Title

The molecular ticks of the Drosophila circadian clock

UMMS Affiliation

Department of Neurobiology; Emery Lab

Date

2-1-2015

Document Type

Article

Disciplines

Neuroscience and Neurobiology

Abstract

Drosophila is a powerful model to understand the mechanisms underlying circadian rhythms. The Drosophila molecular clock is comprised of transcriptional feedback loops. The expressions of the critical transcriptional activator CLK and its repressors PER and TIM are under tight transcriptional control. However, posttranslational modification of these proteins and regulation of their stability are critical to their function and to the generation of 24-hr period rhythms. We review here recent progress made in our understanding of PER, TIM and CLK posttranslational control. We also review recent studies that are uncovering the importance of novel regulatory mechanisms that affect mRNA stability and translation of circadian pacemaker proteins and their output.

Rights and Permissions

Citation: Curr Opin Insect Sci. 2015 Feb 1;7:51-57. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

26120561