Title

An overview of heparin-induced thrombocytopenia

UMMS Affiliation

Meyers Primary Care Institute

Date

6-22-2010

Document Type

Article

Medical Subject Headings

Anticoagulants; Antithrombins; Heparin; Humans; Pipecolic Acids; Thrombocytopenia; therapy; Thrombosis; Time Factors

Disciplines

Health Services Research | Primary Care

Abstract

Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse drug reaction to heparin products leading to a prothrombotic state. Devastating clinical sequelae may result, including venous or arterial thromboembolism, limb amputation, and death. Heparin cessation alone is insufficient to manage HIT. Pharmacotherapy with argatroban or lepirudin is essential. This article reviews the pathogenesis, diagnosis, and pharmacotherapy of HIT.

Rights and Permissions

Citation: J Pharm Pract. 2010 Jun;23(3):226-34. Epub 2010 Apr 13. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

21507818