The Department of Molecular, Cell and Cancer Biology (MCCB) at the University of Massachusetts Medical School was established in 2015, and is the product of a merger between the Program in Gene Function and Expression and the Department of Cancer Biology. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Molecular, Cell and Cancer Biology. See earlier collections for selected Gene Function and Expression and Cancer Biology publications published before the departmental merger.

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Publications from 2017

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Cleaning House: Selective Autophagy of Organelles, Allyson L. Anding and Eric H. Baehrecke

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Molecular Basis and Targeted Inhibition of CBFbeta-SMMHC Acute Myeloid Leukemia, Lucio H. Castilla and John H. Bushweller

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JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias, C. Delgado-Martin, L. K. Meyer, B. J. Huang, M. S. Zinter, J. V. Nguyen, G. A. Smith, J. Taunton, S. S. Winter, Justine R. Roderick, Michelle A. Kelliher, T. M. Horton, B. L. Wood, D. T. Teachey, and M. L. Hermiston

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Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR, Pan Deng and Cole M. Haynes

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Regulation of Pluripotency and Differentiation by Chromatin Remodeling Factors, Ly-Sha Ee

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Clinical application of a cancer genomic profiling assay to guide precision medicine decisions, Cheryl Eifert, Angeliki Pantazi, Ruobai Sun, Jia Xu, Pablo Cingolani, Joerg Heyer, Meaghan Russell, Maria Lvova, Jennifer Ring, Julie Y. Tse, Stephen Lyle, and Alexei Protopopov

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Integrating the UPRmt into the mitochondrial maintenance network, Christopher J. Fiorese and Cole M. Haynes

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Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease, Caitlin E. Fogarty and Andreas Bergmann

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Molecular definitions of autophagy and related processes, Lorenzo Galluzzi, Eric H. Baehrecke, and Guido Kroemer

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Global increase in replication fork speed during a p57KIP2-regulated erythroid cell fate switch, Yung Hwang, Melinda Futran, Daniel Hidalgo, Ramona Pop, Divya Ramalingam Iyer, Ralph Scully, Nicholas R. Rhind, and Merav Socolovsky

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Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation, Hatem E. Kamber Kaya

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An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways, Hatem E. Kamber Kaya, Mark Ditzel, Pascal Meier, and Andreas Bergmann

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CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells, Haiwei Lian, Dun Li, Yun Zhou, Esther Landesman-Bollag, Guanglan Zhang, Nicole M. Anderson, Kevin Charles. Tang, Justine E. Roderick, Michelle A. Kelliher, David C. Seldin, Hui Fu, and Hui Feng

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Complement-Related Regulates Autophagy in Neighboring Cells, Lin Li, Frederico S. L. M. Rodrigues, Christina Kary, Alicia Contet, Mary Logan, Richard H. Baxter G, Will Wood, and Eric H. Baehrecke

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Complement-Related Regulates Autophagy in Neighboring Cells, Lin Lin

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CAF-1 p150 and Ki-67 Regulate Nuclear Structure Throughout the Human Cell Cycle, Timothy D. Matheson

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The p150N domain of chromatin assembly factor-1 regulates Ki-67 accumulation on the mitotic perichromosomal layer, Timothy D. Matheson and Paul D. Kaufman

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Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells, Jose Mercado-Matos, Jennifer L. Clark, Andrew J. Piper, Jenny Janusis, and Leslie M. Shaw

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RUNX1 and breast cancer, Jose Mercado-Matos, Asia N. Matthew-Onabanjo, and Leslie M. Shaw

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A Mechanistic Investigation of Insulin Receptor Substrate 2 Function in Breast Cancer Progression, Jose R. Mercado-Matos

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Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis, Haiwei Mou, Jill Moore, Sunil K. Malonia, Yingxiang Li, Deniz M. Ozata, Soren Hough, Chun-Qing Song, Jordan L. Smith, Andrew H. Fischer, Zhiping Weng, Michael R. Green, and Wen Xue

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CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion, Haiwei Mou, Jordan L. Smith, Lingtao Peng, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Deniz M. Ozata, Yingxiang Li, Charles P. Emerson Jr., Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, and Wen Xue

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MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression, Brian J. Quattrochi, Anushree Gulvady, David R. Driscoll, Makoto Sano, David S. Klimstra, Christopher E. Turner, and Brian C. Lewis

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The mitochondrial unfolded protein response: Signaling from the powerhouse, Mohammed A. Qureshi, Cole M. Haynes, and Mark W. Pellegrino

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Utility of comprehensive genomic sequencing for detecting HER2-positive colorectal cancer, Yoshifumi Shimada, Stephen Lyle, and Toshifumi Wakai

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Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice, Chun-Qing Song, Yingxiang Li, Haiwei Mou, Jill Moore, Angela I. Park, Soren Hough, Zachary Kennedy, Andrew H. Fischer, Darryl Conte Jr., Zhiping Weng, and Wen Xue

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Ki-67 Regulates Cell Cycle Progression and Heterochromatin Organization, Xiaoming Sun

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BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment, Georg E. Winter, Justine E. Roderick, Michelle A. Kelliher, and James E. Bradner

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(CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis, Vildan Betul Yenigun, Mario Sirito, Alla Amcheslavsky, Tomek Czernuszewicz, Jordi Colonques-Bellmunt, Irma Garcia-Alcover, Marzena Wojciechowska, Clare Bolduc, Zhihong Chen, Arturo Lopez Castel, Ralf Krahe, and Andreas Bergmann

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GUIDEseq: a bioconductor package to analyze GUIDE-Seq datasets for CRISPR-Cas nucleases, Lihua Julie Zhu, Michael Lawrence, Ankit Gupta, Herve Pages, Alper Kucukural, Manuel Garber, and Scot A. Wolfe

Publications from 2016

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The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis, N. M. Anderson, Michelle A. Kelliher, and H. Feng

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Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer, Marc A. Becker, Yasir H. Ibrahim, Annabell S. Oh, Dedra H. Fagan, Sara A. Byron, Aaron L. Sarver, Adrian V. Lee, Leslie M. Shaw, Cheng Fan, Charles M. Perou, and Douglas Yee

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Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis, Michael I. Carr, Justine E. Roderick, Hugh S. Gannon, Michelle A. Kelliher, and Stephen N. Jones (Cell reports)

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Requirement and Function of Hippo Pathway Signaling in the Mammalian Gastrointestinal Tract: A Dissertation, Jennifer L. Cotton

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The mitokine quest(ion), Pan Deng and Cole M. Haynes

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The beneficial role of extracellular reactive oxygen species in apoptosis-induced compensatory proliferation, Neha Diwanji and Andreas Bergmann

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Levels of YCG1 Limit Condensin Function during the Cell Cycle: A Dissertation, Tyler W. Doughty

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Levels of Ycg1 Limit Condensin Function during the Cell Cycle, Tyler W. Doughty, Heather E. Arsenault, and Jennifer A. Benanti

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The Impact of mTORC2 Signaling on the Initiation and Progression of KRAS-Driven Pancreatic Neoplasias: A Dissertation, David R. Driscoll

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Investigation of RNA Binding Protein Pumilio as a Genetic Modifier of Mutant CHMP2B in Frontotemporal Dementia (FTD): A Masters Thesis, Xing Du

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The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR, Christopher J. Fiorese, Anna M. Schulz, Yi-Fan Lin, Nadine Rosin, Mark W. Pellegrino, and Cole M. Haynes

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Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages, Caitlin E. Fogarty, Neha Diwanji, Jillian L. Lindblad, Meghana Tare, Alla Amcheslavsky, Kalpana Makhijani, Katja Bruckner, Yun Fan, and Andreas Bergmann

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P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer, Hira Lal Goel, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Rolf A. Brekken, Craig W. Vander Kooi, and Arthur M. Mercurio

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Septate Junction Proteins Play Essential Roles in Morphogenesis Throughout Embryonic Development in Drosophila, Sonia Hall and Robert E. Ward 4th

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Small Molecule Inhibitor of CBFbeta-RUNX Binding for RUNX Transcription Factor Driven Cancers, Anuradha Illendula, John A. Pulikkan, Lucio H. Castilla, and John H. Bushweller

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RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS, Yasushi Ito, Michelle A. Kelliher, and Junying Yuan

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Cancer Metabolism: Fueling More than Just Growth, Namgyu Lee and Dohoon Kim

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The initiator caspase Dronc is subject of enhanced autophagy upon proteasome impairment in Drosophila, T. V. Lee, H. E. Kamber Kaya, Rachel T. Simin, Eric H. Baehrecke, and Andreas Bergmann

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CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN, Diana Legarda, Scott J. Justus, Rosalind L. Ang, Nimisha Rikhi, Wenjing Li, Thomas M. Moran, Jianke Zhang, Emiko Mizoguchi, Matija Zelic, Michelle A. Kelliher, J. Magarian Blander, and Adrian T. Ting

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Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation, Mingli Li, Jillian L. Lindblad, Ernesto Perez, Andreas Bergmann, and Yun Fan

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Tead and AP1 Coordinate Transcription and Motility, Xiangfan Liu, Huapeng Li, Mihir S. Rajurkar, Qi Li, Jennifer L. Cotton, Jianhong Ou, Lihua J. Zhu, Hira L. Goel, Arthur M. Mercurio, Joo-Seop Park, Roger J. Davis, and Junhao Mao

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High-Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML, Leyuan Ma, Justine E. Roderick, Michelle A. Kelliher, and Michael R. Green

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Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity, Julianne Martell, Yonghak Seo, Daniel W. Bak, Samuel F. Kingsley, Heidi A. Tissenbaum, and Eranthie Weerapana

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Radial glia regulate vascular patterning around the developing spinal cord, Ryota L. Matsuoka, Michele Marass, Avdesh Avdesh, Christian S.M. Helker, Hans-Martin Maischein, Ann S. Grosse, Harmandeep Kaur, Nathan D. Lawson, Wiebke Herzog, and Didier Y.R. Stainier

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Genomic landscape of colorectal cancer in Japan: clinical implications of comprehensive genomic sequencing for precision medicine, Masayuki Nagahashi, Toshifumi Wakai, and Stephen R. Lyle

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Clinical expression of facioscapulohumeral muscular dystrophy in carriers of 1-3 D4Z4 reduced alleles: experience of the FSHD Italian National Registry, Ana Nikolic and Rossella Tupler

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Prenatal Maternal Physical Activity and Stem Cells in Umbilical Cord Blood, Sagano Onoyama, Linghua Qiu, Hoi Pang Low, Chien-I Chang, William C. Strohsnitter, Errol R. Norwitz, Mary Lopresti, Kathryn Edmiston, I-Min Lee, Dimitrios Trichopoulos, Pagona Lagiou, and Chung-Cheng Hsieh

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The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles, Mariam H. Orme, Meghana Tare, Andreas Bergmann, and Pascal Meier

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The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles, Mariam H. Orme, Meghana Tare, Andreas Bergmann, and Pascal Meier

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The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L, Victoria E. Pedanou, Stephane Gobeil, Sebastien Tabaries, Tessa M. Simone, Lihua Julie Zhu, Peter M. Siegel, and Michael R. Green

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RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes, Maria Sol Recouvreux, Esteban Nicolas Grasso, Pablo Christian Echeverria, Luciana Rocha-Viegas, Lucio H. Castilla, Carolina Schere-Levy, Johanna Melisa Tocci, Edith Claudia Kordon, and Natalia Rubinstein

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A novel clinical tool to classify facioscapulohumeral muscular dystrophy phenotypes, Giulia Ricci and Rossella Ginevra Tupler

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An autophagy-independent function for Beclin 1 in cancer, Rasika Rohatgi and Leslie M. Shaw

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Activation of WNT/beta-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61, Makoto Sano, David R. Driscoll, Wilfredo E. De Jesus-Monge, Brian J. Quattrochi, Victoria A. Appleman, Jianhong Ou, Lihua (Julie) Zhu, and Brian C. Lewis

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Function of the β4 Integrin in Cancer Stem Cells and Tumor Formation in Breast Cancer: A Masters Thesis, Huayan Sun

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No current evidence for widespread dosage compensation in S. cerevisiae, Eduardo M. Torres, Michael Springer, and Angelika Amon

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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice, Elizabeth C. Townsend, Michelle A. Kelliher, Justine E. Roderick, and David M. Weinstock

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NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kappaB-Dependent and -Independent Functions, Katerina Vlantis, Andy Wullaert, Apostolos Polykratis, Vangelis Kondylis, Marius Dannappel, Robin Schwarzer, Patrick Welz, Teresa Corona, Henning Walczak, Falk Weih, Ulf Klein, Michelle Kelliher, and Manolis Pasparakis

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Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila, Y. Wu, Jillian L. Lindblad, J. Garnett, H. E. Kamber Kaya, D. Xu, Y. Zhao, E. R. Flores, J. Hardy, and Andreas Bergmann

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Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Hao Yin, Chun-Qing Song, Joseph R. Dorkin, Lihua Julie Zhu, Yingxiang Li, Qiongqiong Wu, Angela I. Park, Junghoon Yang, Sneha Suresh, Aizhan Bizhanova, Ankit Gupta, Mehmet Fatih Bolukbasi, Stephen Walsh, Roman L. Bogorad, Guangping Gao, Zhiping Weng, Yizhou Dong, Victor Koteliansky, Scot A. Wolfe, Robert Langer, Wen Xue, and Daniel G. Anderson

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Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine, Tatsuyuki Yoshii, Yingying Geng, Shelly Peyton, Arthur M. Mercurio, and Vincent M. Rotello

Publications from 2015

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The p53R172H Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression, Leanne G. Ahronian, David R. Driscoll, David S. Klimstra, and Brian C. Lewis

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Autophagy in Cell Life and Cell Death, Allyson L. Anding and Eric H. Baehrecke

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Hcm1 integrates signals from Cdk1 and calcineurin to control cell proliferation, Heather E. Arsenault, Jagoree Roy, Claudine E. Mapa, Martha S. Cyert, and Jennifer A. Benanti

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Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants, Ankita Bansal, Lihua Julie Zhu, Kelvin Yen, and Heidi A. Tissenbaum

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Create, activate, destroy, repeat: Cdk1 controls proliferation by limiting transcription factor activity, Jennifer A. Benanti

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TRIMming down tumor suppressors in breast cancer, Sanchita Bhatnagar and Michael R. Green

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Integrating motif, DNA accessibility and gene expression data to build regulatory maps in an organism, Charles Blatti, Majid Kazemian, Scot A. Wolfe, Michael H. Brodsky, and Saurabh Sinha

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DNA-binding-domain fusions enhance the targeting range and precision of Cas9, Mehmet Fatih Bolukbasi, Ankit Gupta, Sarah Oikemus, Alan G. Derr, Manuel Garber, Michael H. Brodsky, Lihua Julie Zhu, and Scot A. Wolfe

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Runx1 is associated with breast cancer progression in MMTV-PyMT transgenic mice and its depletion in vitro inhibits migration and invasion, Gillian Browne, Hanna Taipaleenmaki, Nicole M. Bishop, Sharath C. Madasu, Leslie M. Shaw, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

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Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo, Emerald Butko, Martin Distel, Claire Pouget, Bart Weijts, Isao Kobayashi, Kevin Ng, Christian Mosimann, Fabienne E. Poulain, Adam McPherson, Chih-Wen Ni, David L. Stachura, Natasha Del Cid, Raquel Espin-Palazon, Nathan D. Lawson, Richard Dorsky, Wilson K. Clements, and David Traver

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Function and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer: A Dissertation, Cheng Chang

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A laminin 511 matrix is regulated by TAZ and functions as the ligand for the alpha6Bbeta1 integrin to sustain breast cancer stem cells, Cheng Chang, Hira Lal Goel, Huijie Gao, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Sulev Ingerpuu, Manuel Patarroyo, Shiliang Cao, Elgene Lim, Junhao Mao, Karen Kulju. McKee, Peter D. Yurchenco, and Arthur M. Mercurio

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Function and Regulation of the Tip60-p400 Complex in Embryonic Stem Cells: A Dissertation, Poshen B. Chen

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R loops regulate promoter-proximal chromatin architecture and cellular differentiation, Poshen B. Chen, Hsiuyi V. Chen, Diwash Acharya, Oliver J. Rando, and Thomas G. Fazzio

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Aldehyde Dehydrogenase Is Regulated by beta-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells, Monica Cojoc, Claudia Peitzsch, Ina Kurth, Franziska Trautmann, Leoni A. Kunz-Schughart, Gennady D. Telegeev, Eduard A. Stakhovsky, John R. Walker, Karl Simin, Stephen Lyle, Susanne Fuessel, Kati Erdmann, Manfred P. Wirth, Mechthild Krause, Michael Baumann, and Anna Dubrovska

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Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis, Daniel M. Craig, Stephen P. Ashcroft, Micah Y. Belew, Ben Stocks, Kevin Currell, Keith Baar, and Andrew Philp

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Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice, Wissal El-Assaad, Karim El-Kouhen, Amro H. Mohammad, Jieyi Yang, Masahiro Morita, Isabelle Gamache, Orval Mamer, Daina Avizonis, Nicole M. Hermance, Sander Kersten, Michel L. Tremblay, Michelle A. Kelliher, and Jose G. Teodoro

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The CREB Coactivator CRTC2 Is a Lymphoma Tumor Suppressor that Preserves Genome Integrity through Transcription of DNA Mismatch Repair Genes, Minggang Fang, Magnolia L. Pak, Lynn Chamberlain, Wei Xing, Hongbo Yu, and Michael R. Green

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FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1), Sandra J. Feeney, Meagan J. McGrath, Absorn Sriratana, Stefan M. Gehrig, Gordon S. Lynch, Colleen E. D'Arcy, John T. Price, Catriona A. McLean, Rossella Ginevra Tupler, and Christina A. Mitchell

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The Sound of Silence: Signaling by Apoptotic Cells, Caitlin E. Fogarty and Andreas Bergmann

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Autophagy in malignant transformation and cancer progression, Lorenzo Galluzzi, Federico Pietrocola, Jose Manuel Bravo-San Pedro, Ravi K. Amaravadi, Eric H. Baehrecke, Francesco Cecconi, Patrice Codogno, Jayanta Debnath, David A. Gewirtz, Vassiliki Karantza, Alec Kimmelman, Sharad Kumar, Beth Levine, Maria Chiara Maiuri, Seamus J. Martin, Josef Penninger, Mauro Piacentini, David C. Rubinsztein, Hans-Uwe Simon, Anne Simonsen, Andrew M. Thorburn, Guillermo Velasco, Kevin M. Ryan, and Guido Kroemer

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Gene expression profiling for molecular staging of cutaneous melanoma in patients undergoing sentinel lymph node biopsy, Pedram Gerami, Robert W. Cook, Maria C. Russell, Jeff Wilkinson, Rodabe N. Amaria, Rene Gonzalez, Stephen Lyle, Gilchrist L. Jackson, Anthony J. Greisinger, Clare E. Johnson, Kristen M. Oelschlager, John F. Stone, Derek J. Maetzold, Laura K. Ferris, Jeffrey D. Wayne, Chelsea Cooper, Roxana Obregon, Keith A. Delman, and David Lawson

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Development of a prognostic genetic signature to predict the metastatic risk associated with cutaneous melanoma, Pedram Gerami, Robert W. Cook, Jeff Wilkinson, Maria C. Russell, Navneet Dhillon, Rodabe N. Amaria, Rene Gonzalez, Stephen Lyle, Clare E. Johnson, Kristen M. Oelschlager, Gilchrist L. Jackson, Anthony J. Greisinger, Derek Maetzold, Keith A. Delman, David H. Lawson, and John F. Stone

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Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4, Shawna S. Guillemette, Ryan W. Serra, Min Peng, Janelle A. Hayes, Panagiotis A. Konstantinopoulos, Michael R. Green, and Sharon B. Cantor

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Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF, Sarah J. Hainer, Weifeng Gu, Benjamin R. Carone, Benjamin D. Landry, Oliver J. Rando, Craig C. Mello, and Thomas G. Fazzio

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Venous-derived angioblasts generate organ-specific vessels during embryonic development, Gideon Hen, Julian Nicenboim, Oded Mayseless, Lihee Asaf, Masahiro Shin, Giorgia Busolin, Roy Hofi, Gabriella Almog, Natascia Tiso, Nathan D. Lawson, and Karina Yaniv

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Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity, Simone Hettmer, Michael M. Lin, Daria Tchessalova, Sara J. Tortorici, Alessandra Castiglioni, Tushar Desai, Junhao Mao, Andrew P. McMahon, and Amy J. Wagers

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Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFbeta-SMMHC delays leukemia in mice, Anuradha Illendula, John A. Pulikkan, Hongliang Zong, Jolanta Grembecka, Liting Xue, Siddhartha Sen, Yunpeng Zhou, Adam Boulton, Aravinda Kuntimaddi, Yan Gao, Roger A. Rajewski, Monica L. Guzman, Lucio H. Castilla, and John H. Bushweller

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Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells, Sharanya Iyengar, Melissa Kasheta, and Craig J. Ceol