Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Student Authors
Jeffrey FrostUMass Chan Affiliations
Graduate School of Biomedical Sciences, Neuroscience ProgramSchafer Lab
Neurobiology
Document Type
Journal ArticlePublication Date
2016-08-01Keywords
central nervous systemdevelopment
microglia
Cell Biology
Developmental Biology
Developmental Neuroscience
Metadata
Show full item recordAbstract
Microglia are resident macrophages of the central nervous system (CNS), representing 5-10% of total CNS cells. Recent findings reveal that microglia enter the embryonic brain, take up residence before the differentiation of other CNS cell types, and become critical regulators of CNS development. Here, we discuss exciting new work implicating microglia in a range of developmental processes, including regulation of cell number and spatial patterning of CNS cells, myelination, and formation and refinement of neural circuits. Furthermore, we review studies suggesting that these cellular functions result in the modulation of behavior, which has important implications for a variety of neurological disorders.Source
Trends Cell Biol. 2016 Aug;26(8):587-97. doi: 10.1016/j.tcb.2016.02.006. Epub 2016 Mar 20. Link to article on publisher's siteDOI
10.1016/j.tcb.2016.02.006Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37885PubMed ID
27004698Notes
First author Jeffrey Frost is a doctoral student in the Neuroscience Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.
Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.tcb.2016.02.006