Title

Good laboratory practice: preventing introduction of bias at the bench

UMMS Affiliation

Department of Neurology

Date

8-16-2008

Document Type

Article

Subjects

Animals; *Bias (Epidemiology); Conflict of Interest; Disease Models, Animal; Drug Industry; Humans; Random Allocation; Research Design; Research Support as Topic; Sample Size; Stroke; Treatment Outcome

Disciplines

Neurology | Neuroscience and Neurobiology

Abstract

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review- Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.

CONCLUSIONS: Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.

Rights and Permissions

Citation: Stroke. 2009 Mar;40(3):e50-2. Epub 2008 Aug 14. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

18703798