Microglia Function in Central Nervous System Development and Plasticity
Document Type
Journal ArticlePublication Date
2015-07-17Keywords
Neuroscience and Neurobiology
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Show full item recordAbstract
The nervous system comprises a remarkably diverse and complex network of different cell types, which must communicate with one another with speed, reliability, and precision. Thus, the developmental patterning and maintenance of these cell populations and their connections with one another pose a rather formidable task. Emerging data implicate microglia, the resident myeloid-derived cells of the central nervous system (CNS), in the spatial patterning and synaptic wiring throughout the healthy, developing, and adult CNS. Importantly, new tools to specifically manipulate microglia function have revealed that these cellular functions translate, on a systems level, to effects on overall behavior. In this review, we give a historical perspective of work to identify microglia function in the healthy CNS and highlight exciting new work in the field that has identified roles for these cells in CNS development, maintenance, and plasticity.Source
Cold Spring Harb Perspect Biol. 2015 Jul 17;7(10):a020545. doi: 10.1101/cshperspect.a020545. Link to article on publisher's siteDOI
10.1101/cshperspect.a020545Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37893PubMed ID
26187728Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1101/cshperspect.a020545