A rhythmic Ror
Department of Neurobiology
Medical Subject Headings
ARNTL Transcription Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Humans; Nuclear Receptor Subfamily 1, Group F, Member 1; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Trans-Activators; Transcription Factors
Neuroscience and Neurobiology
The circadian clock mechanism in mammals involves two interlocking transcriptional feedback loops. Rev-erb alpha, through its role as a transcriptional repressor, was thought to be the primary determinant of the feedback loop that regulates Bmal1 transcription. Results reported by Sato et al. in this issue of Neuron now show that the transactivator Rora acts coordinately with Rev-erb alpha and that their competing activities on the same promoter element drive the rhythm in Bmal1 transcription. This finding defines the second feedback loop in mammals.
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Citation: Neuron. 2004 Aug 19;43(4):443-6. Link to article on publisher's site