Challenges and Opportunities in Linking Long Noncoding RNAs to Cardiovascular, Lung, and Blood Diseases
Department of Medicine, Division of Cardiovascular Medicine; UMass Metabolic Network
Biochemistry | Cardiology | Cardiovascular Diseases | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
The new millennium heralds an unanticipated surge of genomic information, most notably an expansive class of long noncoding RNAs (lncRNAs). These transcripts, which now outnumber all protein-coding genes, often exhibit the same characteristics as mRNAs (RNA polymerase II-dependent, 5' methyl-capped, multiexonic, polyadenylated); yet, they do not encode for stable, well-conserved proteins. Elucidating the function of all relevant lncRNAs in heart, vasculature, lung, and blood is essential for generating a complete interactome in these tissues. This is particularly evident because an increasing number of investigators perform RNA-sequencing experiments where, typically, annotated lncRNAs exhibit impressive changes in gene expression. How does one go about evaluating an lncRNA when the sequence of the transcript lends no insight into how it may function within a cell type? Here, we provide a brief overview for the rational study of lncRNAs.
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Citation: Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):21-25. doi: 10.1161/ATVBAHA.116.308513. Epub 2016 Nov 17. Link to article on publisher's site
Freedman, Jane E.; Miano, Joseph M.; and National Heart, Lung, and Blood Institute Workshop Participants, "Challenges and Opportunities in Linking Long Noncoding RNAs to Cardiovascular, Lung, and Blood Diseases" (2017). UMass Metabolic Network Publications. 2.