Title

Understanding signal transduction during bacterial infection

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Date

4-1-1996

Document Type

Article

Medical Subject Headings

Animals; Bacterial Proteins; Bordetella Infections; Gene Expression Regulation, Bacterial; Humans; *Signal Transduction; Transcription Factors

Disciplines

Microbiology | Molecular genetics

Abstract

Many known or suspected bacterial virulence factors require environmentally responsive control factors for expression. In Bordetella species, the BvgAS system represses and activates sets of genes, and mediates a biphasic phenotypic transition. Studies using mutants with altered signaling pathways and reversed regulatory connections have provided insights into the role of BvgAS and this phenotypic transition during the Bordetella-host interaction.

Rights and Permissions

Citation: Trends Microbiol. 1996 Apr;4(4):141-6.

Related Resources

Link to Article in PubMed