An autophagy-independent function for Beclin 1 in cancer
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network
Biochemistry | Cancer Biology | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
The involvement of Beclin 1 in cancer has been attributed primarily to its role in autophagy initiation. Our recent findings identify a novel, alternative mechanism by which Beclin 1 can impact tumor progression, through the regulation of growth factor receptor signaling.
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Citation: Mol Cell Oncol. 2016 Jan 2;3(1). pii: e1030539. Epub 2015 Apr 14. Link to article on publisher's site
autophagy, beclin 1, cancer, endocytosis, growth factor receptor, signaling
Rohatgi, Rasika and Shaw, Leslie M., "An autophagy-independent function for Beclin 1 in cancer" (2016). UMass Metabolic Network Publications. 59.