UMMS Affiliation

Department of Molecular, Cell and Cancer Biology

Date

3-10-2016

Document Type

Article

Disciplines

Cancer Biology | Cell Biology | Developmental Biology | Molecular Biology

Abstract

Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensatory proliferation, morphology and cell migration. How caspases are activated under non-apoptotic conditions and process a selective set of substrates without killing the cell remain enigmatic. Here we find that the Drosophila unconventional myosin CRINKLED (CK) selectively interacts with the initiator caspase DRONC and regulates some of its non-apoptotic functions. Loss of CK in the arista, border cells or proneural clusters of the wing imaginal discs affects DRONC-dependent patterning. Our data indicate that CK acts as substrate adaptor, recruiting SHAGGY46/GSK3-beta to DRONC, thereby facilitating caspase-mediated cleavage and localized modulation of kinase activity. Similarly, the mammalian CK counterpart, MYO7A, binds to and impinges on CASPASE-8, revealing a new regulatory axis affecting receptor interacting protein kinase-1 (RIPK1)>CASPASE-8 signalling. Together, our results expose a conserved role for unconventional myosins in transducing caspase-dependent regulation of kinases, allowing them to take part in specific signalling events.

Rights and Permissions

Citation: Nat Commun. 2016 Mar 10;7:10972. doi: 10.1038/ncomms10972. Link to article on publisher's site

Comments

Full author list omitted for brevity. For full list see article.

Related Resources

Link to Article in PubMed

Keywords

Cell signalling, Myosin, Proteases

PubMed ID

26960254

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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