Heparin-induced thrombocytopenia in the pediatric population: a review of current literature
UMass Chan Affiliations
Meyers Primary Care InstituteDocument Type
Journal ArticlePublication Date
2012-01-01Keywords
ThrombocytopeniaHeparin
Child
Carbohydrates
Health Services Research
Hemic and Lymphatic Diseases
Pediatrics
Pharmacy and Pharmaceutical Sciences
Metadata
Show full item recordAbstract
Heparin-induced thrombocytopenia is a rare and serious reaction to unfractionated heparin and low-molecular-weight heparins in children. Quick recognition, discontinuation of heparin, and subsequent treatment with an alternative anticoagulant are essential steps to prevent serious complications such as thrombus and limb amputation. The purpose of this review is to describe the clinical features of heparin-induced thrombocytopenia in children and to summarize the data available for its management. This paper summarizes data and relates the use of direct thrombin inhibitors with clinical outcomes. A literature search was conducted with Ovid, using the key terms argatroban, bivalirudin, hirulog, danaparoid, lepirudin, direct thrombin inhibitor, heparin-induced thrombocytopenia, thrombosis, warfarin, and fondaparinux. Articles were excluded if they were classified as editorials, review articles, or conference abstracts or if they involved patients 18 years of age or older or described disease states not related to thrombosis. Nineteen articles containing 33 case reports were identified and evaluated for this review. Of the 33 cases, 14, 10, 4, and 2 cases described the use of lepirudin, danaparoid, argatroban, and bivalirudin, respectively. Two cases did not report the type of anticoagulant used, and 1 case used aspirin. The most commonly reported complication was bleeding.Source
J Pediatr Pharmacol Ther. 2012 Jan;17(1):12-30. doi: 10.5863/1551-6776-17.1.12. Link to article on publisher's site
DOI
10.5863/1551-6776-17.1.12Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37253PubMed ID
23118656Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.5863/1551-6776-17.1.12