gu, Philippe P. Bruyant, Michael A. Gennert, and Michael A. King

P2Y12 antagonism: promises and challenges, Alan D. Michelson

Trp53 deletion stimulates the formation of metastatic pancreatic tumors, Jennifer P. Morton, David S. Klimstra, Michelle E. Mongeau, and Brian C. Lewis

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells, Rajini R. Mudhasani, Zhiqing Zhu, Gyorgy Hutvagner, Christine M. Eischen, Steven Lyle, Lisa L. Hall, Jeanne B. Lawrence, Anthony N. Imbalzano, and Stephen N. Jones