This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurology.

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Publications from 2005

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Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model, Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, Rajiv Ratan, and Marc Fisher

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Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution, Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, Timothy Q. Duong, and Marc Fisher

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Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging, Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, Timothy Q. Duong, and Marc Fisher

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Development and validation of the stroke action test, Susan Billings-Gagliardi and Kathleen M. Mazor

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Emerging therapies for cerebrovascular disorders, Antonio Davalos and Marc Fisher

Commentary on “Diagnosis of Alzheimer’s disease: Two decades of progress.” Alzheimer’s Disease: Years of Progress, and an Army of Researchers Recruited; AD Remains an Elusive Adversary, David A. Drachman

Do we have brain to spare, David A. Drachman

Analysis of Acute Perihematomal Edema in Warfarin-Related Intracerebral Hemorrhage, David Finkelstein

Developing and implementing future stroke therapies: the potential of telemedicine, Marc Fisher

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Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable, Marc Fisher, Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler

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Use of animal models has not contributed to development of acute stroke therapies: con, Marc Fisher and Turgut Tatlisumak

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Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke, Anthony J. Furlan and Marc Fisher

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Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging, Erica C. Henning, Xiangjun Meng, Marc Fisher, and Christopher H. Sotak

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Impaired spatial learning in a novel rat model of mild cerebral concussion injury, Nils Henninger, Stephan Dutzmann, Kenneth M. Sicard, Rainer Kollmar, Juergen F. Bardutzky, and Stefan Schwab

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome, Majaz Moonis, Kevin J. Kane, Ute Schwiderski, Bobby W. Sandage, and Marc Fisher

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Myelination and long diffusion times alter diffusion-tensor-imaging contrast in myelin-deficient shiverer mice, Govind Nair, Yusuke Tanahashi, Hoi Pang Low, Susan Billings-Gagliardi, William J. Schwartz, and Timothy Q. Duong

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Thrombolytic therapy for acute ischemic stroke: 3 h and beyond, Vasantha Padma, Marc Fisher, and Majaz Moonis

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Isolation of immortalized, INK4a/ARF-deficient cells from the subventricular zone after in utero N-ethyl-N-nitrosourea exposure, Todd M. Savarese, Taichang Jang, Hoi Pang Low, Rebecca Salmonsen, N. Scott Litofsky, Zdenka Matijasevic, Alonzo H. Ross, and Lawrence D. Recht

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Functional, perfusion and diffusion MRI of acute focal ischemic brain injury, Qiang Shen, Hongxia Ren, Haiying Cheng, Marc Fisher, and Timothy Q. Duong

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Statistical prediction of tissue fate in acute ischemic brain injury, Qiang Shen, Hongxia Ren, Marc Fisher, and Timothy Q. Duong

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c-Fos expression in the brains of behaviorally "split" hamsters in constant light: calling attention to a dorsolateral region of the suprachiasmatic nucleus and the medial division of the lateral habenula, Mahboubeh Tavakoli-Nezhad and William J. Schwartz

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Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis, Ashutosh Tiwari, Zuoshang Xu, and Lawrence J. Hayward

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Inhibition of chaperone activity is a shared property of several Cu,Zn-superoxide dismutase mutants that cause amyotrophic lateral sclerosis, Hemachand Tummala, Chelowha Jung, Ashutosh Tiwari, Cynthia M. J. Higgins, Lawrence J. Hayward, and Zuoshang Xu

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Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy, Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, Ralph L. Sacco, and Marc Fisher

Publications from 2004

The aging factor in health and disease: the promise of basic research on aging, Robert N. Butler, Huber R. Warner, T. Franklin Williams, Steven N. Austad, Jacob A. Brody, Judith Campisi, Anthony Cerami, Gene D. Cohen, Vincent J. Cristofalo, David A. Drachman, Caleb E. Finch, Irwin Fridovich, Calvin B. Harley, Richard J. Havlik, George M. Martin, Richard A. Miller, S. Jay Olshansky, Olivia M. Pereira-Smith, James R. Smith, Richard L. Sprott, Michael D. West, John R. Wilmoth, and Woodring E. Wright

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Structural basis of heteromeric smad protein assembly in TGF-beta signaling, Benoy Maramparambil Chacko, Bin Y. Qin, Ashutosh Tiwari, Genbin Shi, Suvana S. Lam, Lawrence J. Hayward, Mark De Caestecker, and Kai Lin

Fading Minds and Hanging Chads: Alzheimer’s Disease and the Right to Vote, David A. Drachman

Statins in the Prevention and Treatment of Alzheimer’s Disease, David A. Drachman

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Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke, Timothy Q. Duong and Marc Fisher

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Emerging therapies for cerebrovascular disorders, Marc Fisher and Antonio Davalos

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The MATCH study results in the context of secondary stroke prevention, Marc Fisher and Antonio Davalos

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Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging, Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Marc Fisher, Manfred Kaps, and Georg Bachmann

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Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats, Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, Marc Fisher, and Georg Bachmann

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Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography, Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, Marc Fisher, and Georg Bachmann

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Differentiation prevents assessment of neural stem cell pluripotency after blastocyst injection, Beatrice Greco, Hoi Pang Low, Eric C. Johnson, Rebecca Salmonsen, Judith Gallant, Stephen N. Jones, Alonzo H. Ross, and Lawrence D. Recht

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Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats, Mark Kazemi, Matthew D. Silva, Fuhai Li, Marc Fisher, and Christopher H. Sotak

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Microsphere-induced embolic stroke: an MRI study, Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Marc Fisher, Yoram Cohen, and Christopher H. Sotak

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Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia, Xiangjun Meng, Marc Fisher, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong

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Antiplatelet treatment for secondary prevention of acute ischemic stroke and transient ischemic attacks: mechanisms, choices and possible emerging patterns of use, Majaz Moonis and Marc Fisher

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Antihypertensive medications for risk reduction of first and recurrent ischemic stroke, Vasantha Padma, Marc Fisher, and Majaz Moonis

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Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model, Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, Marc Fisher, and Timothy Q. Duong

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Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging, Qiang Shen, Marc Fisher, Christopher H. Sotak, and Timothy Q. Duong

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Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data, Qiang Shen, Hongxia Ren, Marc Fisher, James P. Bouley, and Timothy Q. Duong

Publications from 2003

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Lateralization of circadian pacemaker output: Activation of left- and right-sided luteinizing hormone-releasing hormone neurons involves a neural rather than a humoral pathway, Horacio O. de la Iglesia, Jennifer Meyer, and William J. Schwartz

Preventing and treating Alzheimer’s disease: strategies and prospects, David A. Drachman

Imaging as a Surrogate Marker in Clinical Trials, Marc Fisher

Ongoing Trials and Future Directions for Acute Ischemic Stroke Treatment, Marc Fisher

Ongoing trials and future directions for acute ischemic stroke treatment, Marc Fisher

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Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Marc Fisher

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Stem cell transplantation for stroke: does it work, and if so, how, Marc Fisher

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The ischemic penumbra: identification, evolution and treatment concepts, Marc Fisher

Using Diffusion-Perfusion MRI in Animal Models for Drug Development, Marc Fisher

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Emerging therapies for acute ischemic stroke: new therapies on trial, Marc Fisher and Thomas G. Brott

Magnetic Resonance Imaging in Stroke, Marc Fisher, Stephen Davis, and Steven Warach

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Combination Therapies, Restorative Therapies and Future Directions, Marc Fisher and Majaz Moonis

Neurovascular Disorders, Marc Fisher, E. Orberk, and M. Ramzan

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New perspectives on developing acute stroke therapy, Marc Fisher and Rajiv Ratan

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The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats, Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, Christopher H. Sotak, and Marc Fisher

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Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance, Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, Georg Bachmann, and Marc Fisher

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Sensory regulation of swallowing and airway protection: a role for the internal superior laryngeal nerve in humans, Samah Jafari, Rebecca A. Prince, Daniel Y. Kim, and David Paydarfar

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Explicit neural representations, recursive neural networks and conscious visual perception, Daniel A. Pollen

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Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia, Victor E. Shashoua, David S. Adams, Anne Boyer-Boiteau, Ann Cornell-Bell, Fuhai Li, and Marc Fisher

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Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging, Qiang Shen, Xiangjun Meng, Marc Fisher, Christopher H. Sotak, and Timothy Q. Duong

Publications from 2002

Hat size, brain size, intelligence, and dementia: what morphometry can tell us about brain function and disease, David A. Drachman

The treatment of Alzheimer's disease: where have we been, and where are we going, David A. Drachman

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Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis, Lawrence J. Hayward, Jorge A. Rodriguez, Ji W. Kim, Ashutosh Tiwari, Joy J. Goto, Diane E. Cabelli, Joan Selverstone Valentine, and Robert H. Brown Jr.

Dementia, butterfly ballots, and voter competence, Victor W. Henderson and David A. Drachman

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Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats, Fuhai Li, Kai-Feng Liu, Matthew D. Silva, Xiangjun Meng, Tibo Gerriets, Karl G. Helmer, Joseph D. Fenstermacher, Christopher H. Sotak, and Marc Fisher

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Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke, Majaz Moonis and Marc Fisher

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Spatial receptive field organization of macaque V4 neurons, Daniel A. Pollen, Andrzej W. Przybyszewski, Mark A. Rubin, and Warren Foote

Aging and Dementia: principles, evaluation and diagnosis, Sudha Seshadri and David A. Drachman

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Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain, Matthew D. Silva, Tsuyoshi Omae, Karl G. Helmer, Fuhai Li, Marc Fisher, and Christopher H. Sotak

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Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction, Ashutosh Tiwari and Lawrence J. Hayward

Publications from 2001

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Educating the next generation of physicians about stroke: incorporating stroke prevention into the medical school curriculum, Susan Billings-Gagliardi, Nancy M. Fontneau, Merrill K. Wolf, Susan V. Barrett, George J. Hademenos, and Kathleen M. Mazor

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Practice Parameters: Diagnosis, Treatment, and Early Detection of Dementia, David A. Drachman

Stroke Therapy (2nd ed.), Marc Fisher

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Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia, Kai-Feng Liu, Fuhai Li, Turgut Tatlisumak, Julio H. Garcia, Christopher H. Sotak, Marc Fisher, and Joseph D. Fenstermacher

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Neural precursor cells form rudimentary tissue-like structures in a rotating-wall vessel bioreactor, Hoi Pang Low, Todd M. Savarese, and William J. Schwartz

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Towards the reconstruction of central nervous system white matter using neural precursor cells, Masato Mitome, Hoi Pang Low, Anthony van den Pol, John J. Nunnari, Merrill K. Wolf, Susan Billings-Gagliardi, and William J. Schwartz

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Imaging of acute stroke, Majaz Moonis and Marc Fisher

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Ataxia associated with Hashimoto's disease: progressive non-familial adult onset cerebellar degeneration with autoimmune thyroiditis, Magdy H. Selim and David A. Drachman

Postmenopausal estrogen replacement therapy and the risk of Alzheimer disease, Sudha Seshadri, Gwen L. Zornberg, Laura E. Derby, Marian W. Myers, Hershel Jick, and David A. Drachman

Psychological features in persons at risk for familial Alzheimer's disease, Joan M. Swearer, Brian F. O'Donnell, Michael Parker, Kevin J. Kane, and David A. Drachman

Publications from 2000

Alzheimer's disease: what is it, how many people have it, and why do we need to know, Marilyn S. Albert and David A. Drachman

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Patients with acute stroke: recent developments in neuroimaging, Pierre C. Combremont and Marc Fisher

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Antiphase oscillation of the left and right suprachiasmatic nuclei, Horacio O. de la Iglesia, Jennifer Meyer, Alan Carpino, and William J. Schwartz

Occam's razor, geriatric syndromes, and the dizzy patient, David A. Drachman

Current Review of Cerebrovascular Disease (4th ed.), Marc Fisher and Julien Bogousslavsky

Prevention of Ischemic Stroke, Marc Fisher and Cesare Fieschi

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An overview of acute stroke therapy: past, present, and future, Marc Fisher and Wolf-Rudiger Schabitz

Statins and the risk of dementia, Hershel Jick, Gwen L. Zornberg, Susan S. Jick, Sudha Seshadri, and David A. Drachman

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A role for nuclear PTEN in neuronal differentiation, Mahesh B. Lachyankar, Nazneen Sultana, Christopher M. Schonhoff, Prasenjit Mitra, Wojciech Poluha, Stephen Lambert, Peter J. Quesenberry, N. Scott Litofsky, Lawrence D. Recht, Roya Nabi, Susan J. Miller, Shinji Ohta, Benjamin G. Neel, and Alonzo H. Ross

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Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats, Fuhai Li, Matthew D. Silva, Kai-Feng Liu, Karl G. Helmer, Tsuyoshi Omae, Joseph D. Fenstermacher, Christopher H. Sotak, and Marc Fisher

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Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI, Fuhai Li, Matthew D. Silva, Christopher H. Sotak, and Marc Fisher

Familial Alzheimer's disease: site of mutation influences clinical phenotype, Carol F. Lippa, Joan M. Swearer, Kevin J. Kane, David Nochlin, Thomas D. Bird, Bernardino Ghetti, Linda Nee, Peter H. St. George-Hyslop, Daniel A. Pollen, and David A. Drachman

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The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats, Wolf-Rudiger Schabitz, Fuhai Li, and Marc Fisher

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Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat, Turgut Tatlisumak, Richard A.D. Carano, Kentaro Takano, Michael R. Meiler, Fuhai Li, Christopher H. Sotak, Dietrich Arndts, Uwe Pschorn, and Marc Fisher

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Quantitative analysis of the loss of distinction between gray and white matter in comatose patients after cardiac arrest, Michel T. Torbey, Magdy H. Selim, John R. Knorr, Carol Bigelow, and Lawrence D. Recht

Publications from 1999

A 69-year-old man with chronic dizziness, David A. Drachman

Risk factors for seizure-related motor vehicle crashes in patients with epilepsy, David A. Drachman