Title

Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model

UMMS Affiliation

Department of Neurology; Department of Radiology; Graduate School of Biomedical Sciences

Date

1-1-1995

Document Type

Article

Subjects

Animals; Brain; Brain Ischemia; Cerebral Arteries; Cerebrovascular Disorders; Disease Models, Animal; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley; Time Factors

Disciplines

Nervous System Diseases | Neurology | Radiology

Abstract

Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset of ischemia. The use of a DWI echo-planar multislice technique in this study and the mapping of the apparent diffusion coefficient (ADC) of water, a reliable indicator of ischemic regions, allow for the detection of the three-dimensional (3-D) evolution of ischemia in a rat stroke model. We evaluated 13 time points from 5 to 180 minutes after occlusion of the middle cerebral artery (MCA) and monitored the 3-D spread of ischemia. Within 5 minutes after the onset of ischemia, regions with reduced ADC values occurred. The core of the lesion, with the lowest absolute ADC values, first appeared in the lateral caudoputamen and frontoparietal cortex, then spread to adjacent areas. The volume of ischemic tissue was 224 +/- 48.5 mm3 (mean +/- SEM) after 180 minutes, ranging from 92 to 320 mm3, and this correlated well with the corrected infarct volume at postmortem (194 +/- 23.1 mm3, r = 0.72, p < 0.05). This experiment demonstrated that 3-D multislice diffusion mapping can detect ischemic regions noninvasively 5 minutes after MCA occlusion and follow the development of ischemia. The distribution of changes in absolute ADC values within the ischemic region can be followed over time, giving important information about the evolution of focal ischemia.

Rights and Permissions

Citation: Neurology. 1995 Jan;45(1):172-7.

Related Resources

Link to article in PubMed

PubMed ID

7824111