Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network
Letter to the Editor
Biochemistry | Cancer Biology | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
Here we show that CK2 inhibition by CX-4945 destabilizes NOTCH1 and synergizes with JQ1 to induce apoptosis in human T-ALL cells, implicating an alternative strategy to target NOTCH1 signaling in refractory/relapsed T-ALL.
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Copyright © Ferrata Storti Foundation. Haematologica is an open access journal and publisher pdf posted as allowed by author guidelines at http://www.haematologica.org/information-for-authors. Citation: Haematologica. 2017 Jan;102(1):e17-e21. doi: 10.3324/haematol.2016.154013. Epub 2016 Oct 6. Link to article on publisher's site
Lian, Haiwei; Li, Dun; Zhou, Yun; Landesman-Bollag, Esther; Zhang, Guanglan; Anderson, Nicole M.; Tang, Kevin Charles.; Roderick, Justine E.; Kelliher, Michelle A.; Seldin, David C.; Fu, Hui; and Feng, Hui, "CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells" (2017). UMass Metabolic Network Publications. 3.