Title

A rhythmic Ror

UMMS Affiliation

Department of Neurobiology; Emery Lab; Reppert Lab

Date

8-19-2004

Document Type

Article

Medical Subject Headings

ARNTL Transcription Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Humans; Nuclear Receptor Subfamily 1, Group F, Member 1; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Trans-Activators; Transcription Factors

Disciplines

Neuroscience and Neurobiology

Abstract

The circadian clock mechanism in mammals involves two interlocking transcriptional feedback loops. Rev-erb alpha, through its role as a transcriptional repressor, was thought to be the primary determinant of the feedback loop that regulates Bmal1 transcription. Results reported by Sato et al. in this issue of Neuron now show that the transactivator Rora acts coordinately with Rev-erb alpha and that their competing activities on the same promoter element drive the rhythm in Bmal1 transcription. This finding defines the second feedback loop in mammals.

Rights and Permissions

Citation: Neuron. 2004 Aug 19;43(4):443-6. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

15312644