This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurology.

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Publications from 1999

Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-1999. A 67-year-old man with three years of dementia, David A. Drachman and Kathy L. Newell

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Antithrombotic and thrombolytic therapy for ischemic stroke, Marc Fisher

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Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke, Marc Fisher and Gregory W. Albers

Current Review of Cerebrovascular Disease (3rd ed.), Marc Fisher and Julien Bogousslavsky

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Pharmacological approaches to stroke recovery, Marc Fisher and Seth P. Finklestein

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Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats, Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, Christopher H. Sotak, and Marc Fisher

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Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats, Fuhai Li, Tsuyoshi Omae, and Marc Fisher

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On the neural correlates of visual perception, Daniel A. Pollen

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Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia, Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, Kenneth W. Locke, and Marc Fisher

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Myocardial infarction, seizure and an abnormal head CT scan, Nithianandam Selvaraj, David A. Drachman, Paula D. Ravin, and John R. Knorr

Publications from 1998

From capitation to rhinocitation, Jeffrey D. Bernhard and David A. Drachman

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A first-year minicurriculum on TIA/stroke, Susan Billings-Gagliardi, Nancy M. Fontneau, and Michele P. Pugnaire

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Determination of focal ischemic lesion volume in the rat brain using multispectral analysis, Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, Marc Fisher, and Christopher H. Sotak

Degenerative Dementias, David A. Drachman and Joan M. Swearer

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The travails of neuroprotective drug development for acute ischemic stroke, Marc Fisher

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Further evolution toward effective therapy for acute ischemic stroke, Marc Fisher and Julien Bogousslavsky

Textbook of Neurology, Marc Fisher and Julien Bogousslavsky

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A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging, Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, Christopher H. Sotak, and Marc Fisher

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Amastigote surface proteins of Trypanosoma cruzi are targets for CD8+ CTL, Hoi Pang Low, Maria A. M. Santos, Benjamin Wizel, and Rick L. Tarleton

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Phase resetting of the respiratory oscillator by carotid sinus nerve stimulation in cats, David Paydarfar, Frederic L. Eldridge, and Joseph A. Paydarfar

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Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging, Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, H. D. Kleinert, and Marc Fisher

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A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study, Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, Christopher H. Sotak, and Marc Fisher

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Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion, Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, Alan C. Foster, and Marc Fisher

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A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion, Turgut Tatlisumak, Kentaro Takano, Michael R. Meiler, and Marc Fisher

Publications from 1997

Aging and the brain: a new frontier, David A. Drachman

Treatment of Alzheimer's disease -- searching for a breakthrough, settling for less, David A. Drachman and Paul Leber

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Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat, Giora Z. Feuerstein, Marc Fisher, John J. Nunnari, and Robert R. Ruffolo Jr.

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Characterizing the target of acute stroke therapy, Marc Fisher

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Embryonic precursor cells that express Trk receptors: induction of different cell fates by NGF, BDNF, NT-3, and CNTF, Mahesh B. Lachyankar, Peter J. Condon, Peter J. Quesenberry, N. Scott Litofsky, Lawrence D. Recht, and Alonzo H. Ross

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TrkA expression decreases the in vivo aggressiveness of C6 glioma cells, Mahesh B. Lachyankar, Alonzo H. Ross, N. Scott Litofsky, Peter J. Condon, Peter J. Quesenberry, and Lawrence D. Recht

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Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model, Fuhai Li, Katsumi Irie, M. Sawkat Anwer, and Marc Fisher

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Molecular cloning of the gene encoding the 83 kDa amastigote surface protein and its identification as a member of the Trypanosoma cruzi sialidase superfamily, Hoi Pang Low and Rick L. Tarleton

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Dde-I restriction endonuclease fragmentation: a novel method of generating cDNA probes for in situ hybridization in brain, Richard H. Melloni, Neil Aronin, Louis J. DeGennaro, Craig F. Ferris, and Robert J. Harrison

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Acute ischemic stroke therapy. A clinical overview, M. Zulkuf Onal and Marc Fisher

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Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats, M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, Bobby W. Sandage Jr., and Marc Fisher

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Caretaker Obstreperous Behavior Rating Scale, Joan M. Swearer and David A. Drachman

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Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats, Kentaro Takano, Turgut Tatlisumak, Andreas G. Bergmann, Daniel G. Gibson III, and Marc Fisher

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Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies, Kentaro Takano, Turgut Tatlisumak, James E. Formato, Richard A.D. Carano, Andreas G. Bergmann, Linda M. Pullan, Thomas M. Bare, Christopher H. Sotak, and Marc Fisher

Publications from 1996

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Acute and atypical presentations of syringomyelia, Ursula E. Anwer and Marc Fisher

Screening for dementia: Cognitive Assessment Screening Test (CAST), David A. Drachman and Joan M. Swearer

The cognitive assessment screening test (CAST) for dementia, David A. Drachman, Joan M. Swearer, Kevin J. Kane, Diane L. Osgood, Colleen O'Toole, and Majaz Moonis

Current Review of Cerebrovascular Disease (2nd ed.), Marc Fisher and Julien Bogousslavsky

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Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water, Yasuhiro Hasegawa, James E. Formato, Lawrence L. Latour, Jorge A. Gutierrez, Kai-Feng Liu, Julio H. Garcia, Christopher H. Sotak, and Marc Fisher

Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway, Carol F. Lippa, Ann M. Saunders, Thomas W. Smith, Joan M. Swearer, David A. Drachman, Bernardino Ghetti, Linda Nee, D. Pulaski-Salo, Dennis Dickson, Yves Robitaille, C. Bergeron, Barbara Crain, Merrill D. Benson, Martin R. Farlow, Bradley T. Hyman, Peter H. St. George-Hyslop, Allen D. Roses, and Daniel A. Pollen

Foreign Accent Syndrome Following a Closed Head Injury: Perfusion Deficit on Single Photon Emission Tomography with Normal Magnetic Resonance Imaging, Majaz Moonis, Joan M. Swearer, S. E. Blumstein, K. Kurowski, Robert Licho, P. Kramer, Ann L. Mitchell, Diane L. Osgood, and David A. Drachman

Medical therapy for ischemic stroke, Brian Silver, Johannes Weber, and Marc Fisher

Predicting Aberrant Behavior in Alzheimer's Disease, Joan M. Swearer, Nancy E. Hoople, Kevin J. Kane, and David A. Drachman

Rate of progression in familial Alzheimer's disease, Joan M. Swearer, Brian F. O'Donnell, Susan M. Ingram, and David A. Drachman

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The role of spreading depression in focal ischemia evaluated by diffusion mapping, Kentaro Takano, Lawrence L. Latour, James E. Formato, Richard A.D. Carano, Karl G. Helmer, Yasuhiro Hasegawa, Christopher H. Sotak, and Marc Fisher

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Hematologic disorders associated with ischemic stroke, Turgut Tatlisumak and Marc Fisher

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Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging, Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, and Marc Fisher

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Middle fossa cyst presenting as a delayed complication of temporal lobectomy: case report, John P. Weaver, Catherine Phillips, Sandra L. Horowitz, and Sheldon Benjamin

Publications from 1995

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Acute stroke treatment trials in the United States. Rethinking strategies for success, Robert J. Adams, Marc Fisher, Anthony J. Furlan, and Gregory del Zoppo

Diagnosis and evaluation of dementia, Jody Corey-Bloom, Leon J. Thal, Douglas R. Galasko, Marshall F. Folstein, David A. Drachman, Murray A. Raskind, and Douglas J. Lanska

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Diffusion and perfusion imaging for acute stroke, Marc Fisher

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Potentially effective therapies for acute ischemic stroke, Marc Fisher

Stroke Therapy, Marc Fisher

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Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats, Marc Fisher, Mary-Ellen Meadows, Tuyen Do, Jens Weise, Vladimir Trubetskoy, Marc Charette, and Seth P. Finklestein

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ECASS: lessons for future thrombolytic stroke trials. European Cooperative Acute Stroke Study, Marc Fisher, Michael S. Pessin, and Anthony J. Furian

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Cortical blindness after correction of symptomatic hyponatremia: dynamic cerebral dysfunction visualized using serial SPECT scanning, Catherine Hagerty, Robert Licho, and Lawrence D. Recht

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Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain, Yasuhiro Hasegawa, Lawrence L. Latour, James E. Formato, Christopher H. Sotak, and Marc Fisher

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Spatial consequences of defective processing of specific yeast mRNAs revealed by fluorescent in situ hybridization, Randall R. Long, David J. Elliott, Francoise Stutz, Michael Rosbash, and Robert H. Singer

Role of the dorsomedial nucleus of the thalamus in Alzheimer's disease, James F. Paskavitz, Carol F. Lippa, James E. Hamos, D. Pulaski-Salo, and David A. Drachman

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Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model, W. Reith, Yasuhiro Hasegawa, Lawrence L. Latour, Bernard J. Dardzinski, Christopher H. Sotak, and Marc Fisher

Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know, Sudha Seshadri, David A. Drachman, and Carol F. Lippa

Publications from 1994

Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume, Ronald A. Cohen, Yasuhiro Hasegawa, and Marc Fisher

Dizziness, David A. Drachman

If we live long enough, will we all be demented, David A. Drachman

Neurological Evaluation in the Elderly Patient, David A. Drachman, Randall R. Long, and Joan M. Swearer

Clinical Atlas of Cerebrovascular Disorders, Marc Fisher

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Prophylactic neuroprotection for cerebral ischemia, Marc Fisher, Saran Jonas, and Ralph L. Sacco

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The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke, Yasuhiro Hasegawa, Marc Fisher, Bruce M. Baron, and Geoffrey Metcalf

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MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia, Yasuhiro Hasegawa, Marc Fisher, Lawrence L. Latour, Bernard J. Dardzinski, and Christopher H. Sotak

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Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats, Yasuhiro Hasegawa, Lawrence L. Latour, Christopher H. Sotak, Bernard J. Dardzinski, and Marc Fisher

Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain, Lawrence L. Latour, Yasuhiro Hasegawa, James E. Formato, Marc Fisher, and Christopher H. Sotak

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Retrograde axonal transport and lesion-induced upregulation of the TrkA high-affinity NGF receptor, Rebekah Loy, Mahesh B. Lachyankar, Peter J. Condon, Dorota K. Poluha, and Alonzo H. Ross

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Dynamics of synapsin I gene expression during the establishment and restoration of functional synapses in the rat hippocampus, Richard H. Melloni, Paul J. Apostolides, James E. Hamos, and Louis J. DeGennaro

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Temporal onset of synapsin I gene expression coincides with neuronal differentiation during the development of the nervous system, Richard H. Melloni and Louis J. DeGennaro

Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium, Takehide Tsuda, Robert F. Lopez-Alberola, Evgeny A. Rogaeva, Morris Freedman, Evgeny I. Rogaev, David A. Drachman, Daniel A. Pollen, Jonathan L. Haines, Y. Liang, and Donald R. McLachlan

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Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management, John P. Weaver and Marc Fisher

Publications from 1993

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Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging, Bernard J. Dardzinski, Christopher H. Sotak, Marc Fisher, Yasuhiro Hasegawa, Lirnin Li, and Kazuo Minematsu

Antimicrobial prophylaxis after tick bites, David A. Drachman

New criteria for the diagnosis of vascular dementia: do we know enough yet, David A. Drachman

Overview of Geriatric Neurology, David A. Drachman and Laurie Barclay

Driving and Alzheimer's disease: the risk of crashes, David A. Drachman and Joan M. Swearer

The Selection of Drugs for the Treatment of Memory Disorders, David A. Drachman and Joan M. Swearer

Current Review of Cerebrovascular Disease, Marc Fisher and Julien Bogousslavsky

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Evolving toward effective therapy for acute ischemic stroke, Marc Fisher and Julien Bogousslavsky

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Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A, Marc Fisher, Gregory M. Plante, and Elizabeth M. Doyle

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Vascular amyloid deposition in Alzheimer's disease. Neither necessary nor sufficient for the local formation of plaques or tangles, Carol F. Lippa, James E. Hamos, Thomas W. Smith, Donna Pulaski-Salo, and David A. Drachman

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Synapsin I gene expression in the adult rat brain with comparative analysis of mRNA and protein in the hippocampus, Richard H. Melloni, Liza M. Hemmendinger, James E. Hamos, and Louis J. DeGennaro

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Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI, Kazuo Minematsu, Marc Fisher, L. Li, Michael A. Davis, A. G. Knapp, R. E. Cotter, R. N. McBurney, and Christopher H. Sotak

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Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats, Kazuo Minematsu, Marc Fisher, Limin Li, and Christopher H. Sotak

Electrical source analysis of auditory ERPs in medial temporal lobe amnestic syndrome, Brian F. O'Donnell, Ronald A. Cohen, Hiroto Hokama, B. Neil Cuffin, Carol F. Lippa, Martha E. Shenton, and David A. Drachman

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Hypermagnesemic pseudocoma, Marco A. Rizzo, Marc Fisher, and J. Paul Lock

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Specific, temporally regulated expression of the insulin-like growth factor II gene during muscle cell differentiation, Kenneth M. Rosen, Bruce Martin Wentworth, Nadia Rosenthal, and Lydia Villa-Komaroff

Publications from 1992

A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group, K. L. Davis, Leon J. Thal, E. R. Gamzu, C. S. Davis, R. F. Woolson, S. I. Gracon, David A. Drachman, L. S. Schneider, P. J. Whitehouse, and T. M. Hoover

The etiology of Alzheimer's disease: the pathogenesis of dementia. The role of neurotoxins, David A. Drachman and Carol F. Lippa

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Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117, Marc Fisher and Margaret M. Arpano

Lacunar stroke: diagnosis, evaluation, and management, Marc Fisher and Kazuo Minematsu