Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging
UMass Chan Affiliations
Graduate School of Biomedical SciencesDepartment of Radiology
Department of Neurology
Document Type
Journal ArticlePublication Date
2005-03-31Keywords
AnimalsImage Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Manganese
Potassium Chloride
Rats
Rats, Sprague-Dawley
Reproducibility of Results
*Spreading Cortical Depression
Neurology
Radiology
Metadata
Show full item recordAbstract
Cortical spreading depression (CSD) was visualized using manganese-enhanced MRI (MEMRI) following topical application of KCl to the exposed rat cortex. MEMRI signal increase in the ipsilateral cortex relative to the contralateral control region was 60 +/- 30% following two KCl applications. MEMRI signal increase for a single (40%) versus double (80%) KCl application suggests an integration effect over successive CSD episodes. CSD-induced MEMRI enhancement involved cortical layers containing dense regions of apical dendrites, supporting the contention that these neuronal structures are necessary for propagation of CSDs. Subcortical enhancement was present in hippocampal and thalamic regions, most likely a result of neuronal connections with cortical layers 4 and 5. These results are consistent with previous studies of CSD using diffusion-weighted MRI and T(2) (*)-weighted MRI and should be useful for investigating CSD itself and its role in other neurologic disorders.Source
Magn Reson Med. 2005 Apr;53(4):851-7. Link to article on publisher's siteDOI
10.1002/mrm.20438Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37632PubMed ID
15799040Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/mrm.20438