Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages
Department of Neurobiology; Schafer Lab
Immunity | Neuroscience and Neurobiology
Mutations in methyl-CpG-binding protein 2 (MECP2) underlie most cases of Rett Syndrome, a neurodevelopmental disorder with neurological and somatic impairments. In this issue of Immunity, Cronk et al. (2015) find that macrophages in MeCP2-deficient mice are abnormal in number, as well as in glucocorticoid, hypoxia, and inflammatory responses.
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Citation: Immunity. 2015 Apr 21;42(4):600-2. doi: 10.1016/j.immuni.2015.04.002. Link to article on publisher's site
Schafer, Dorothy P. and Stevens, Beth, "Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages" (2015). Neurobiology Publications and Presentations. 162.