Title
Understanding signal transduction during bacterial infection
UMMS Affiliation
Department of Molecular Genetics and Microbiology
Date
4-1-1996
Document Type
Article
Medical Subject Headings
Animals; Bacterial Proteins; Bordetella Infections; Gene Expression Regulation, Bacterial; Humans; *Signal Transduction; Transcription Factors
Disciplines
Microbiology | Molecular genetics
Abstract
Many known or suspected bacterial virulence factors require environmentally responsive control factors for expression. In Bordetella species, the BvgAS system represses and activates sets of genes, and mediates a biphasic phenotypic transition. Studies using mutants with altered signaling pathways and reversed regulatory connections have provided insights into the role of BvgAS and this phenotypic transition during the Bordetella-host interaction.
Rights and Permissions
Citation: Trends Microbiol. 1996 Apr;4(4):141-6.