Title

The mitokine quest(ion)

UMMS Affiliation

Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network

Date

12-1-2016

Document Type

Article

Disciplines

Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology

Abstract

Cells and organisms adapt to mitochondrial dysfunction by activating the mitochondrial unfolded protein response (UPR), which is regulated by mitochondrial-to-nuclear communication; and UPR activation can also be transmitted between different cell types suggesting a role in tissue coordination. Shao and colleagues now identify a neuronal circuit and a secreted neuropeptide required for cell non-autonomous UPR regulation.

Rights and Permissions

Citation: Cell Res. 2016 Dec;26(12):1265-1266. doi: 10.1038/cr.2016.138. Epub 2016 Nov 25. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

27886169