Founded in 2001, the Department of Neurobiology at the University of Massachusetts Medical School has evolved into a unique and integrated hub of investigators addressing fundamental problems in neurobiology, from single molecules to behavior, primarily using invertebrate model organisms. Combining cell biological, physiological and behavioral analyses with a critical interventionist angle afforded by cutting-edge genetic approaches, the Department aims to understand the complexity of brain development and function. This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurobiology.

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Publications from 2006

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Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain, Jian Wang, Ching-Hsien J. Lee, Suewei Lin, and Tzumin Lee

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Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons, Xiaoyan Zheng, Christopher T. Zugates, Zouyan Lu, Lei Shi, Jia-Min Bai, and Tzumin Lee

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Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity, Sijun Zhu, Suewei Lin, Chih-Fei Kao, Takeshi Awasaki, Ann-Shyn Chiang, and Tzumin Lee

Publications from 2005

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Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint, James A. Ashley, Mary Packard, Bulent Ataman, and Vivian Budnik

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Distinct structural features of phospholipids differentially determine ethanol sensitivity and basal function of BK channels, John J. Crowley, Steven N. Treistman, and Alejandro M. Dopico

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Glial (and neuronal) cells missing, Marc R. Freeman

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Glial control of synaptogenesis, Marc R. Freeman

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Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling, Antje Jilg, Juliane Moek, David R. Weaver, Horst-Werner Korf, Jorg H. Stehle, and Charlotte von Gall

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Drosophila memory: dopamine signals punishment, Alex Carl Keene and Scott Waddell

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Analysis of the prokineticin 2 system in a diurnal rodent, the unstriped Nile grass rat (Arvicanthis niloticus), Christopher M. Lambert, Kazuhiko K. Machida, Laura Smale, Antonio A. Nunez, and David R. Weaver

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Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2, Dennis Mathew, Bulent Ataman, Jinyun Chen, Yali Zhang, Susan Cumberledge, and Vivian Budnik

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Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics, Philip M. Newton, Keith Tully, Thomas McMahon, Jacklyn Connolly, Jahan Dadgar, Steven N. Treistman, and Robert O. Messing

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Connecting the navigational clock to sun compass input in monarch butterfly brain, Ivo Sauman, Adriana D. Briscoe, Haisun Zhu, Dingding Shi, Oren Froy, Julia Stalleicken, Quan Yuan, Amy L. Casselman, and Steven M. Reppert

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Melatonin plays a crucial role in the regulation of rhythmic clock gene expression in the mouse pars tuberalis, Charlotte von Gall, David R. Weaver, Juliane Moek, Antje Jilg, Jorg H. Stehle, and Horst-Werner Korf

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Courtship learning: scent of a woman, Scott Waddell

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Melatonin inhibits hippocampal long-term potentiation, Louisa M. Wang, Nanthia A. Suthana, Dipesh Chaudhury, David R. Weaver, and Christopher S. Colwell

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Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning, Dinghui Yu, Alex Carl Keene, Anjana Srivatsan, Scott Waddell, and Ronald L. Davis

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The two CRYs of the butterfly, Haisun Zhu, Quan Yuan, Adriana D. Briscoe, Oren Froy, Amy L. Casselman, and Steven M. Reppert

Publications from 2004

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Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception, Ania Busza, Myai Emery-Le, Michael Rosbash, and Patrick Emery

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A rhythmic Ror, Patrick Emery and Steven M. Reppert

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Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output, Alex Carl Keene, Markus Stratmann, Andreas Keller, Paola N. Perrat, Leslie B. Vosshall, and Scott Waddell

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Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock, Choogon Lee, David R. Weaver, and Steven M. Reppert

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Four-dimensional gene expression control: memories on the fly, Benjamin M. Leung and Scott Waddell

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Somatic localization of a specific large-conductance calcium-activated potassium channel subtype controls compartmentalized ethanol sensitivity in the nucleus accumbens, Gilles E. Martin, Sylvie I. Puig, Andrzej Z. Pietrzykowski, Paula L. Feinberg-Zadek, Patrick Emery, and Steven N. Treistman

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WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy, Tassula Proikas-Cezanne, Scott Waddell, Anja Gaugel, Tancred Frickey, Andrei Lupas, and Alfred Nordheim

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Polarized light helps monarch butterflies navigate, Steven M. Reppert, Haisun Zhu, and Richard H. White

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New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants, Catalina Ruiz-Canada, James A. Ashley, Stephanie Mockel-Cole, Eric Drier, Jerry Yin, and Vivian Budnik

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Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes, Priyattam J. Shiromani, Man Xu, Elizabeth M. Winston, Samara N. Shiromani, Dmitry Geraschenko, and David R. Weaver

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Distinct intracellular calcium profiles following influx through N- versus L-type calcium channels: role of Ca2+-induced Ca2+ release, Keith Tully and Steven N. Treistman

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Bilayer thickness modulates the conductance of the BK channel in model membranes, Chunbo Yuan, Robert J. O'Connell, Paula Leslie Feinberg-Zadek, Linda J. Johnston, and Steven N. Treistman

Publications from 2003

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Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyi, Dennis C. Chang, Harriet G. McWatters, Julie A. Williams, Anthony L. Gotter, Joel D. Levine, and Steven M. Reppert

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A novel C-terminal domain of drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcription, Dennis C. Chang and Steven M. Reppert

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Cholesterol antagonizes ethanol potentiation of human brain BKCa channels reconstituted into phospholipid bilayers, John J. Crowley, Steven N. Treistman, and Alejandro M. Dopico

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Rhythmic histone acetylation underlies transcription in the mammalian circadian clock, Jean-Pierre Etchegaray, Choogon Lee, Paul A. Wade, and Steven M. Reppert

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Development and validation of computational models for mammalian circadian oscillators, Daniel B. Forger, Dennis A. Dean II, Katherine Gurdziel, Jean-Christopher Leloup, Choogon Lee, Charlotte von Gall, Jean-Pierre Etchegaray, Richard E. Kronauer, Albert Goldbeter, Charles S. Peskin, Megan E. Jewett, and David R. Weaver

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Illuminating the circadian clock in monarch butterfly migration, Oren Froy, Anthony L. Gotter, Amy L. Casselman, and Steven M. Reppert

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Targeted disruption of the mouse Mel(1b) melatonin receptor, Xiaowei Jin, Charlotte von Gall, Rick L. Pieschl, Valentin K. Gribkoff, Jorg H. Stehle, Steven M. Reppert, and David R. Weaver

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Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling, Dennis Mathew, Andrei Popescue, and Vivian Budnik

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Expression and regulation of mPer1 in immortalized GnRH neurons, J. Olcese, R. Domagalski, A. Bednorz, David R. Weaver, H. F. Urbanski, S. Reuss, and R. Middendorff

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FASt remodeling of synapses in Drosophila, Mary Packard, Dennis Mathew, and Vivian Budnik

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Light does not degrade the constitutively expressed BMAL1 protein in the mouse suprachiasmatic nucleus, Charlotte von Gall, Elizabeth Noton, Choogon Lee, and David R. Weaver

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Protein phosphatase 1 and memory: practice makes PP1 imperfect, Scott Waddell

Publications from 2002

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Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus, Michelle Y. Cheng, Clayton M. Bullock, Chuanyu Li, Alex G. Lee, Jason C. Bermak, James Belluzzi, David R. Weaver, Frances M. Leslie, and Qun-Yong Zhou

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Coordination of circadian timing in mammals, Steven M. Reppert and David R. Weaver

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Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity, Zdenka Travnickova-Bendova, Nicolas Cermakian, Steven M. Reppert, and Paolo Sassone-Corsi

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Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin, Charlotte von Gall, Martine L. Garabette, Christian A. Kell, Sascha Frenzel, Faramarz Dehghani, Petra-Maria Schumm-Draeger, David R. Weaver, Horst-Werner Korf, Michael H. Hastings, and Jorg H. Stehle

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Mammalian melatonin receptors: molecular biology and signal transduction, Charlotte von Gall, Jorg H. Stehle, and David R. Weaver

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Forgetting those painful moments, Scott Waddell

Publications from 2001

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Distinct pharmacological mechanisms leading to c-fos gene expression in the fetal suprachiasmatic nucleus, L. P. Shearman and David R. Weaver