Founded in 2001, the Department of Neurobiology at the University of Massachusetts Medical School has evolved into a unique and integrated hub of investigators addressing fundamental problems in neurobiology, from single molecules to behavior, primarily using invertebrate model organisms. Combining cell biological, physiological and behavioral analyses with a critical interventionist angle afforded by cutting-edge genetic approaches, the Department aims to understand the complexity of brain development and function. This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurobiology.

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Publications from 2008

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Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam, Jacob S. Yang, Jia-Min Bai, and Tzumin Lee

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Rhythmic expression of clock genes in the ependymal cell layer of the third ventricle of rodents is independent of melatonin signaling, Shinobu Yasuo, Charlotte von Gall, David R. Weaver, and Horst-Werner Korf

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Chasing migration genes: a brain expressed sequence tag resource for summer and migratory monarch butterflies (Danaus plexippus), Haisun Zhu, Amy L. Casselman, and Steven M. Reppert

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Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation, Haisun Zhu, Ivo Sauman, Quan Yuan, Amy L. Casselman, Myai Emery-Le, Patrick Emery, and Steven M. Reppert

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Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling, Jennifer S. Ziegenfuss, Romi Biswas, Michelle A. Avery, Kyoungja Hong, Amy E. Sheehan, Yee-Guide Yeung, E. Richard Stanley, and Marc R. Freeman

Publications from 2007

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Transient, light-induced rhythmicity in mPer-deficient mice, Kiho Bae and David R. Weaver

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The evolution of N-glycan-dependent endoplasmic reticulum quality control factors for glycoprotein folding and degradation, Sulagna Banerjee, Prashanth Vishwanath, Jike Cui, Daniel J. Kelleher, Reid Gilmore, Phillips W. Robbins, and John Samuelson

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Interactions between circadian neurons control temperature synchronization of Drosophila behavior, Ania Busza, Alejandro D. Murad, and Patrick Emery

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CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock, Jason P. DeBruyne, David R. Weaver, and Steven M. Reppert

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Peripheral circadian oscillators require CLOCK, Jason P. DeBruyne, David R. Weaver, and Steven M. Reppert

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Mutagenesis with Drosophila, Patrick Emery

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Protein extraction from Drosophila heads, Patrick Emery

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RNA extraction from Drosophila heads, Patrick Emery

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RNase protection assay, Patrick Emery

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Glia got rhythm, Patrick Emery and Marc R. Freeman

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A look inside, Marc R. Freeman

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A potential dimerization region of dCAMTA is critical for termination of fly visual response, Ping Gong, Junhai Han, Keith Reddig, and Hong-Sheng Li

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Postsynaptic membrane addition depends on the Discs-Large-interacting t-SNARE Gtaxin, David Gorczyca, James A. Ashley, Sean Speese, Norberto G. Gherbesi, Ulrich Thomas, Eckart Gundelfinger, L. Sian Gramates, and Vivian Budnik

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Prolonged G(q) activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity, Junhai Han, Keith Reddig, and Hong-Sheng Li

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PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila, Rachna Kaushik, Pipat Nawathean, Ania Busza, Alejandro D. Murad, Patrick Emery, and Michael Rosbash

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Drosophila olfactory memory: single genes to complex neural circuits, Alex Carl Keene and Scott Waddell

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Sequential use of mushroom body neuron subsets during drosophila odor memory processing, Michael Jonathan Krashes, Alex Carl Keene, Benjamin M. Leung, J. Douglas Armstrong, and Scott Waddell

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Identification of novel regulatory factor X (RFX) target genes by comparative genomics in Drosophila species, Anne Laurencon, Raphaelle Dubruille, Evgeni Efimenko, Guillaume Grenier, Ryan Bissett, Elisabeth Cortier, Vivien Rolland, Peter Swoboda, and Benedicte Durand

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Smelling excitement in the antennal lobe, Benjamin M. Leung and Scott Waddell

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Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission, Jingjun Li, James A. Ashley, Vivian Budnik, and Manzoor A. Bhat

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The scoop on the fly brain: glial engulfment functions in Drosophila, Mary A. Logan and Marc R. Freeman

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A subset of dorsal neurons modulates circadian behavior and light responses in Drosophila, Alejandro D. Murad, Myai Emery-Le, and Patrick Emery

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The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo, Jamie L. Rickmyre, Shamik DasGupta, Danny Liang-Yee Ooi, Jessica Keel, Ethan Lee, Marc W. Kirschner, Scott Waddell, and Laura A. Lee

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Roles of Drosophila Kruppel-homolog 1 in neuronal morphogenesis, Lei Shi, Suewei Lin, Yelena Grinberg, Yannick Beck, Christina M. Grozinger, Gene E. Robinson, and Tzumin Lee

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Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization, Lei Shi, Hung-Hsiang Yu, Jacob S. Yang, and Tzumin Lee

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Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization, Peter Soba, Sijun Zhu, Kazuo Emoto, Susan Younger, Shun-Jen Yang, Hung-Hsiang Yu, Tzumin Lee, Lily Yeh Jan, and Yuh-Nung Jan

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Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization, Peter Soba, Sijun Zhu, Kazuo Emoto, Susan Younger, Shun-Jen Yang, Hung-Hsiang Yu, Tzumin Lee, Lily Yeh Jan, and Yuh-Nung Jan

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Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly, Sang-Hun Song, Nuri Ozturk, Tracy R. Denaro, N. Ozlem Arat, Ya-Ting Kao, Haisun Zhu, Dongping Zhong, Steven M. Reppert, and Aziz Sancar

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Wnts: up-and-coming at the synapse, Sean D. Speese and Vivian Budnik

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Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks, Quan Yuan, Danielle Metterville, Adriana D. Briscoe, and Steven M. Reppert

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Neuronal temporal identity in post-embryonic Drosophila brain, Hung-Hsiang Yu and Tzumin Lee

Publications from 2006

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Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP, Bulent Ataman, James A. Ashley, David Gorczyca, Michael Gorczyca, Dennis Mathew, Carolin Wichmann, Stephan J. Sigrist, and Vivian Budnik

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Scaffolding proteins at the Drosophila neuromuscular junction, Bulent Ataman, Vivian Budnik, and Ulrich Thomas

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Selected methods for the anatomical study of Drosophila embryonic and larval neuromuscular junctions, Vivian Budnik, Michael Gorczyca, and Andreas Prokop

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The Fly Neuromuscular Junction: Structure and Function, Vivian Budnik and Catalina Ruiz-Canada

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A clock shock: mouse CLOCK is not required for circadian oscillator function, Jason P. DeBruyne, Elizabeth Noton, Christopher M. Lambert, Elizabeth S. Maywood, David R. Weaver, and Steven M. Reppert

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The polycomb group protein EZH2 is required for mammalian circadian clock function, Jean-Pierre Etchegaray, Xiaoming Yang, Jason P. DeBruyne, Antoine H.F.M. Peters, David R. Weaver, Thomas Jenuwein, and Steven M. Reppert

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The Drosophila radish gene encodes a protein required for anesthesia-resistant memory, Elisabeth Folkers, Scott Waddell, and William G. Quinn

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Sculpting the nervous system: glial control of neuronal development, Marc R. Freeman

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Glial cell biology in Drosophila and vertebrates, Marc R. Freeman and Johnna E. Doherty

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Plasticity and second messengers during synapse development, Leslie C. Griffith and Vivian Budnik

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The fly CAMTA transcription factor potentiates deactivation of rhodopsin, a G protein-coupled light receptor, Junhai Han, Ping Gong, Keith Reddig, Mirna Mitra, Peiyi Guo, and Hong-Sheng Li

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Drosophila dorsal paired medial neurons provide a general mechanism for memory consolidation, Alex Carl Keene, Michael Jonathan Krashes, Benjamin M. Leung, Jessica A. Bernard, and Scott Waddell

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Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia, Ya-Huei Kuo, Sean F. Landrette, Susan Ann Heilman, Paola N. Perrat, Lisa Garrett, Pu P. Liu, Michelle M. Le Beau, Scott C. Kogan, and Lucio H. Castilla

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Genetic mosaic with dual binary transcriptional systems in Drosophila, Sen-Lin Lai and Tzumin Lee

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Peripheral gene expression rhythms in a diurnal rodent, Christopher M. Lambert and David R. Weaver

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The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons, Jennifer MacDonald, Margaret Beach, Ermelinda Porpiglia, Amy E. Sheehan, Ryan J. Watts, and Marc R. Freeman

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A colorful model of the circadian clock, Steven M. Reppert

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Introduction on the use of the Drosophila embryonic/larval neuromuscular junction as a model system to study synapse development and function, and a brief summary of pathfinding and target recognition, Catalina Ruiz-Canada and Vivian Budnik

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Synaptic cytoskeleton at the neuromuscular junction, Catalina Ruiz-Canada and Vivian Budnik

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Ectopic CRYPTOCHROME renders TIM light sensitive in the Drosophila ovary, Brandy L. Rush, Alejandro D. Murad, Patrick Emery, and Jadwiga M. Giebultowicz

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Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain, Jian Wang, Ching-Hsien J. Lee, Suewei Lin, and Tzumin Lee

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Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons, Xiaoyan Zheng, Christopher T. Zugates, Zouyan Lu, Lei Shi, Jia-Min Bai, and Tzumin Lee

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Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity, Sijun Zhu, Suewei Lin, Chih-Fei Kao, Takeshi Awasaki, Ann-Shyn Chiang, and Tzumin Lee

Publications from 2005

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Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint, James A. Ashley, Mary Packard, Bulent Ataman, and Vivian Budnik

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Distinct structural features of phospholipids differentially determine ethanol sensitivity and basal function of BK channels, John J. Crowley, Steven N. Treistman, and Alejandro M. Dopico

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Glial (and neuronal) cells missing, Marc R. Freeman

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Glial control of synaptogenesis, Marc R. Freeman

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Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling, Antje Jilg, Juliane Moek, David R. Weaver, Horst-Werner Korf, Jorg H. Stehle, and Charlotte von Gall

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Mapping the interaction of the STT3 subunit of the oligosaccharyl transferase complex with nascent polypeptide chains, Andrey L. Karamyshev, Daniel J. Kelleher, Reid Gilmore, Arthur E. Johnson, Gunnar von Heijne, and Ingmarie Nilsson

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Drosophila memory: dopamine signals punishment, Alex Carl Keene and Scott Waddell

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Drosophila memory: dopamine signals punishment, Alex Carl Keene and Scott Waddell

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Analysis of the prokineticin 2 system in a diurnal rodent, the unstriped Nile grass rat (Arvicanthis niloticus), Christopher M. Lambert, Kazuhiko K. Machida, Laura Smale, Antonio A. Nunez, and David R. Weaver

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Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2, Dennis Mathew, Bulent Ataman, Jinyun Chen, Yali Zhang, Susan Cumberledge, and Vivian Budnik

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Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics, Philip M. Newton, Keith Tully, Thomas McMahon, Jacklyn Connolly, Jahan Dadgar, Steven N. Treistman, and Robert O. Messing

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The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases, John Samuelson, Sulagna Banerjee, Paula Magnelli, Jike Cui, Daniel J. Kelleher, Reid Gilmore, and Phillips W. Robbins

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Connecting the navigational clock to sun compass input in monarch butterfly brain, Ivo Sauman, Adriana D. Briscoe, Haisun Zhu, Dingding Shi, Oren Froy, Julia Stalleicken, Quan Yuan, Amy L. Casselman, and Steven M. Reppert

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Melatonin plays a crucial role in the regulation of rhythmic clock gene expression in the mouse pars tuberalis, Charlotte von Gall, David R. Weaver, Juliane Moek, Antje Jilg, Jorg H. Stehle, and Horst-Werner Korf

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Courtship learning: scent of a woman, Scott Waddell

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Melatonin inhibits hippocampal long-term potentiation, Louisa M. Wang, Nanthia A. Suthana, Dipesh Chaudhury, David R. Weaver, and Christopher S. Colwell

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Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning, Dinghui Yu, Alex Carl Keene, Anjana Srivatsan, Scott Waddell, and Ronald L. Davis

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The two CRYs of the butterfly, Haisun Zhu, Quan Yuan, Adriana D. Briscoe, Oren Froy, Amy L. Casselman, and Steven M. Reppert

Publications from 2004

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Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception, Ania Busza, Myai Emery-Le, Michael Rosbash, and Patrick Emery

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Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia, Lucio H. Castilla, Paola N. Perrat, Natalia Julia Martinez, Sean F. Landrette, R. Keys, Sarah R. Oikemus, J. Flanegan, Susan Ann Heilman, Lisa Garrett, A. Dutra, S. Anderson, German A. Pihan, L. Wolff, and Pu P. Liu

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A rhythmic Ror, Patrick Emery and Steven M. Reppert

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Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output, Alex Carl Keene, Markus Stratmann, Andreas Keller, Paola N. Perrat, Leslie B. Vosshall, and Scott Waddell

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Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11, Sean F. Landrette, Ya-Huei Kuo, Karen Hensen, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Paola N. Perrat, Wim J. M. Van de Ven, Ruud Delwel, and Lucio H. Castilla

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Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock, Choogon Lee, David R. Weaver, and Steven M. Reppert

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Four-dimensional gene expression control: memories on the fly, Benjamin M. Leung and Scott Waddell

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Somatic localization of a specific large-conductance calcium-activated potassium channel subtype controls compartmentalized ethanol sensitivity in the nucleus accumbens, Gilles E. Martin, Sylvie I. Puig, Andrzej Z. Pietrzykowski, Paula L. Feinberg-Zadek, Patrick Emery, and Steven N. Treistman

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Alcohol tolerance in large-conductance, calcium-activated potassium channels of CNS terminals is intrinsic and includes two components: decreased ethanol potentiation and decreased channel density, Andrzej Z. Pietrzykowski, Gilles E. Martin, Sylvie I. Puig, Thomas K. Knott, Jose R. Lemos, and Steven N. Treistman

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WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy, Tassula Proikas-Cezanne, Scott Waddell, Anja Gaugel, Tancred Frickey, Andrei Lupas, and Alfred Nordheim

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Polarized light helps monarch butterflies navigate, Steven M. Reppert, Haisun Zhu, and Richard H. White

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New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants, Catalina Ruiz-Canada, James A. Ashley, Stephanie Mockel-Cole, Eric Drier, Jerry Yin, and Vivian Budnik

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Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes, Priyattam J. Shiromani, Man Xu, Elizabeth M. Winston, Samara N. Shiromani, Dmitry Geraschenko, and David R. Weaver

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Distinct intracellular calcium profiles following influx through N- versus L-type calcium channels: role of Ca2+-induced Ca2+ release, Keith Tully and Steven N. Treistman

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Bilayer thickness modulates the conductance of the BK channel in model membranes, Chunbo Yuan, Robert J. O'Connell, Paula Leslie Feinberg-Zadek, Linda J. Johnston, and Steven N. Treistman

Publications from 2003

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Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyi, Dennis C. Chang, Harriet G. McWatters, Julie A. Williams, Anthony L. Gotter, Joel D. Levine, and Steven M. Reppert

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A novel C-terminal domain of drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcription, Dennis C. Chang and Steven M. Reppert

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Cholesterol and Phospholipid Modulation of BK[subscript Ca] Channel Activity and Ethanol Sensitivity: a dissertation, John J. Crowley

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Cholesterol antagonizes ethanol potentiation of human brain BKCa channels reconstituted into phospholipid bilayers, John J. Crowley, Steven N. Treistman, and Alejandro M. Dopico

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Cholesterol antagonizes ethanol potentiation of human brain BKCa channels reconstituted into phospholipid bilayers, John J. Crowley, Steven N. Treistman, and Alejandro M. Dopico

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Rhythmic histone acetylation underlies transcription in the mammalian circadian clock, Jean-Pierre Etchegaray, Choogon Lee, Paul A. Wade, and Steven M. Reppert

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Development and validation of computational models for mammalian circadian oscillators, Daniel B. Forger, Dennis A. Dean II, Katherine Gurdziel, Jean-Christopher Leloup, Choogon Lee, Charlotte von Gall, Jean-Pierre Etchegaray, Richard E. Kronauer, Albert Goldbeter, Charles S. Peskin, Megan E. Jewett, and David R. Weaver

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Illuminating the circadian clock in monarch butterfly migration, Oren Froy, Anthony L. Gotter, Amy L. Casselman, and Steven M. Reppert