Title

Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium

UMMS Affiliation

Department of Medicine; Department of Neurology; Brudnick Neuropsychiatric Research Institute

Date

7-1-1994

Document Type

Article

Subjects

Aged; Alleles; Alzheimer Disease; Apolipoprotein C-II; Apolipoproteins C; Apolipoproteins E; Female; Gene Frequency; Humans; Jews; *Linkage Disequilibrium; Male; *Polymorphism, Genetic

Disciplines

Neurology | Neuroscience and Neurobiology

Abstract

Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with epsilon 4 is probably not due to linkage disequilibrium.

Rights and Permissions

Citation: Ann Neurol. 1994 Jul;36(1):97-100. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

8024269

This document is currently not available here.

Share

COinS