Title

The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond

UMMS Affiliation

Program in Molecular Medicine; UMass Metabolic Network

Date

5-1-2017

Document Type

Article

Disciplines

Biochemistry | Cell Biology | Cellular and Molecular Physiology | Endocrinology | Molecular Biology

Abstract

Having healthy adipose tissue is essential for metabolic fitness. This is clear from the obesity epidemic, which is unveiling a myriad of comorbidities associated with excess adipose tissue including type 2 diabetes, cardiovascular disease, and cancer. Lipodystrophy also causes insulin resistance, emphasizing the importance of having a balanced amount of fat. In cells, the mechanistic target of rapamycin (mTOR) complexes 1 and 2 (mTORC1 and mTORC2, respectively) link nutrient and hormonal signaling with metabolism, and recent studies are shedding new light on their in vivo roles in adipocytes. In this review, we discuss how recent advances in adipose tissue and mTOR biology are converging to reveal new mechanisms that maintain healthy adipose tissue, and discuss ongoing mysteries of mTOR signaling, particularly for the less understood complex mTORC2.

Rights and Permissions

Citation: Trends Endocrinol Metab. 2017 May;28(5):319-339. doi: 10.1016/j.tem.2017.01.004. Epub 2017 Feb 22. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

28237819