UMMS Affiliation

Department of Molecular, Cell and Cancer Biology

Date

6-5-2012

Document Type

Article

Disciplines

Cancer Biology | Cell Biology | Genetics and Genomics | Molecular Biology

Abstract

In Drosophila imaginal epithelia, cells mutant for the endocytic neoplastic tumor suppressor gene vps25 stimulate nearby untransformed cells to express Drosophila Inhibitor-of-Apoptosis-Protein-1 (DIAP-1), conferring resistance to apoptosis non-cell autonomously. Here, we show that the non-cell autonomous induction of DIAP-1 is mediated by Yorkie, the conserved downstream effector of Hippo signaling. The non-cell autonomous induction of Yorkie is due to Notch signaling from vps25 mutant cells. Moreover, activated Notch in normal cells is sufficient to induce non-cell autonomous Yorkie activity in wing imaginal discs. Our data identify a novel mechanism by which Notch promotes cell survival non-cell autonomously and by which neoplastic tumor cells generate a supportive microenvironment for tumor growth.

Rights and Permissions

Citation: PLoS One. 2012;7(6):e37615. doi: 10.1371/journal.pone.0037615. Epub 2012 Jun 5. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

22679484

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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