The mitokine quest(ion)
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
Cells and organisms adapt to mitochondrial dysfunction by activating the mitochondrial unfolded protein response (UPR), which is regulated by mitochondrial-to-nuclear communication; and UPR activation can also be transmitted between different cell types suggesting a role in tissue coordination. Shao and colleagues now identify a neuronal circuit and a secreted neuropeptide required for cell non-autonomous UPR regulation.
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Citation: Cell Res. 2016 Dec;26(12):1265-1266. doi: 10.1038/cr.2016.138. Epub 2016 Nov 25. Link to article on publisher's site
Deng, Pan and Haynes, Cole M., "The mitokine quest(ion)" (2016). UMass Metabolic Network Publications. 13.