Title

Cardiometabolic disease in South Asians: A global health concern in an expanding population

UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine; UMass Metabolic Network

Date

1-1-2017

Document Type

Article

Disciplines

Biochemistry | Cardiology | Cardiovascular Diseases | Cell Biology | Cellular and Molecular Physiology | Molecular Biology

Abstract

Cardiovascular disease (CVD) is one of the main causes of mortality and morbidity worldwide. As an emerging population, South Asians (SAs) bear a disproportionately high burden of CVD relative to underlying classical risk factors, partly attributable to a greater prevalence of insulin resistance and diabetes and distinct genetic and epigenetic influences. While the phenotypic distinctions between SAs and other ethnicities in CVD risk are becoming increasingly clear, the biology of these conditions remains an area of active investigation, with emerging studies involving metabolism, genetic variation and epigenetic modifiers (e.g., extracellular RNA). In this review, we describe the current literature on prevalence, prognosis and CVD risk in SAs, and provide a landscape of translational research in this field toward ameliorating CVD risk in SAs.

Rights and Permissions

Citation: Nutr Metab Cardiovasc Dis. 2017 Jan;27(1):32-40. doi: 10.1016/j.numecd.2016.08.001. Epub 2016 Aug 6. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

27612985