Treatment of Felty's syndrome with leflunomide

UMMS Affiliation

Meyers Primary Care Institute



Document Type


Medical Subject Headings

Antirheumatic Agents; Arthritis, Rheumatoid; Felty's Syndrome; Humans; Immunosuppressive Agents; Isoxazoles; Male; Methotrexate; Middle Aged


Health Services Research | Primary Care


Felty's syndrome (FS) is a rare manifestation of severe rheumatoid arthritis (RA). It is an immune mediated inflammatory process, usually treated with standard disease modifying antirheumatic drugs. We describe a case of severe FS that developed in a patient receiving methotrexate therapy for RA. Treatment with etanercept resulted in severe allergic cutaneous reactions. The patient subsequently responded to treatment with leflunomide. The response included dramatic improvement of leukopenia and neutropenia as well as excellent control of his arthritis. Leflunomide has recently been used effectively for the treatment of RA and may be useful for the management of patients with FS.

Rights and Permissions

Citation: J Rheumatol. 2001 Apr;28(4):868-70.


At the time of publication, Nancy Walker was not yet affiliated with the University of Massachusetts Medical School.

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Link to Article in PubMed

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