Hierarchical deployment of factors regulating temporal fate in a diverse neuronal lineage of the Drosophila central brain
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Document Type
Journal ArticlePublication Date
2012-02-23Keywords
AnimalsAnimals, Genetically Modified
Body Patterning
Brain
Cell Lineage
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Gene Expression Regulation, Developmental
Homeodomain Proteins
Kruppel-Like Transcription Factors
Mutation
Nerve Tissue Proteins
Neurons
POU Domain Factors
Signal Transduction
Transcription Factors
Neuroscience and Neurobiology
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Show full item recordAbstract
The anterodorsal projection neuron lineage of Drosophila melanogaster produces 40 neuronal types in a stereotypic order. Here we take advantage of this complete lineage sequence to examine the role of known temporal fating factors, including Chinmo and the Hb/Kr/Pdm/Cas transcriptional cascade, within this diverse central brain lineage. Kr mutation affects the temporal fate of the neuroblast (NB) itself, causing a single fate to be skipped, whereas Chinmo null only elicits fate transformation of NB progeny without altering cell counts. Notably, Chinmo operates in two separate windows to prevent fate transformation (into the subsequent Chinmo-indenpendent fate) within each window. By contrast, Hb/Pdm/Cas play no detectable role, indicating that Kr either acts outside of the cascade identified in the ventral nerve cord or that redundancy exists at the level of fating factors. Therefore, hierarchical fating mechanisms operate within the lineage to generate neuronal diversity in an unprecedented fashion.Source
Neuron. 2012 Feb 23;73(4):677-84. Link to article on publisher's siteDOI
10.1016/j.neuron.2011.12.018Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37859PubMed ID
22365543Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.neuron.2011.12.018