The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon
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Document Type
Journal ArticlePublication Date
2009-12-01Keywords
Activin ReceptorsActivin Receptors, Type II
Activins
Amino Acid Sequence
Animals
Body Patterning
Carrier Proteins
Drosophila Proteins
Drosophila melanogaster
Gene Expression Regulation, Developmental
Ligands
Molecular Sequence Data
Protein Isoforms
Receptors, Cell Surface
*Signal Transduction
Wing
Neuroscience and Neurobiology
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Show full item recordAbstract
How TGF-beta-type ligands achieve signaling specificity during development is only partially understood. Here, we show that Dawdle, one of four Activin-type ligands in Drosophila, preferentially signals through Babo(c), one of three isoforms of the Activin Type-I receptor that are expressed during development. In cell culture, Dawdle signaling is active in the presence of the Type-II receptor Punt but not Wit, demonstrating that the Type-II receptor also contributes to the specificity of the signaling complex. During development, different larval tissues express unique combinations of these receptors, and ectopic expression of Babo(c) in a tissue where it is not normally expressed at high levels can make that tissue sensitive to Dawdle signaling. These results reveal a mechanism by which distinct cell types can discriminate between different Activin-type signals during development as a result of differential expression of Type-I receptor isoforms.Source
Mech Dev. 2009 Dec;126(11-12):950-7. Epub 2009 Sep 18. Link to article on publisher's siteDOI
10.1016/j.mod.2009.09.003Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37957PubMed ID
19766717Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.mod.2009.09.003