This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Neurology.

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Publications from 2007

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Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model, Romolo Joseph Gaspari and David Paydarfar

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Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats, Nils Henninger, James P. Bouley, Julia M. Nelligan, Kenneth M. Sicard, and Marc Fisher

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Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke, Nils Henninger and Marc Fisher

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Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats, Nils Henninger, Kenneth M. Sicard, and Marc Fisher

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Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat, Nils Henninger, Kenneth M. Sicard, Zhixin Li, Praveen P. Kulkarni, Stephan Dutzmann, Christian Urbanek, Stefan Schwab, and Marc Fisher

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Statins differentially affect amyloid precursor protein metabolism in presymptomatic PS1 and non-PS1 subjects, Douglas A. Hinerfeld, Majaz Moonis, Joan M. Swearer, Stephen P. Baker, Richard J. Caselli, Ekaterina Rogaeva, Peter St. George-Hyslop, and Daniel A. Pollen

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Design principles for phase-splitting behaviour of coupled cellular oscillators: clues from hamsters with 'split' circadian rhythms, Premananda Indic, William J. Schwartz, and David Paydarfar

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Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1), Yair Lampl, Justin A. Zivin, Marc Fisher, Robert A. Lew, Lennart Welin, Bjorn Dahlof, Peter Borenstein, Bjorn Andersson, Julio Perez, Cesar Caparo, Sanja Ilic, and Uri Oron

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Tracking the seasons: the internal calendars of vertebrates, Matthew J. Paul, Irving Zucker, and William J. Schwartz

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Normal breast stem cells, malignant breast stem cells, and the perinatal origin of breast cancer, Todd M. Savarese, Hoi Pang Low, Inkyung Baik, William C. Strohsnitter, and Chung-Cheng Hsieh

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Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis, Todd M. Savarese, William C. Strohsnitter, Hoi Pang Low, Qin Liu, Inkyung Baik, William C. Okulicz, David P. Chelmow, Pagona Lagiou, Peter J. Quesenberry, Kenneth L. Noller, and Chung-Cheng Hsieh

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials, Sean I. Savitz and Marc Fisher

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Prophylactic neuroprotection, Sean I. Savitz and Marc Fisher

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Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials, Sean I. Savitz, Robert A. Lew, Erich Bluhmki, Werner Hacke, and Marc Fisher

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Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia, Giles D. J. Watts, Dana Thomasova, Sheena K. Ramdeen, Erin C. Fulchiero, Sarju G. Mehta, David A. Drachman, Conrad C. Weihl, Zygmunt Jamrozik, Hubert Kwiecinski, Anna Kaminska, and Virginia E. Kimonis

Publications from 2006

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Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging, James P. Bouley, Marc Fisher, and Nils Henninger

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Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases, Suhayl Dhib-Jalbut, Douglas L. Arnold, Don W. Cleveland, Marc Fisher, Robert M. Friedlander, M. Maral Mouradian, Serge Przedborski, Bruce D. Trapp, Tony Wyss-Coray, and V. Wee Yong

Aging of the brain, entropy, and Alzheimer disease, David A. Drachman

Robert Katzman and Alzheimer's disease: an appreciation, David A. Drachman

Approaches to Cerebrovascular Disease, Marc Fisher

Identification and Treatment of Stroke Risk Factors, Marc Fisher

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NXY-059 for acute ischemic stroke: the promise of neuroprotection is finally realized, Marc Fisher

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Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist, Marc Fisher

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The ischemic penumbra: a new opportunity for neuroprotection, Marc Fisher

Imaging in Experimental Neurology, Marc Fisher, Eng H. Lo, and Michael Lev

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Handbook of Experimental Neurology: Methods and Techniques in Animal Research, Marc Fisher and Turgut Tatlisumak

Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations, Mark S. Forman, Ian R. Mackenzie, Nigel J. Cairns, Eric Swanson, Philip J. Boyer, David A. Drachman, Bharati S. Jhaveri, Jason H. Karlawish, Alan Pestronk, Thomas W. Smith, Pang-Hsien Tu, Giles D. J. Watts, William R. Markesbery, Charles D. Smith, and Virginia E. Kimonis

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A new model of thromboembolic stroke in the posterior circulation of the rat, Nils Henninger, Karl H. Eberius, Kenneth M. Sicard, Rainer Kollmar, Clemens Sommer, Stefan Schwab, and Wolf-Rudiger Schabitz

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Neuroprotective effect of hyperbaric oxygen therapy monitored by MR-imaging after embolic stroke in rats, Nils Henninger, Lea Kuppers-Tiedt, Kenneth M. Sicard, Albrecht Gunther, Dietmar Schneider, and Stefan Schwab

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The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia, Nils Henninger, Kenneth M. Sicard, James P. Bouley, Marc Fisher, and Nancy E. Stagliano

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Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging, Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, Juergen F. Bardutzky, and Marc Fisher

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Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea, Taichang Jang, Todd M. Savarese, Hoi Pang Low, Sunchin Kim, Hannes Vogel, David S. Lapointe, Timothy Q. Duong, N. Scott Litofsky, James M. Weimann, Alonzo H. Ross, and Lawrence D. Recht

The optic nerve: a window into diseases of the brain, Neil R. Miller and David A. Drachman

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Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke, Vasantha Padma, Marc Fisher, and Majaz Moonis

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Noisy inputs and the induction of on-off switching behavior in a neuronal pacemaker, David Paydarfar, Daniel B. Forger, and John R. Clay

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Perspectives on neuroprotective stroke therapy, Wolf-Rudiger Schabitz and Marc Fisher

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Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats, Kenneth M. Sicard, Nils Henninger, Marc Fisher, Timothy Q. Duong, and Craig F. Ferris

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Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats, Kenneth M. Sicard, Nils Henninger, Marc Fisher, Timothy Q. Duong, and Craig F. Ferris

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Experimental stroke: ischaemic lesion volume and oedema formation differ among rat strains (a comparison between Wistar and Sprague-Dawley rats using MRI), Maureen Walberer, Erwin Stolz, Clemens Muller, C. Friedrich, Carina Rottger, F. Blaes, Manfred Kaps, Marc Fisher, Georg Bachmann, and Tibo Gerriets

Publications from 2005

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Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model, Juergen F. Bardutzky, Xiangjun Meng, James P. Bouley, Timothy Q. Duong, Rajiv Ratan, and Marc Fisher

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Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution, Juergen F. Bardutzky, Qiang Shen, James P. Bouley, Christopher H. Sotak, Timothy Q. Duong, and Marc Fisher

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Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging, Juergen F. Bardutzky, Qiang Shen, Nils Henninger, James P. Bouley, Timothy Q. Duong, and Marc Fisher

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Development and validation of the stroke action test, Susan Billings-Gagliardi and Kathleen M. Mazor

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Emerging therapies for cerebrovascular disorders, Antonio Davalos and Marc Fisher

Commentary on “Diagnosis of Alzheimer’s disease: Two decades of progress.” Alzheimer’s Disease: Years of Progress, and an Army of Researchers Recruited; AD Remains an Elusive Adversary, David A. Drachman

Do we have brain to spare, David A. Drachman

Analysis of Acute Perihematomal Edema in Warfarin-Related Intracerebral Hemorrhage, David Finkelstein

Developing and implementing future stroke therapies: the potential of telemedicine, Marc Fisher

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Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable, Marc Fisher, Gregory W. Albers, Geoffrey A. Donnan, Anthony J. Furlan, James Grotta, Chelsea S. Kidwell, Ralph L. Sacco, and Lawrence R. Wechsler

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Use of animal models has not contributed to development of acute stroke therapies: con, Marc Fisher and Turgut Tatlisumak

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Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke, Anthony J. Furlan and Marc Fisher

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Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging, Erica C. Henning, Xiangjun Meng, Marc Fisher, and Christopher H. Sotak

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Impaired spatial learning in a novel rat model of mild cerebral concussion injury, Nils Henninger, Stephan Dutzmann, Kenneth M. Sicard, Rainer Kollmar, Juergen F. Bardutzky, and Stefan Schwab

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome, Majaz Moonis, Kevin J. Kane, Ute Schwiderski, Bobby W. Sandage, and Marc Fisher

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Myelination and long diffusion times alter diffusion-tensor-imaging contrast in myelin-deficient shiverer mice, Govind Nair, Yusuke Tanahashi, Hoi Pang Low, Susan Billings-Gagliardi, William J. Schwartz, and Timothy Q. Duong

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Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics, Philip M. Newton, Keith Tully, Thomas McMahon, Jackie Connolly, Jahan Dadgar, Steven N. Treistman, and Robert O. Messing

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Thrombolytic therapy for acute ischemic stroke: 3 h and beyond, Vasantha Padma, Marc Fisher, and Majaz Moonis

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Isolation of immortalized, INK4a/ARF-deficient cells from the subventricular zone after in utero N-ethyl-N-nitrosourea exposure, Todd M. Savarese, Taichang Jang, Hoi Pang Low, Rebecca Salmonsen, N. Scott Litofsky, Zdenka Matijasevic, Alonzo H. Ross, and Lawrence D. Recht

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Functional, perfusion and diffusion MRI of acute focal ischemic brain injury, Qiang Shen, Hongxia Ren, Haiying Cheng, Marc Fisher, and Timothy Q. Duong

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Statistical prediction of tissue fate in acute ischemic brain injury, Qiang Shen, Hongxia Ren, Marc Fisher, and Timothy Q. Duong

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c-Fos expression in the brains of behaviorally "split" hamsters in constant light: calling attention to a dorsolateral region of the suprachiasmatic nucleus and the medial division of the lateral habenula, Mahboubeh Tavakoli-Nezhad and William J. Schwartz

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Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis, Ashutosh Tiwari, Zuoshang Xu, and Lawrence J. Hayward

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Inhibition of chaperone activity is a shared property of several Cu,Zn-superoxide dismutase mutants that cause amyotrophic lateral sclerosis, Hemachand Tummala, Chelowha Jung, Ashutosh Tiwari, Cynthia M. J. Higgins, Lawrence J. Hayward, and Zuoshang Xu

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Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy, Steven Warach, David Kaufman, David Chiu, Thomas Devlin, Marie Luby, Ajaz Rashid, Linda Clayton, Markku Kaste, Kennedy R. Lees, Ralph L. Sacco, and Marc Fisher

Publications from 2004

The aging factor in health and disease: the promise of basic research on aging, Robert N. Butler, Huber R. Warner, T. Franklin Williams, Steven N. Austad, Jacob A. Brody, Judith Campisi, Anthony Cerami, Gene D. Cohen, Vincent J. Cristofalo, David A. Drachman, Caleb E. Finch, Irwin Fridovich, Calvin B. Harley, Richard J. Havlik, George M. Martin, Richard A. Miller, S. Jay Olshansky, Olivia M. Pereira-Smith, James R. Smith, Richard L. Sprott, Michael D. West, John R. Wilmoth, and Woodring E. Wright

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Structural basis of heteromeric smad protein assembly in TGF-beta signaling, Benoy Maramparambil Chacko, Bin Y. Qin, Ashutosh Tiwari, Genbin Shi, Suvana S. Lam, Lawrence J. Hayward, Mark De Caestecker, and Kai Lin

Fading Minds and Hanging Chads: Alzheimer’s Disease and the Right to Vote, David A. Drachman

Statins in the Prevention and Treatment of Alzheimer’s Disease, David A. Drachman

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Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke, Timothy Q. Duong and Marc Fisher

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Emerging therapies for cerebrovascular disorders, Marc Fisher and Antonio Davalos

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The MATCH study results in the context of secondary stroke prevention, Marc Fisher and Antonio Davalos

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Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging, Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, A. Bachmann, Marc Fisher, Manfred Kaps, and Georg Bachmann

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Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats, Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Alexander Kluge, Manfred Kaps, Marc Fisher, and Georg Bachmann

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Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography, Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Muller, Carina Rottger, Alexander Kluge, Manfred Kaps, Marc Fisher, and Georg Bachmann

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Differentiation prevents assessment of neural stem cell pluripotency after blastocyst injection, Beatrice Greco, Hoi Pang Low, Eric C. Johnson, Rebecca Salmonsen, Judith Gallant, Stephen N. Jones, Alonzo H. Ross, and Lawrence D. Recht

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Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats, Mark Kazemi, Matthew D. Silva, Fuhai Li, Marc Fisher, and Christopher H. Sotak

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Microsphere-induced embolic stroke: an MRI study, Orna Mayzel-Oreg, Tsuyoshi Omae, Mark Kazemi, Fuhai Li, Marc Fisher, Yoram Cohen, and Christopher H. Sotak

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Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia, Xiangjun Meng, Marc Fisher, Qiang Shen, Christopher H. Sotak, and Timothy Q. Duong

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Antiplatelet treatment for secondary prevention of acute ischemic stroke and transient ischemic attacks: mechanisms, choices and possible emerging patterns of use, Majaz Moonis and Marc Fisher

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Antihypertensive medications for risk reduction of first and recurrent ischemic stroke, Vasantha Padma, Marc Fisher, and Majaz Moonis

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Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model, Hongxia Ren, Qiang Shen, Juergen F. Bardutzky, Marc Fisher, and Timothy Q. Duong

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Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging, Qiang Shen, Marc Fisher, Christopher H. Sotak, and Timothy Q. Duong

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Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data, Qiang Shen, Hongxia Ren, Marc Fisher, James P. Bouley, and Timothy Q. Duong

Publications from 2003

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Lateralization of circadian pacemaker output: Activation of left- and right-sided luteinizing hormone-releasing hormone neurons involves a neural rather than a humoral pathway, Horacio O. de la Iglesia, Jennifer Meyer, and William J. Schwartz

Preventing and treating Alzheimer’s disease: strategies and prospects, David A. Drachman

Imaging as a Surrogate Marker in Clinical Trials, Marc Fisher

Ongoing trials and future directions for acute ischemic stroke treatment, Marc Fisher

Ongoing Trials and Future Directions for Acute Ischemic Stroke Treatment, Marc Fisher

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Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3, Marc Fisher

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Stem cell transplantation for stroke: does it work, and if so, how, Marc Fisher

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The ischemic penumbra: identification, evolution and treatment concepts, Marc Fisher

Using Diffusion-Perfusion MRI in Animal Models for Drug Development, Marc Fisher

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Emerging therapies for acute ischemic stroke: new therapies on trial, Marc Fisher and Thomas G. Brott

Magnetic Resonance Imaging in Stroke, Marc Fisher, Stephen Davis, and Steven Warach

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Combination Therapies, Restorative Therapies and Future Directions, Marc Fisher and Majaz Moonis

Neurovascular Disorders, Marc Fisher, E. Orberk, and M. Ramzan

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New perspectives on developing acute stroke therapy, Marc Fisher and Rajiv Ratan

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The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats, Tibo Gerriets, Fuhai Li, Matthew D. Silva, Xiangjun Meng, Mathew E. Brevard, Christopher H. Sotak, and Marc Fisher

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Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance, Tibo Gerriets, Erwin Stolz, Maureen Walberer, Manfred Kaps, Georg Bachmann, and Marc Fisher

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Sensory regulation of swallowing and airway protection: a role for the internal superior laryngeal nerve in humans, Samah Jafari, Rebecca A. Prince, Daniel Y. Kim, and David Paydarfar