Autophagy in malignant transformation and cancer progression
Department of Molecular, Cell and Cancer Biology
Cancer Biology | Cell Biology | Cells | Cellular and Molecular Physiology
Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.
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Citation: EMBO J. 2015 Apr 1;34(7):856-880. Epub 2015 Feb 23. Link to article on publisher's site
Galluzzi, Lorenzo; Pietrocola, Federico; Bravo-San Pedro, Jose Manuel; Amaravadi, Ravi K.; Baehrecke, Eric H.; Cecconi, Francesco; Codogno, Patrice; Debnath, Jayanta; Gewirtz, David A.; Karantza, Vassiliki; Kimmelman, Alec; Kumar, Sharad; Levine, Beth; Maiuri, Maria Chiara; Martin, Seamus J.; Penninger, Josef; Piacentini, Mauro; Rubinsztein, David C.; Simon, Hans-Uwe; Simonsen, Anne; Thorburn, Andrew M.; Velasco, Guillermo; Ryan, Kevin M.; and Kroemer, Guido, "Autophagy in malignant transformation and cancer progression" (2015). Molecular, Cell and Cancer Biology Publications. 4.