Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium
Department of Medicine; Department of Neurology; Brudnick Neuropsychiatric Research Institute
Aged; Alleles; Alzheimer Disease; Apolipoprotein C-II; Apolipoproteins C; Apolipoproteins E; Female; Gene Frequency; Humans; Jews; *Linkage Disequilibrium; Male; *Polymorphism, Genetic
Neurology | Neuroscience and Neurobiology
Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with epsilon 4 is probably not due to linkage disequilibrium.
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Citation: Ann Neurol. 1994 Jul;36(1):97-100. Link to article on publisher's site
Tsuda, Takehide; Lopez-Alberola, Robert F.; Rogaeva, Evgeny A.; Freedman, Morris; Rogaev, Evgeny I.; Drachman, David A.; Pollen, Daniel A.; Haines, Jonathan L.; Liang, Y.; and McLachlan, Donald R., "Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium" (1994). Neurology Publications and Presentations. Paper 295.
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