This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurology.

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Publications from 2008

Memory and the brain: beyond intracranial phrenology, David A. Drachman

Nature or nurture: education and the trajectory of declining brain function with age and Alzheimer disease, David A. Drachman

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Thunderclap headache and normal computed tomographic results: value of cerebrospinal fluid analysis, Stefan A. Dupont, Eelco F. M. Wijdicks, Edward M. Manno, and Alejandro A. Rabinstein

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Advances in Stroke 2007: introduction, Marc Fisher

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Stroke and TIA: epidemiology, risk factors, and the need for early intervention, Marc Fisher

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Treating acute ischemic stroke, Marc Fisher and Birgül Bastan

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Acute ischemic coronary artery disease and ischemic stroke: similarities and differences, Marc Fisher and Edward Folland

Evaluating the Patient with Altered Consciousness in the Intensive Care Unit, Lawrence J. Hayward and David A. Drachman

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Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness, Lawrence J. Hayward, Joanna S. Kim, Ming-Yang Lee, Hongru Zhou, Ji W. Kim, Kumudini Misra, Mohammad Salajegheh, Fen-fen Wu, Shinji Matsuda, Valerie Reid, Didier Cros, Eric P. Hoffman, Jean-Marc Renaud, Stephen C. Cannon, and Robert H. Brown

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Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke, Nils Henninger, James P. Bouley, Bernt T. Bratane, Birgül Bastan, Meghan Shea, and Marc Fisher

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Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model, Nils Henninger, Bernt T. Bratane, Birgül Bastan, James P. Bouley, and Marc Fisher

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Listening to the New Student Voice: How They Learn, Stacey J. Kadish, Gina M. Gentile, Susan V. Barrett, Mary L. Zanetti, Thomas W. Smith, and Michele P. Pugnaire

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Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection, Brett Langley, Melissa A. D'Annibale, Kyungsun Suh, Issam Ayoub, Aaron Tolhurst, Birgül Bastan, Lichuan Yang, Brian Ko, Marc Fisher, Sunghee Cho, M. Flint Beal, and Rajiv R. Ratan

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Good laboratory practice: preventing introduction of bias at the bench, Malcolm R. Macleod, Marc Fisher, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M.W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, and David W. Howells

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A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype, Concetta G. A. Marfella, Nils Henninger, Scott E. LeBlanc, Namrata Krishnan, David S. Garlick, Lawrence B. Holzman, and Anthony N. Imbalzano

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Neuronal differentiation of EGF-propagated neurosphere cells after engraftment to the nucleus of the solitary tract, Masato Mitome, Hoi Pang Low, Karen M. Lora Rodriguez, Masafumi Kitamoto, Takamasa Kitamura, and William J. Schwartz

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Dantrolene mediates vasorelaxation in cerebral vasoconstriction: a case series, Susanne Muehlschlegel, Guy A. Rordorf, Michael J. Bodock, and John R. Sims

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Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit, Susanne Muehlschlegel and John R. Sims

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Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials, Maria Philip, Michael Benatar, Marc Fisher, and Sean I. Savitz

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Dilemmas in the management of atrial fibrillation in chronic kidney disease, Holger Reinecke, Eva Brand, Rolf Mesters, Wolf-Rüdiger Schäbitz, Marc Fisher, Hermann Pavenstädt, and Günter Breithardt

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Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices, Sean I. Savitz, Michael Benatar, Jeffrey L. Saver, and Marc Fisher

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Correlation of umbilical cord blood haematopoietic stem and progenitor cell levels with birth weight: implications for a prenatal influence on cancer risk, William C. Strohsnitter, Todd M. Savarese, Hoi Pang Low, David P. Chelmow, Pagona Lagiou, Mats Lambe, Kathryn L. Edmiston, Qin Liu, Inkyung Baik, Kenneth L. Noller, Hans-Olov Adami, Dimitrios Trichopoulos, and Chung-Cheng Hsieh

Publications from 2007

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The Virtual International Stroke Trials Archive, Myzoon Ali, Philip M.W. Bath, John Curram, Stephen M. Davis, Hans-Christoph Diener, Geoffrey A. Donnan, Marc Fisher, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L. Sacco, Philip Teal, Nils-Gunnar Wahlgren, Steven Warach, Christopher J. Weir, and Kennedy R. Lees

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Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging, Juergen F. Bardutzky, Qiang Shen, Nils Henninger, Stefan Schwab, Timothy Q. Duong, and Marc Fisher

Rethinking Alzheimer's disease: the role of age-related changes, David A. Drachman

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Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes, Marc Fisher, Daniel F. Hanley, George Howard, Edward C. Jauch, and Steven Warach

Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials, Marc Fisher and Nils Henninger

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Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model, Romolo Joseph Gaspari and David Paydarfar

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Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats, Nils Henninger, James P. Bouley, Julia M. Nelligan, Kenneth M. Sicard, and Marc Fisher

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Spatial learning induces predominant downregulation of cytosolic proteins in the rat hippocampus, Nils Henninger, R. E. Feldmann Jr, C. D. Futterer, C. Schrempp, M. H. Maurer, K. F. Waschke, W. Kuschinsky, and Stefan Schwab

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Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke, Nils Henninger and Marc Fisher

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Electrophysiology and neuronal integrity following systemic arterial hypotension in a rat model of unilateral carotid artery occlusion, Nils Henninger, Axel Heimann, and Oliver Kempski

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Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats, Nils Henninger, Kenneth M. Sicard, and Marc Fisher

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Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat, Nils Henninger, Kenneth M. Sicard, Zhixin Li, Praveen P. Kulkarni, Stephan Dutzmann, Christian Urbanek, Stefan Schwab, and Marc Fisher

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Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats, Nils Henninger, Qi Wang, Jurgen G. Okun, Stefan Schwab, and Martin Krause

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Statins differentially affect amyloid precursor protein metabolism in presymptomatic PS1 and non-PS1 subjects, Douglas A. Hinerfeld, Majaz Moonis, Joan M. Swearer, Stephen P. Baker, Richard J. Caselli, Ekaterina Rogaeva, Peter St. George-Hyslop, and Daniel A. Pollen

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Design principles for phase-splitting behaviour of coupled cellular oscillators: clues from hamsters with 'split' circadian rhythms, Premananda Indic, William J. Schwartz, and David Paydarfar

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Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1), Yair Lampl, Justin A. Zivin, Marc Fisher, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron

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Tracking the seasons: the internal calendars of vertebrates, Matthew J. Paul, Irving Zucker, and William J. Schwartz

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Normal breast stem cells, malignant breast stem cells, and the perinatal origin of breast cancer, Todd M. Savarese, Hoi Pang Low, Inkyung Baik, William C. Strohsnitter, and Chung-Cheng Hsieh

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Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis, Todd M. Savarese, William C. Strohsnitter, Hoi Pang Low, Qin Liu, Inkyung Baik, William C. Okulicz, David P. Chelmow, Pagona Lagiou, Peter J. Quesenberry, Kenneth L. Noller, and Chung-Cheng Hsieh

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials, Sean I. Savitz and Marc Fisher

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Prophylactic neuroprotection, Sean I. Savitz and Marc Fisher

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Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials, Sean I. Savitz, Robert A. Lew, Erich Bluhmki, Werner Hacke, and Marc Fisher

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Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia, Giles D. J. Watts, Dana Thomasova, Sheena K. Ramdeen, Erin C. Fulchiero, Sarju G. Mehta, David A. Drachman, Conrad C. Weihl, Zygmunt Jamrozik, Hubert Kwiecinski, Anna Kaminska, and Virginia E. Kimonis

Publications from 2006

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Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging, James P. Bouley, Marc Fisher, and Nils Henninger

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Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases, Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Marc Fisher, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong

Aging of the brain, entropy, and Alzheimer disease, David A. Drachman

Robert Katzman and Alzheimer's disease: an appreciation, David A. Drachman

Approaches to Cerebrovascular Disease, Marc Fisher

Identification and Treatment of Stroke Risk Factors, Marc Fisher

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NXY-059 for acute ischemic stroke: the promise of neuroprotection is finally realized, Marc Fisher

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Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Marc Fisher

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The ischemic penumbra: a new opportunity for neuroprotection, Marc Fisher

Imaging in Experimental Neurology, Marc Fisher, Eng H. Lo, and Michael Lev

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Handbook of Experimental Neurology: Methods and Techniques in Animal Research, Marc Fisher and Turgut Tatlisumak

Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations, Mark S. Forman, Ian R. Mackenzie, Nigel J. Cairns, Eric Swanson, Philip J. Boyer, David A. Drachman, Bharati S. Jhaveri, Jason H. Karlawish, Alan Pestronk, Thomas W. Smith, Pang-Hsien Tu, Giles D. J. Watts, William R. Markesbery, Charles D. Smith, and Virginia E. Kimonis

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A new model of thromboembolic stroke in the posterior circulation of the rat, Nils Henninger, Karl H. Eberius, Kenneth M. Sicard, Rainer Kollmar, Clemens Sommer, Stefan Schwab, and Wolf-Rudiger Schabitz

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Normobaric hyperoxia - a promising approach to expand the time window for acute stroke treatment, Nils Henninger and Marc Fisher

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Neuroprotective effect of hyperbaric oxygen therapy monitored by MR-imaging after embolic stroke in rats, Nils Henninger, Lea Kuppers-Tiedt, Kenneth M. Sicard, Albrecht Gunther, Dietmar Schneider, and Stefan Schwab

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The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia, Nils Henninger, Kenneth M. Sicard, James P. Bouley, Marc Fisher, and Nancy E. Stagliano

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Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging, Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, Juergen F. Bardutzky, and Marc Fisher

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Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea, Taichang Jang, Todd M. Savarese, Hoi Pang Low, Sunchin Kim, Hannes Vogel, David S. Lapointe, Timothy Q. Duong, N. Scott Litofsky, James M. Weimann, Alonzo H. Ross, and Lawrence D. Recht

The optic nerve: a window into diseases of the brain, Neil R. Miller and David A. Drachman

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Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke, Vasantha Padma, Marc Fisher, and Majaz Moonis

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Noisy inputs and the induction of on-off switching behavior in a neuronal pacemaker, David Paydarfar, Daniel B. Forger, and John R. Clay

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Perspectives on neuroprotective stroke therapy, Wolf-Rudiger Schabitz and Marc Fisher

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Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats, Kenneth M. Sicard, Nils Henninger, Marc Fisher, Timothy Q. Duong, and Craig F. Ferris

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Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats, Kenneth M. Sicard, Nils Henninger, Marc Fisher, Timothy Q. Duong, and Craig F. Ferris

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Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI), Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Marc Fisher, Georg Bachmann, and Tibo Gerriets

Publications from 2005

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Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model, Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, Rajiv Ratan, and Marc Fisher

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Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution, Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, Timothy Q. Duong, and Marc Fisher

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Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging, Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, Timothy Q. Duong, and Marc Fisher

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Development and validation of the stroke action test, Susan Billings-Gagliardi and Kathleen M. Mazor

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Emerging therapies for cerebrovascular disorders, Antonio Davalos and Marc Fisher

Commentary on “Diagnosis of Alzheimer’s disease: Two decades of progress.” Alzheimer’s Disease: Years of Progress, and an Army of Researchers Recruited; AD Remains an Elusive Adversary, David A. Drachman

Do we have brain to spare, David A. Drachman

Analysis of Acute Perihematomal Edema in Warfarin-Related Intracerebral Hemorrhage, David Finkelstein

Developing and implementing future stroke therapies: the potential of telemedicine, Marc Fisher

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Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable, Marc Fisher, Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler

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Use of animal models has not contributed to development of acute stroke therapies: con, Marc Fisher and Turgut Tatlisumak

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Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke, Anthony J. Furlan and Marc Fisher

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Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging, Erica C. Henning, Xiangjun Meng, Marc Fisher, and Christopher H. Sotak

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Impaired spatial learning in a novel rat model of mild cerebral concussion injury, Nils Henninger, Stephan Dutzmann, Kenneth M. Sicard, Rainer Kollmar, Juergen F. Bardutzky, and Stefan Schwab

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome, Majaz Moonis, Kevin J. Kane, Ute Schwiderski, Bobby W. Sandage, and Marc Fisher

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Myelination and long diffusion times alter diffusion-tensor-imaging contrast in myelin-deficient shiverer mice, Govind Nair, Yusuke Tanahashi, Hoi Pang Low, Susan Billings-Gagliardi, William J. Schwartz, and Timothy Q. Duong

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Thrombolytic therapy for acute ischemic stroke: 3 h and beyond, Vasantha Padma, Marc Fisher, and Majaz Moonis

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Isolation of immortalized, INK4a/ARF-deficient cells from the subventricular zone after in utero N-ethyl-N-nitrosourea exposure, Todd M. Savarese, Taichang Jang, Hoi Pang Low, Rebecca Salmonsen, N. Scott Litofsky, Zdenka Matijasevic, Alonzo H. Ross, and Lawrence D. Recht

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Functional, perfusion and diffusion MRI of acute focal ischemic brain injury, Qiang Shen, Hongxia Ren, Haiying Cheng, Marc Fisher, and Timothy Q. Duong

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Statistical prediction of tissue fate in acute ischemic brain injury, Qiang Shen, Hongxia Ren, Marc Fisher, and Timothy Q. Duong

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c-Fos expression in the brains of behaviorally "split" hamsters in constant light: calling attention to a dorsolateral region of the suprachiasmatic nucleus and the medial division of the lateral habenula, Mahboubeh Tavakoli-Nezhad and William J. Schwartz

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Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis, Ashutosh Tiwari, Zuoshang Xu, and Lawrence J. Hayward

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Inhibition of chaperone activity is a shared property of several Cu,Zn-superoxide dismutase mutants that cause amyotrophic lateral sclerosis, Hemachand Tummala, Chelowha Jung, Ashutosh Tiwari, Cynthia M. J. Higgins, Lawrence J. Hayward, and Zuoshang Xu

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Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy, Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, Ralph L. Sacco, and Marc Fisher

Publications from 2004

The aging factor in health and disease: the promise of basic research on aging, Robert N. Butler, Huber R. Warner, T. Franklin Williams, Steven N. Austad, Jacob A. Brody, Judith Campisi, Anthony Cerami, Gene D. Cohen, Vincent J. Cristofalo, David A. Drachman, Caleb E. Finch, Irwin Fridovich, Calvin B. Harley, Richard J. Havlik, George M. Martin, Richard A. Miller, S. Jay Olshansky, Olivia M. Pereira-Smith, James R. Smith, Richard L. Sprott, Michael D. West, John R. Wilmoth, and Woodring E. Wright

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Structural basis of heteromeric smad protein assembly in TGF-beta signaling, Benoy Maramparambil Chacko, Bin Y. Qin, Ashutosh Tiwari, Genbin Shi, Suvana S. Lam, Lawrence J. Hayward, Mark De Caestecker, and Kai Lin

Fading Minds and Hanging Chads: Alzheimer’s Disease and the Right to Vote, David A. Drachman

Statins in the Prevention and Treatment of Alzheimer’s Disease, David A. Drachman

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Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke, Timothy Q. Duong and Marc Fisher

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Emerging therapies for cerebrovascular disorders, Marc Fisher and Antonio Davalos