Department of Molecular, Cell and Cancer Biology
Cancer Biology | Cell Biology | Genetics and Genomics | Molecular Biology
In Drosophila imaginal epithelia, cells mutant for the endocytic neoplastic tumor suppressor gene vps25 stimulate nearby untransformed cells to express Drosophila Inhibitor-of-Apoptosis-Protein-1 (DIAP-1), conferring resistance to apoptosis non-cell autonomously. Here, we show that the non-cell autonomous induction of DIAP-1 is mediated by Yorkie, the conserved downstream effector of Hippo signaling. The non-cell autonomous induction of Yorkie is due to Notch signaling from vps25 mutant cells. Moreover, activated Notch in normal cells is sufficient to induce non-cell autonomous Yorkie activity in wing imaginal discs. Our data identify a novel mechanism by which Notch promotes cell survival non-cell autonomously and by which neoplastic tumor cells generate a supportive microenvironment for tumor growth.
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Citation: PLoS One. 2012;7(6):e37615. doi: 10.1371/journal.pone.0037615. Epub 2012 Jun 5. Link to article on publisher's site
Graves, Hillary K.; Woodfield, Sarah E.; Yang, Chih-Chao; Halder, Georg; and Bergmann, Andreas, "Notch signaling activates Yorkie non-cell autonomously in Drosophila" (2012). Molecular, Cell and Cancer Biology Publications. 73.
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