Title

Mammography surveillance and mortality in older breast cancer survivors.

UMMS Affiliation

Meyers Primary Care Institute

Date

7-20-2007

Document Type

Article

Medical Subject Headings

Age Factors; Aged; Aged, 80 and over; Breast Neoplasms; Case-Control Studies; Confidence Intervals; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Logistic Models; Mammography; Mass Screening; Needs Assessment; Neoplasm Recurrence, Local; Neoplasm Staging; Probability; Risk Assessment; SEER Program; Survival Analysis; Survivors; United States; Women's Health

Disciplines

Health Services Research | Medicine and Health Sciences

Abstract

PURPOSE: There are more than 2,000,000 breast cancer survivors in the United States today. While surveillance for asymptomatic recurrence and second primary is included in consensus recommendations, the effectiveness of this surveillance has not been well characterized. Our purpose is to estimate the effectiveness of surveillance mammography in a cohort of breast cancer survivors with complete ascertainment of surveillance mammograms and negligible losses to follow-up.

PATIENTS AND METHODS: We enrolled 1,846 stage I and II breast cancer patients who were at least 65 years old at six integrated health care delivery systems. We used medical record review and existing databases to ascertain patient, tumor, and therapy characteristics, as well as receipt of surveillance mammograms. We linked personal identifiers to the National Death Index to ascertain date and cause of death. We matched four controls to each breast cancer decedent to estimate the association between receipt of surveillance mammogram and breast cancer mortality.

RESULTS: One hundred seventy-eight women died of breast cancer during 5 years of follow-up. Each additional surveillance mammogram was associated with a 0.69-fold decrease in the odds of breast cancer mortality (95% CI, 0.52 to 0.92). The protective association was strongest among women with stage I disease, those who received mastectomy, and those in the oldest age group.

CONCLUSION: Given existing recommendations for post-therapy surveillance, trials to compare surveillance with no surveillance are unlikely. This large observational study provides support for the recommendations, suggesting that receipt of surveillance mammograms reduces the rate of breast cancer mortality in older patients diagnosed with early-stage disease.

Rights and Permissions

Citation: J Clin Oncol. 2007 Jul 20;25(21):3001-6. Epub 2007 Jun 4.

Related Resources

Link to article in PubMed

PubMed ID

17548838