Title

Want reprogramming? Cut back on the chromatin assembly!

UMMS Affiliation

Department of Molecular, Cell and Cancer Biology

Date

9-1-2015

Document Type

Article

Disciplines

Biochemistry | Cell Biology | Developmental Biology | Molecular Biology | Structural Biology

Abstract

Totipotency, the ability of early embryonic cells to generate a complete adult organism as well as extraembryonic tissue, is a fleeting property found only in very early embryonic cells. A breakthrough study now shows that inhibition of DNA replication–linked nucleosome assembly causes embryonic stem cells to resemble totipotent cells. Notably, inhibition of chromatin assembly stimulates reprogramming during somatic-cell nuclear transfer experiments.

Rights and Permissions

Citation: Nat Struct Mol Biol. 2015 Sep;22(9):648-50. doi: 10.1038/nsmb.3081. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

26333710