Dopamine reveals neural circuit mechanisms of fly memory

UMMS Affiliation

Department of Neurobiology; Waddell Lab



Document Type


Medical Subject Headings

Animals; Appetitive Behavior; Avoidance Learning; Dopamine; Drosophila; Memory; Mushroom Bodies; Nerve Net; Neural Pathways; Neurons; Reinforcement (Psychology); Synapses


Neuroscience and Neurobiology


A goal of memory research is to understand how changing the weight of specific synapses in neural circuits in the brain leads to an appropriate learned behavioral response. Finding the relevant synapses should allow investigators to probe the underlying physiological and molecular operations that encode memories and permit their retrieval. In this review I discuss recent work in Drosophila that implicates specific subsets of dopaminergic (DA) neurons in aversive reinforcement and appetitive motivation. The zonal architecture of these DA neurons is likely to reveal the functional organization of aversive and appetitive memory in the mushroom bodies. Combinations of fly DA neurons might code negative and positive value, consistent with a motivational systems role as proposed in mammals.


Citation: Trends Neurosci. 2010 Oct;33(10):457-64. Epub 2010 Aug 10. Link to article on publisher's site

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