Intergenerational Transfer of Epigenetic Information in Sperm

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; UMass Metabolic Network



Document Type



Cell Biology | Cellular and Molecular Physiology | Genetics | Molecular Genetics


The inheritance of information beyond DNA sequence, known as epigenetic inheritance, has been implicated in a multitude of biological processes from control of plant flowering time to cancer in humans. In addition to epigenetic inheritance that occurs in dividing cells of a multicellular organism, it is also increasingly clear that at least some epigenetic information is transmitted via the gametes in a multitude of organisms, including mammals. Here, I review the evidence for epigenetic information carriers in mammalian sperm, and explore the emerging field of intergenerational transfer of environmental information.

Rights and Permissions

Citation: Cold Spring Harb Perspect Med. 2016 May 2;6(5). pii: a022988. 10.1101/cshperspect.a022988. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID