Glia instruct developmental neuronal remodeling through TGF-beta signaling
Department of Neurobiology
Medical Subject Headings
Animals; Animals, Genetically Modified; Drosophila; Drosophila Proteins; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; MicroRNAs; *Models, Neurological; Mushroom Bodies; Mutation; Neurogenesis; Neuroglia; RNA, Double-Stranded; Signal Transduction; Transforming Growth Factor beta
Neuroscience and Neurobiology
We found that glia secrete myoglianin, a TGF-beta ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.
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Citation: Nat Neurosci. 2011 Jun 19;14(7):821-3. doi: 10.1038/nn.2833. Link to article on publisher's site