This collection showcases the journal articles and other publications authored by faculty and researchers in the Department of Molecular Genetics and Microbiology prior to the department becoming part of the Department of Microbiology and Physiological Systems in 2010. For recent articles see the Microbiology and Physiological Systems Publications and Presentations collection.

Follow

Publications from 2012

Link

The NLRP12 Inflammasome Recognizes Yersinia pestis, Gregory I. Vladimer, Dan Weng, Sara W. Montminy Paquette, Sivapriya Kailasan Vanaja, Vijay A.K. Rathinam, Marie Hjelmseth Aune, Joseph E. Conlon, Joseph J. Burbage, Megan K. Proulx, Qin Liu, George W. Reed, Joan C. Mecsas, Yoichiro Iwakura, John Bertin, Jon D. Goguen, Katherine A. Fitzgerald, and Egil Lien

Publications from 2011

Link

High-throughput insertion tracking by deep sequencing for the analysis of bacterial pathogens, Sandy M. S. Wong, Jeffrey D. Gawronski, David S. Lapointe, and Brian J. Akerley

PDF

MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression, Jun Xie, Qing Xie, Hongwei Zhang, Stefan L. Ameres, Jui-Hung Hung, Qin Su, Ran He, Xin Mu, Seemin Seher Ahmed, Soyeon Park, Hiroki Kato, Chengjian Li, Christian Mueller, Craig C. Mello, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

Link

Listeria monocytogenes infection induces prosurvival metabolic signaling in macrophages, Tie Zou, Oleg Garifulin, Robert Berland, and Victor L. Boyartchuk

Publications from 2010

PDF

Degradation of YRA1 Pre-mRNA in the Cytoplasm Requires Translational Repression, Multiple Modular Intronic Elements, Edc3p, and Mex67p, Shuyun Dong, Allan Jacobson, and Feng He

Link

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses, Vijay A.K. Rathinam, Zhaozhao Jiang, Stephen N. Waggoner, Shrutie Sharma, Leah E. Cole, Lisa Waggoner, Sivapriya Kailasan Vanaja, Brian G. Monks, Sandhya Ganesan, Eicke Latz, Veit Hornung, Stefanie N. Vogel, Eva Szomolanyi-Tsuda, and Katherine A. Fitzgerald

PDF

The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe, Samriddha Ray, Kazunori Kume, Sneha Gupta, Wanzhong Ge, Mohan Balasubramanian, Dai Hirata, and Dannel McCollum

PDF

Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies, Kathryn H. Richards, Marlen M.I. Aasa-Chapman, Aine McKnight, and Paul R. Clapham

PDF

Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation, Didier F. Vingadassalom, Kenneth Geno Campellone, Michael John Brady, Brian M. Skehan, Scott E. Battle, Douglas Robbins, Archana Kapoor, Gail Hecht, Scott B. Snapper, and John M. Leong

Publications from 2009

Link

Phosphorylation state defines discrete roles for monopolin in chromosome attachment and spindle elongation., Sung Hugh Choi, Marie-Pierre Péli-Gulli, Iain Mcleod, Ali Sarkeshik, John R. Yates III, Viesturs Simanis, and Dannel McCollum

PDF

Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung, Jeffrey D. Gawronski, Sandy M. S. Wong, Georgia Giannoukos, Doyle V. Ward, and Brian J. Akerley

Link

Response to Comment on "Reassessment of the Role of Mut S Homolog 5 in Ig Class Switch Recombination Shows Lack of Involvement in cis- and trans-Switching", Jeroen E. J. Guikema, Carol E. Schrader, Stephen Baker, Winfried Edelmann, and Janet Stavnezer

Link

Resistance of Haemophilus influenzae to reactive nitrogen donors and gamma interferon-stimulated macrophages requires the formate-dependent nitrite reductase regulator-activated ytfE gene, Jane Colleen Harrington, Sandy M. S. Wong, Charles V. Rosadini, Oleg Garifulin, Victor L. Boyartchuk, and Brian J. Akerley

PDF

NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis, Amit K. Pandey, Yibin Yang, Zhaozhao Jiang, Sarah M. Fortune, Francois Coulombe, Marcel A. Behr, Katherine A. Fitzgerald, Christopher M. Sassetti, and Michelle A. Kelliher

Publications from 2008

Link

The periplasmic disulfide oxidoreductase DsbA contributes to Haemophilus influenzae pathogenesis, Charles V. Rosadini, Sandy M. S. Wong, and Brian J. Akerley

Link

Mechanism and regulation of class switch recombination, Janet Stavnezer, Jeroen E. J. Guikema, and Carol E. Schrader

Link

Structure of YraM, a protein essential for growth of Haemophilus influenzae, J. Vijayalakshmi, Brian J. Akerley, and Mark A. Saper

Link

Identification and analysis of essential genes in Haemophilus influenzae, Sandy M. S. Wong and Brian J. Akerley

Publications from 2007

PDF

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination, Jeroen E. J. Guikema, Erin K. Linehan, Daisuke Tsuchimoto, Yusaku Nakabeppu, Phyllis R. Strauss, Janet Stavnezer, and Carol E. Schrader

Link

Antibody class switching differs among SJL, C57BL/6 and 129 mice, Denise A. Kaminski and Janet Stavnezer

Link

Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b, Denise A. Kaminski and Janet Stavnezer

Link

The ArcA regulon and oxidative stress resistance in Haemophilus influenzae, Sandy M. S. Wong, Kishore R. Alugupalli, Sanjay Ram, and Brian J. Akerley

Link

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination, Xiaoming Wu and Janet Stavnezer

Publications from 2006

Link

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA, Sean P. Bradley, Denise A. Kaminski, Antoine H. F. M. Peters, Thomas Jenuwein, and Janet Stavnezer

Link

Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells, Denise A. Kaminski and Janet Stavnezer

Link

Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination, Janet Stavnezer and Carol E. Schrader

Publications from 2005

Link

Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2, Irene M. Min, Lisa R. Rothlein, Carol E. Schrader, Janet Stavnezer, and Erik Selsing

Link

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching, Seok-Rae Park, Goo-Young Seo, Ae-Jin Choi, Janet Stavnezer, and Pyeung-Hyeun Kim

Link

Inducible DNA breaks in Ig S regions are dependent on AID and UNG, Carol E. Schrader, Erin K. Linehan, Sofia N. Mochegova, Robert T. Woodland, and Janet Stavnezer

Link

Environmental and genetic regulation of the phosphorylcholine epitope of Haemophilus influenzae lipooligosaccharide, Sandy M. S. Wong and Brian J. Akerley

Publications from 2004

Link

Antibody class switching: uncoupling S region accessibility from transcription, Denise A. Kaminski and Janet Stavnezer

Link

In Silico Metabolic Model and Protein Expression of Haemophilus influenzae Strain Rd KW20 in Rich Medium, Anu Raghunathan, Nathan D. Price, Michael Y. Galperin, Kira S. Makarova, Samuel Purvine, Alex F. Picone, Tim Cherny, Tao Xie, Thomas J. Reilly, Robert S. Munson, Ryan E. Tyler, Brian J. Akerley, Arnold L. Smith, Bernhard O. Palsson, and Eugene Kolker

Link

Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions, Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, Jan H. J. Hoeijmakers, and Janet Stavnezer

Link

Evolution of isotype switching, Janet Stavnezer and Chris T. Amemiya

Publications from 2003

Link

Position-based scanning for comparative genomics and identification of genetic islands in Haemophilus influenzae type b, Nicholas H. Bergman and Brian J. Akerley

Link

H. influenzae Consortium: integrative study of H. influenzae-human interactions, Eugene Kolker, Samuel Purvine, Alex F. Picone, Tim Cherny, Brian J. Akerley, Robert S. Munson, Bernhard O. Palsson, Dayle A. Daines, and Arnold L. Smith

Link

The role of human alkyladenine glycosylase in cellular resistance to the chloroethylnitrosoureas, Qiong Li, Steven E. Wright, Zdenka Matijasevic, Wincha Chong, David B. Ludlum, and Michael R. Volkert

Link

The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2, Irene M. Min, Carol E. Schrader, Joycelyn Vardo, Thomas M. Luby, Nicole D'Avirro, Janet Stavnezer, and Erik Selsing

Link

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination, Carol E. Schrader, Sean P. Bradley, Joycelyn Vardo, Sofia N. Mochegova, Erin Flanagan, and Janet Stavnezer

Link

Mlh1 can function in antibody class switch recombination independently of Msh2, Carol E. Schrader, Joycelyn Vardo, and Janet Stavnezer

Link

Inducible expression system and marker-linked mutagenesis approach for functional genomics of Haemophilus influenzae, Sandy M. S. Wong and Brian J. Akerley

Publications from 2002

Link

Analysis of gene function in bacterial pathogens by GAMBIT, Brian J. Akerley and David J. Lampe

Link

A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae, Brian J. Akerley, Eric J. Rubin, Veronica N. Novik, Kensey Amaya, Nicholas Judson, and John J. Mekalanos

Link

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA, Elise E. Drouin, Carol E. Schrader, Janet Stavnezer, and Ulla Hansen

PDF

E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis, Harry A. Rogoff, Mary Theresa Pickering, Michelle E. Debatis, Stephen N. Jones, and Timothy F. Kowalik

Link

Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions, Carol E. Schrader, Joycelyn Vardo, and Janet Stavnezer

Link

Does activation-induced deaminase initiate antibody diversification by DNA deamination, Janet Stavnezer and Sean P. Bradley

Link

Immunoglobulin genes: generating diversity with AID and UNG, Ursula Storb and Janet Stavnezer

Publications from 2001

Link

Redox signal transduction by the ArcB sensor kinase of Haemophilus influenzae lacking the PAS domain, Dimitris Georgellis, Ohsuk Kwon, Edmund C. Lin, Sandy M. S. Wong, and Brian J. Akerley

Link

Transposon mutagenesis of Campylobacter jejuni identifies a bipartite energy taxis system required for motility, David R. Hendrixson, Brian J. Akerley, and Victor J. DiRita

Link

The mu switch region tandem repeats are important, but not required, for antibody class switch recombination, Thomas M. Luby, Carol E. Schrader, Janet Stavnezer, and Erik Selsing

Link

Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40, C. S. Mao and Janet Stavnezer

Link

Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors, Ching-Hung Shen and Janet Stavnezer

Link

Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1, M. J. Shi, S. R. Park, P. H. Kim, and Janet Stavnezer

Publications from 2000

Regulation of the promoter for human immunoglobulin gamma3 germ-line transcription and its interaction with the 3'alpha enhancer, Q. Pan, C. Petit-Frere, Janet Stavnezer, and L. Hammarstrom

Link

Evidence for class-specific factors in immunoglobulin isotype switching, A. Shanmugam, M. J. Shi, L. Yauch, Janet Stavnezer, and A. L. Kenter

Link

Immunology. A touch of antibody class, Janet Stavnezer

Molecular processes that regulate class switching, Janet Stavnezer

Publications from 1999

Link

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter, J. Hanai, L. F. Chen, T. Kanno, N. Ohtani-Fujita, W. Y. Kim, W. H. Guo, T. Imamura, Y. Ishidou, M. Fukuchi, M. J. Shi, Janet Stavnezer, M. Kawabata, K. Miyazono, and Y. Ito

Link

Hyperactive transposase mutants of the Himar1 mariner transposon, David J. Lampe, Brian J. Akerley, Eric J. Rubin, John J. Mekalanos, and Hugh M. Robertson

Link

Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice, G. Qiu, G. R. Harriman, and Janet Stavnezer

PDF

Cytoplasmic polyadenylation in development and beyond, Joel D. Richter

Link

In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria, Eric J. Rubin, Brian J. Akerley, Veronica N. Novik, David J. Lampe, Robert N. Husson, and John J. Mekalanos

Link

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes, Carol E. Schrader, Winifred Edelmann, R. Kucherlapati, and Janet Stavnezer

Link

Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes, Janet Stavnezer, Sean P. Bradley, Norman Rousseau, Todd Pearson, Ananth Shanmugam, Debra J. Waite, Paul R. Rogers, and Amy L. Kenter

Publications from 1998

Link

Systematic identification of essential genes by in vitro mariner mutagenesis, Brian J. Akerley, Eric J. Rubin, Andrew Camilli, David J. Lampe, Hugh M. Robertson, and John J. Mekalanos

Link

Filamentous hemagglutinin of Bordetella bronchiseptica is required for efficient establishment of tracheal colonization, Peggy A. Cotter, Ming H. Yuk, Seema Mattoo, Brian J. Akerley, Jeff Boschwitz, David A. Relman, and Jeff F. Miller

Link

The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins, S. C. Lin, H. H. Wortis, and Janet Stavnezer

Link

Neither the Bvg- phase nor the vrg6 locus of Bordetella pertussis is required for respiratory infection in mice, Guillermo Martinez de Tejada, Peggy A. Cotter, Ulrich Heininger, Andrew Camilli, Brian J. Akerley, John J. Mekalanos, and Jeff F. Miller

Link

Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line, G. Qiu and Janet Stavnezer

Link

Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription, Ching-Hung Shen and Janet Stavnezer

Link

CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter, M. J. Shi and Janet Stavnezer

Publications from 1997

Link

CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction, L. A. Iciek, S. A. Delphin, and Janet Stavnezer

Link

Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig, Carol E. Schrader, Janet Stavnezer, H. Kikutani, and D. C. Parker

Publications from 1996

Link

Understanding signal transduction during bacterial infection, Brian J. Akerley and Jeff F. Miller

Link

The role of charged residues in determining transmembrane protein insertion orientation in yeast, Carol A. Harley and Donald J. Tipper

Link

Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter, S. C. Lin and Janet Stavnezer

Link

Mouse CD6: sequence of cDNA and expression of mRNA, A. Pal, Paul L. Romain, N. G. Singer, D. Fox, and Janet Stavnezer

Link

Antibody class switching, Janet Stavnezer

Link

Immunoglobulin class switching, Janet Stavnezer

Publications from 1995

Link

Ectopic expression of the flagellar regulon alters development of the Bordetella-host interaction, Brian J. Akerley, Peggy A. Cotter, and Jeff F. Miller

Link

BvgAS Dependent Phenotypic Modulation of Bordetella Species, Peggy A. Cotter, Brian J. Akerley, and Jeff F. Miller

Link

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50, S. Delphin and Janet Stavnezer

Link

Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter, S. Delphin and Janet Stavnezer

Link

bvg Repression of alcaligin synthesis in Bordetella bronchiseptica is associated with phylogenetic lineage, Peter C. Giardina, Lisa-Anne Foster, James M. Musser, Brian J. Akerley, Jeff F. Miller, and David W. Dyer

Link

Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members, M. Lundgren, L. Strom, L. O. Bergquist, S. Skog, T. Heiden, Janet Stavnezer, and E. Severinson

Link

Regulation of antibody production and class switching by TGF-beta, Janet Stavnezer

Publications from 1994

Link

Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site, M. Lundgren, C. Larsson, Andrea Femino, M. Xu, Janet Stavnezer, and E. Severinson

Publications from 1993

Link

Flagellin gene transcription in Bordetella bronchiseptica is regulated by the BvgAS virulence control system, Brian J. Akerley and Jeff F. Miller

PDF

Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant, Feng He, Stuart W. Peltz, Janet L. Donahue, Michael Rosbash, and Allan Jacobson

Link

Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching, P. Shockett and Janet Stavnezer

Publications from 1992

Link

The bvgAS locus negatively controls motility and synthesis of flagella in Bordetella bronchiseptica, Brian J. Akerley, Denise M. Monack, Stanley Falkow, and Jeff F. Miller

Regulation of switch recombination to the murine gamma 1 gene, W. Dunnick, L. Elenich, J. Berry, D. Albrecht, Janet Stavnezer, and J. L. Claflin

Regulation of transcription of the germline immunoglobulin alpha constant region gene, Y. C. Lin, P. Shockett, and Janet Stavnezer

Link

Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements, Y. C. Lin and Janet Stavnezer

Link

Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer, M. Z. Xu and Janet Stavnezer

Publications from 1991

Link

Regulation of the antibody class switch to IgA, Y. C. Lin, P. Shockett, and Janet Stavnezer

Link

Activation of MAP-2 kinase activity by the CD2 receptor in Jurkat T cells can be reversed by CD45 phosphatase, Andre E. Nel, Jeffrey A. Ledbetter, Katherine Williams, P. Ho, Brian J. Akerley, Kymberly Franklin, and Rina Katz

Link

Evidence for involvement of glycoprotein-CD45 phosphatase in reversing glycoprotein-CD3-induced microtubule-associated protein-2 kinase activity in Jurkat T-cells, Shimon Pollack, Jeffrey A. Ledbetter, Rina Katz, Katherine Williams, Brian J. Akerley, Kymberly Franklin, Gary L. Schieven, and Andre E. Nel

Link

Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene, P. Shockett and Janet Stavnezer