Protein phosphatase 1 and memory: practice makes PP1 imperfect
Department of Neurobiology
Medical Subject Headings
Animals; *Learning; *Memory; Mice; Mice, Transgenic; Phosphoprotein Phosphatases; Prosencephalon; Protein Phosphatase 1; *Signal Transduction
Neuroscience and Neurobiology
Long-lasting memories are most efficiently formed by multiple training sessions separated by appropriately timed intervals. A recent study revealed that expression of a transgene encoding an inhibitor of protein phosphatase 1 (PP1) in the forebrain enhanced memory formed during sub-optimal training. Thus, PP1 apparently constrains memory formation in the mouse. Furthermore, the report proposes that PP1 promotes forgetting.
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Citation: Trends Neurosci. 2003 Mar;26(3):117-9.