Title
Treatment of Felty's syndrome with leflunomide
UMMS Affiliation
Meyers Primary Care Institute
Date
5-1-2001
Document Type
Article
Medical Subject Headings
Antirheumatic Agents; Arthritis, Rheumatoid; Felty's Syndrome; Humans; Immunosuppressive Agents; Isoxazoles; Male; Methotrexate; Middle Aged
Disciplines
Health Services Research | Primary Care
Abstract
Felty's syndrome (FS) is a rare manifestation of severe rheumatoid arthritis (RA). It is an immune mediated inflammatory process, usually treated with standard disease modifying antirheumatic drugs. We describe a case of severe FS that developed in a patient receiving methotrexate therapy for RA. Treatment with etanercept resulted in severe allergic cutaneous reactions. The patient subsequently responded to treatment with leflunomide. The response included dramatic improvement of leukopenia and neutropenia as well as excellent control of his arthritis. Leflunomide has recently been used effectively for the treatment of RA and may be useful for the management of patients with FS.
Rights and Permissions
Citation: J Rheumatol. 2001 Apr;28(4):868-70.
Comments
At the time of publication, Nancy Walker was not yet affiliated with the University of Massachusetts Medical School.