Title

FASt remodeling of synapses in Drosophila

UMMS Affiliation

Department of Neurobiology

Date

10-2003

Document Type

Article

Medical Subject Headings

Animals; Cell Adhesion Molecules, Neuronal; Drosophila; Drosophila Proteins; Humans; Immunoglobulins; Synapses

Disciplines

Neuroscience and Neurobiology

Abstract

Cell adhesion molecules of the immunoglobulin superfamily (IgCAMS) play pivotal roles during synapse development and remodeling, being required in both activity-dependent and activity independent aspects of these processes. Recent advances using the fruit fly neuromuscular junction, as well as the mollusk Aplysia californica, have provided evidence for at least three mechanisms by which levels of IgCAMs are regulated during synapse remodeling--activity-dependent regulation of IgCAM clustering by PSD-95-type molecules, IgCAM internalization by MAP kinase pathway activation, and postsynaptic IgCAM exocytosis. These studies offer convincing evidence that synaptic cell adhesion brings about both negative and positive forces that stabilize synapses, while maintaining their ability to change in an activity-dependent manner.

Rights and Permissions

Citation: Curr Opin Neurobiol. 2003 Oct;13(5):527-34.

Related Resources

Link to Article in PubMed