Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium
Authors
Tsuda, TakehideLopez-Alberola, Robert F.
Rogaeva, Evgeny A.
Freedman, Morris
Rogaev, Evgeny I.
Drachman, David A.
Pollen, Daniel A.
Haines, Jonathan L.
Liang, Y.
McLachlan, Donald R.
UMass Chan Affiliations
Brudnick Neuropsychiatric Research InstituteDepartment of Neurology
Department of Medicine
Document Type
Journal ArticlePublication Date
1994-07-01Keywords
AgedAlleles
Alzheimer Disease
Apolipoprotein C-II
Apolipoproteins C
Apolipoproteins E
Female
Gene Frequency
Humans
Jews
*Linkage Disequilibrium
Male
*Polymorphism, Genetic
Neurology
Neuroscience and Neurobiology
Metadata
Show full item recordAbstract
Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with epsilon 4 is probably not due to linkage disequilibrium.Source
Tsuda T, Lopez R, Rogaeva EA, Freedman M, Rogaev E, Drachman D, Pollen D, Haines J, Liang Y, McLachlan DR, et al. Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium? Ann Neurol. 1994 Jul;36(1):97-100. doi: 10.1002/ana.410360118. PMID: 8024269. Link to article on publisher's site
DOI
10.1002/ana.410360118Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37673PubMed ID
8024269Related Resources
ae974a485f413a2113503eed53cd6c53
10.1002/ana.410360118
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