The molecular ticks of the Drosophila circadian clock
Department of Neurobiology; Emery Lab
Neuroscience and Neurobiology
Drosophila is a powerful model to understand the mechanisms underlying circadian rhythms. The Drosophila molecular clock is comprised of transcriptional feedback loops. The expressions of the critical transcriptional activator CLK and its repressors PER and TIM are under tight transcriptional control. However, posttranslational modification of these proteins and regulation of their stability are critical to their function and to the generation of 24-hr period rhythms. We review here recent progress made in our understanding of PER, TIM and CLK posttranslational control. We also review recent studies that are uncovering the importance of novel regulatory mechanisms that affect mRNA stability and translation of circadian pacemaker proteins and their output.
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Citation: Curr Opin Insect Sci. 2015 Feb 1;7:51-57. Link to article on publisher's site
Tataroglu, Ozgur and Emery, Patrick, "The molecular ticks of the Drosophila circadian clock" (2015). Neurobiology Publications and Presentations. 164.