Understanding signal transduction during bacterial infection
Department of Molecular Genetics and Microbiology
Medical Subject Headings
Animals; Bacterial Proteins; Bordetella Infections; Gene Expression Regulation, Bacterial; Humans; *Signal Transduction; Transcription Factors
Microbiology | Molecular genetics
Many known or suspected bacterial virulence factors require environmentally responsive control factors for expression. In Bordetella species, the BvgAS system represses and activates sets of genes, and mediates a biphasic phenotypic transition. Studies using mutants with altered signaling pathways and reversed regulatory connections have provided insights into the role of BvgAS and this phenotypic transition during the Bordetella-host interaction.
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Citation: Trends Microbiol. 1996 Apr;4(4):141-6.