The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond
Program in Molecular Medicine; UMass Metabolic Network
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Endocrinology | Molecular Biology
Having healthy adipose tissue is essential for metabolic fitness. This is clear from the obesity epidemic, which is unveiling a myriad of comorbidities associated with excess adipose tissue including type 2 diabetes, cardiovascular disease, and cancer. Lipodystrophy also causes insulin resistance, emphasizing the importance of having a balanced amount of fat. In cells, the mechanistic target of rapamycin (mTOR) complexes 1 and 2 (mTORC1 and mTORC2, respectively) link nutrient and hormonal signaling with metabolism, and recent studies are shedding new light on their in vivo roles in adipocytes. In this review, we discuss how recent advances in adipose tissue and mTOR biology are converging to reveal new mechanisms that maintain healthy adipose tissue, and discuss ongoing mysteries of mTOR signaling, particularly for the less understood complex mTORC2.
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Citation: Trends Endocrinol Metab. 2017 May;28(5):319-339. doi: 10.1016/j.tem.2017.01.004. Epub 2017 Feb 22. Link to article on publisher's site
Lee, Peter L.; Jung, Su Myung; and Guertin, David A., "The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond" (2017). UMass Metabolic Network Publications. 67.