This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurology.

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Publications from 2004

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Microsphere-induced embolic stroke: an MRI study, Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Marc Fisher, Yoram Cohen, and Christopher H. Sotak

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Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia, Xiangjun Meng, Marc Fisher, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong

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Antiplatelet treatment for secondary prevention of acute ischemic stroke and transient ischemic attacks: mechanisms, choices and possible emerging patterns of use, Majaz Moonis and Marc Fisher

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Antihypertensive medications for risk reduction of first and recurrent ischemic stroke, Vasantha Padma, Marc Fisher, and Majaz Moonis

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Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model, Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, Marc Fisher, and Timothy Q. Duong

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Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging, Qiang Shen, Marc Fisher, Christopher H. Sotak, and Timothy Q. Duong

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Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data, Qiang Shen, Hongxia Ren, Marc Fisher, James P. Bouley, and Timothy Q. Duong

Publications from 2003

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Lateralization of circadian pacemaker output: Activation of left- and right-sided luteinizing hormone-releasing hormone neurons involves a neural rather than a humoral pathway, Horacio O. de la Iglesia, Jennifer Meyer, and William J. Schwartz

Preventing and treating Alzheimer’s disease: strategies and prospects, David A. Drachman

Imaging as a Surrogate Marker in Clinical Trials, Marc Fisher

Ongoing Trials and Future Directions for Acute Ischemic Stroke Treatment, Marc Fisher

Ongoing trials and future directions for acute ischemic stroke treatment, Marc Fisher

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Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Marc Fisher

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Stem cell transplantation for stroke: does it work, and if so, how, Marc Fisher

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The ischemic penumbra: identification, evolution and treatment concepts, Marc Fisher

Using Diffusion-Perfusion MRI in Animal Models for Drug Development, Marc Fisher

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Emerging therapies for acute ischemic stroke: new therapies on trial, Marc Fisher and Thomas G. Brott

Magnetic Resonance Imaging in Stroke, Marc Fisher, Stephen Davis, and Steven Warach

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Combination Therapies, Restorative Therapies and Future Directions, Marc Fisher and Majaz Moonis

Neurovascular Disorders, Marc Fisher, E. Orberk, and M. Ramzan

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New perspectives on developing acute stroke therapy, Marc Fisher and Rajiv Ratan

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The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats, Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, Christopher H. Sotak, and Marc Fisher

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Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance, Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, Georg Bachmann, and Marc Fisher

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Sensory regulation of swallowing and airway protection: a role for the internal superior laryngeal nerve in humans, Samah Jafari, Rebecca A. Prince, Daniel Y. Kim, and David Paydarfar

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Explicit neural representations, recursive neural networks and conscious visual perception, Daniel A. Pollen

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Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia, Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, Fuhai Li, and Marc Fisher

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Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging, Qiang Shen, Xiangjun Meng, Marc Fisher, Christopher H. Sotak, and Timothy Q. Duong

Publications from 2002

Hat size, brain size, intelligence, and dementia: what morphometry can tell us about brain function and disease, David A. Drachman

The treatment of Alzheimer's disease: where have we been, and where are we going, David A. Drachman

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Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis, Lawrence J. Hayward, Jorge A. Rodriguez, Ji W. Kim, Ashutosh Tiwari, Joy J. Goto, Diane E. Cabelli, Joan Selverstone Valentine, and Robert H. Brown Jr.

Dementia, butterfly ballots, and voter competence, Victor W. Henderson and David A. Drachman

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Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats, Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, Christopher H. Sotak, and Marc Fisher

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Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke, Majaz Moonis and Marc Fisher

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Spatial receptive field organization of macaque V4 neurons, Daniel A. Pollen, Andrzej W. Przybyszewski, Mark A. Rubin, and Warren Foote

Aging and Dementia: principles, evaluation and diagnosis, Sudha Seshadri and David A. Drachman

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Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain, Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, Marc Fisher, and Christopher H. Sotak

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Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction, Ashutosh Tiwari and Lawrence J. Hayward

Publications from 2001

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Educating the next generation of physicians about stroke: incorporating stroke prevention into the medical school curriculum, Susan Billings-Gagliardi, Nancy M. Fontneau, Merrill K. Wolf, Susan V. Barrett, George J. Hademenos, and Kathleen M. Mazor

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Practice Parameters: Diagnosis, Treatment, and Early Detection of Dementia, David A. Drachman

Stroke Therapy (2nd ed.), Marc Fisher

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Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia, Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, Marc Fisher, and Joseph D. Fenstermacher

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Neural precursor cells form rudimentary tissue-like structures in a rotating-wall vessel bioreactor, Hoi Pang Low, Todd M. Savarese, and William J. Schwartz

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Towards the reconstruction of central nervous system white matter using neural precursor cells, Masato Mitome, Hoi Pang Low, Anthony van den Pol, John J. Nunnari, Merrill K. Wolf, Susan Billings-Gagliardi, and William J. Schwartz

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Imaging of acute stroke, Majaz Moonis and Marc Fisher

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Ataxia associated with Hashimoto's disease: progressive non-familial adult onset cerebellar degeneration with autoimmune thyroiditis, Magdy H. Selim and David A. Drachman

Postmenopausal estrogen replacement therapy and the risk of Alzheimer disease, Sudha Seshadri, Gwen L. Zornberg, Laura E. Derby, Marian W. Myers, Hershel Jick, and David A. Drachman

Psychological features in persons at risk for familial Alzheimer's disease, Joan M. Swearer, Brian F. O'Donnell, Michael Parker, Kevin J. Kane, and David A. Drachman

Publications from 2000

Alzheimer's disease: what is it, how many people have it, and why do we need to know, Marilyn S. Albert and David A. Drachman

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Patients with acute stroke: recent developments in neuroimaging, Pierre C. Combremont and Marc Fisher

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Antiphase oscillation of the left and right suprachiasmatic nuclei, Horacio O. de la Iglesia, Jennifer Meyer, Alan Carpino, and William J. Schwartz

Occam's razor, geriatric syndromes, and the dizzy patient, David A. Drachman

Current Review of Cerebrovascular Disease (4th ed.), Marc Fisher and Julien Bogousslavsky

Prevention of Ischemic Stroke, Marc Fisher and Cesare Fieschi

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An overview of acute stroke therapy: past, present, and future, Marc Fisher and Wolf-Rudiger Schabitz

Statins and the risk of dementia, Hershel Jick, Gwen L. Zornberg, Susan S. Jick, Sudha Seshadri, and David A. Drachman

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A role for nuclear PTEN in neuronal differentiation, Mahesh B. Lachyankar, Nazneen Sultana, Christopher M. Schonhoff, Prasenjit Mitra, Wojciech Poluha, Stephen Lambert, Peter J. Quesenberry, N. Scott Litofsky, Lawrence D. Recht, Roya Nabi, Susan J. Miller, Shinji Ohta, Benjamin G. Neel, and Alonzo H. Ross

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Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats, Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, Christopher H. Sotak, and Marc Fisher

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Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI, Fuhai Li, Matthew D. Silva, Christopher H. Sotak, and Marc Fisher

Familial Alzheimer's disease: site of mutation influences clinical phenotype, Carol F. Lippa, Joan M. Swearer, Kevin J. Kane, David Nochlin, Thomas D. Bird, Bernardino Ghetti, Linda Nee, Peter H. St. George-Hyslop, Daniel A. Pollen, and David A. Drachman

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The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats, Wolf-Rudiger Schabitz, Fuhai Li, and Marc Fisher

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Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat, Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, Uwe Pschorn, and Marc Fisher

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Quantitative analysis of the loss of distinction between gray and white matter in comatose patients after cardiac arrest, Michel T. Torbey, Magdy H. Selim, John R. Knorr, Carol Bigelow, and Lawrence D. Recht

Publications from 1999

A 69-year-old man with chronic dizziness, David A. Drachman

Risk factors for seizure-related motor vehicle crashes in patients with epilepsy, David A. Drachman

Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-1999. A 67-year-old man with three years of dementia, David A. Drachman and Kathy L. Newell

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Antithrombotic and thrombolytic therapy for ischemic stroke, Marc Fisher

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Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke, Marc Fisher and Gregory W. Albers

Current Review of Cerebrovascular Disease (3rd ed.), Marc Fisher and Julien Bogousslavsky

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Pharmacological approaches to stroke recovery, Marc Fisher and Seth P. Finklestein

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Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats, Fuhai Li, Sam S. Han, Turgut Tatlisumak, Kai-Feng Liu, Julio H. Garcia, Christopher H. Sotak, and Marc Fisher

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Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats, Fuhai Li, Tsuyoshi Omae, and Marc Fisher

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On the neural correlates of visual perception, Daniel A. Pollen

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Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia, Wolf-Rudiger Schabitz, Fuhai Li, Katsumi Irie, Bobby W. Sandage, Kenneth W. Locke, and Marc Fisher

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Myocardial infarction, seizure and an abnormal head CT scan, Nithianandam Selvaraj, David A. Drachman, Paula D. Ravin, and John R. Knorr

Publications from 1998

From capitation to rhinocitation, Jeffrey D. Bernhard and David A. Drachman

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A first-year minicurriculum on TIA/stroke, Susan Billings-Gagliardi, Nancy M. Fontneau, and Michele P. Pugnaire

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Determination of focal ischemic lesion volume in the rat brain using multispectral analysis, Richard A.D. Carano, Kentaro Takano, Karl G. Helmer, Turgut Tatlisumak, Katsumi Irie, Joseph D. Petruccelli, Marc Fisher, and Christopher H. Sotak

Degenerative Dementias, David A. Drachman and Joan M. Swearer

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The travails of neuroprotective drug development for acute ischemic stroke, Marc Fisher

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Further evolution toward effective therapy for acute ischemic stroke, Marc Fisher and Julien Bogousslavsky

Textbook of Neurology, Marc Fisher and Julien Bogousslavsky

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A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging, Fuhai Li, Sam S. Han, Turgut Tatlisumak, Richard A.D. Carano, Katsumi Irie, Christopher H. Sotak, and Marc Fisher

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Amastigote surface proteins of Trypanosoma cruzi are targets for CD8+ CTL, Hoi Pang Low, Maria A. M. Santos, Benjamin Wizel, and Rick L. Tarleton

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Phase resetting of the respiratory oscillator by carotid sinus nerve stimulation in cats, David Paydarfar, Frederic L. Eldridge, and Joseph A. Paydarfar

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Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging, Kentaro Takano, Richard A.D. Carano, Turgut Tatlisumak, Michael R. Meiler, Christopher H. Sotak, H. D. Kleinert, and Marc Fisher

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A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study, Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Terry J. Opgenorth, Christopher H. Sotak, and Marc Fisher

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Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion, Turgut Tatlisumak, Kentaro Takano, Richard A.D. Carano, Leonard P. Miller, Alan C. Foster, and Marc Fisher

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A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion, Turgut Tatlisumak, Kentaro Takano, Michael R. Meiler, and Marc Fisher

Publications from 1997

Aging and the brain: a new frontier, David A. Drachman

Treatment of Alzheimer's disease -- searching for a breakthrough, settling for less, David A. Drachman and Paul Leber

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Carvedilol inhibits aortic lipid deposition in the hypercholesterolemic rat, Giora Z. Feuerstein, Marc Fisher, John J. Nunnari, and Robert R. Ruffolo Jr.

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Characterizing the target of acute stroke therapy, Marc Fisher

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Embryonic precursor cells that express Trk receptors: induction of different cell fates by NGF, BDNF, NT-3, and CNTF, Mahesh B. Lachyankar, Peter J. Condon, Peter J. Quesenberry, N. Scott Litofsky, Lawrence D. Recht, and Alonzo H. Ross

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TrkA expression decreases the in vivo aggressiveness of C6 glioma cells, Mahesh B. Lachyankar, Alonzo H. Ross, N. Scott Litofsky, Peter J. Condon, Peter J. Quesenberry, and Lawrence D. Recht

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Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model, Fuhai Li, Katsumi Irie, M. Sawkat Anwer, and Marc Fisher

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Molecular cloning of the gene encoding the 83 kDa amastigote surface protein and its identification as a member of the Trypanosoma cruzi sialidase superfamily, Hoi Pang Low and Rick L. Tarleton

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Dde-I restriction endonuclease fragmentation: a novel method of generating cDNA probes for in situ hybridization in brain, Richard H. Melloni, Neil Aronin, Louis J. DeGennaro, Craig F. Ferris, and Robert J. Harrison

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Acute ischemic stroke therapy. A clinical overview, M. Zulkuf Onal and Marc Fisher

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Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats, M. Zulkuf Onal, Fuhai Li, Turgut Tatlisumak, Kenneth W. Locke, Bobby W. Sandage Jr., and Marc Fisher

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Caretaker Obstreperous Behavior Rating Scale, Joan M. Swearer and David A. Drachman