Vitiligo Pathogenesis and Emerging Treatments
Department of Medicine, Division of Dermatology; UMass Metabolic Network
Cellular and Molecular Physiology | Dermatology | Skin and Connective Tissue Diseases
The pathogenesis of vitiligo involves interplay between intrinsic and extrinsic melanocyte defects, innate immune inflammation, and T-cell-mediated melanocyte destruction. The goal of treatment is to not only halt disease progression but also promote repigmentation through melanocyte regeneration, proliferation, and migration. Treatment strategies that address all aspects of disease pathogenesis and repigmentation are likely to have greatest efficacy, a strategy that may require combination therapies. Current treatments generally involve nontargeted suppression of autoimmunity, whereas emerging treatments are likely to use a more targeted approach based on in-depth understanding of disease pathogenesis, which may provide higher efficacy with a good safety profile.
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Citation: Dermatol Clin. 2017 Apr;35(2):257-265. doi: 10.1016/j.det.2016.11.014. Link to article on publisher's site
Autoimmunity, Cellular stress, Chemokines, Melanogenesis, Targeted therapy, Vitiligo
Rashighi, Medhi and Harris, John E., "Vitiligo Pathogenesis and Emerging Treatments" (2017). UMass Metabolic Network Publications. 76.