Title

Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain

UMMS Affiliation

Department of Neurology; Department of Radiology; Graduate School of Biomedical Sciences

Date

3-1995

Document Type

Article

Subjects

Animals; Brain; Brain Ischemia; Diffusion; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley; *Spreading Cortical Depression; Water

Disciplines

Neurology | Radiology

Abstract

Using echo planar diffusion-weighted magnetic resonance imaging, we measured three-dimensional changes in the apparent diffusion coefficient (ADC) of water in eight contiguous coronal slices, encompassing the entire rat brain, before and after local cortical stimulation. We applied chemical (potassium chloride application; n = 6) and mechanical (needle stab; n = 4) stimulations to the right posterior parietal rat cortex. In all animals in which potassium chloride or the needle stab was applied, a region of decreased ADC values to a mean of 0.45 +/- 0.03 x 10(-5)cm2/s occurred. These reduced ADC levels appeared in the posterior parietal cortex within 1 min after cortical stimulation and the change recovered within 1 min. Then a ripple-like movement of similar changes developed across the unilateral cortex. This change was localized to the cortex and no significant ADC changes occurred in subcortical structures. The propagating speed of this movement was 3.4 +/- 0.5 mm/min. These findings are compatible with spreading depression as observed electrophysiologically. Similar ADC changes occurred in areas distinct from the ischemic lesion in 3 of 12 animals subjected to focal cerebral ischemia. This magnetic resonance method could detect spreading ADC decline if it occurred in human diseases including brain ischemia.

Rights and Permissions

Citation: J Cereb Blood Flow Metab. 1995 Mar;15(2):179-87.

Related Resources

Link to article in PubMed

PubMed ID

7860651