Title

A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls

UMMS Affiliation

Department of Neurology

Date

2-1991

Document Type

Article

Subjects

Adult; Dose-Response Relationship, Drug; Female; Humans; Hydrogen Peroxide; Luminescent Measurements; Male; Middle Aged; Monocytes; Multiple Sclerosis; Osmolar Concentration; Pregnatrienes; Reference Values

Disciplines

Nervous System Diseases | Neurology

Abstract

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local tissue injury by generating an inflammatory response, mediated in part by the production of toxic oxygen metabolites. Corticosteroids are frequently and effectively used to ameliorate MS exacerbations, despite inadequate knowledge about the mechanism. We assessed the effects of a 21-aminosteroid, U74500A, a new class of steroid derivatives without glucocorticoid or mineralocorticoid effects, on the production of hydrogen peroxide (H2O2) and chemiluminescence by stimulated monocytes harvested from 8 stable MS patients and age- and sex-matched controls. H2O2 measurements and chemiluminescence were significantly reduced in both groups by U74500A. These results demonstrate that 21-aminosteroids reduce production of toxic oxygen metabolites by monocytes and thus their inflammatory potential, suggesting that these agents may be potentially effective and safe treatment for MS exacerbations.

Rights and Permissions

Citation: Neurology. 1991 Feb;41(2 ( Pt 1)):297-9.

Related Resources

Link to article in PubMed

PubMed ID

1992380