The Department of Microbiology and Physiological Systems (MaPS) was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology. Capitalizing on the strength of the respective scientific research programs, the resulting department has strong and synergistic expertise in bacterial and viral pathogenesis, immunology, signal transduction, and fundamental cellular physiology. Current departmental research targets include viral and bacterial pathogens affecting the nervous, respiratory, and digestive systems. The mission of the new department is to address important biological questions broadly relevant to infectious disease and encompassing multiple levels of biological organization, including an understanding of pathogen effects on their target organ systems. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Microbiology and Physiological Systems. See earlier collections for selected Physiology and Molecular Genetics and Microbiology publications published before the departmental merger.

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Publications from 2014

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Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour

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Smurf2 regulates hematopoietic stem cell self-renewal and aging, Charusheila Ramkumar, Yahui Kong, Sally E. Trabucco, Rachel M. Gerstein, and Hong Zhang

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Epstein-barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids, Nicholas Renzette, Mohan Somasundaran, Frank E. Brewster, James Coderre, Eric R. Weiss, Margaret M. McManus, Thomas C. Greenough, Barbara Tabak, Manuel Garber, Timothy F. Kowalik, and Katherine Ruiz De Luzuriaga

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The potential of adeno-associated viral vectors for gene delivery to muscle tissue, Dan Wang, Li Zhong, M. Abu Nahid, and Guangping Gao

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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death, Dan Weng, Robyn Lynn Marty-Roix, Sandhya Ganesan, Megan K. Proulx, Gregory I. Vladimer, William J. Kaiser, Edward S. Mocarski, Kimberly Lea Pouliot, Francis Ka-Ming Chan, Michelle A. Kelliher, Phillip A. Harris, John Bertin, Peter J. Gough, Dmitry M. Shayakhmetov, Jon D. Goguen, Katherine A. Fitzgerald, Neal S. Silverman, and Egil Lien

Publications from 2013

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Gene therapy for Canavan's disease takes a step forward, Seemin Seher Ahmed and Guangping Gao

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A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in canavan mice, Seemin Seher Ahmed, Huapeng Li, Chunyan Cao, Elif M. Sikoglu, Andrew R. Denninger, Qin Su, Samuel Eaton, Ana A. Liso Navarro, Jun Xie, Sylvia Szucs, Hongwei Zhang, Constance M. Moore, Daniel A. Kirschner, Thomas N. Seyfried, Terence R. Flotte, Reuben Matalon, and Guangping Gao

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Gene transfer in the liver using recombinant adeno-associated virus, Seemin Seher Ahmed, Jia Li, Jonathan G. Godwin, Guangping Gao, and Li Zhong

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Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in S. cerevisiae, Lars Boeckmann, Yoshimitsu Takahashi, Wei-Chun Au, Prashant K. Mishra, John S. Choy, Anthony R. Dawson, May Y. Szeto, Timothy J. Waybright, Christopher Heger, Christopher McAndrew, Paul K. Goldsmith, Timothy D. Veenstra, Richard E. Baker, and Munira A. Basrai

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A genome wide RNA interference screening method to identify host factors that modulate influenza A virus replication, Christopher R. Chin and Abraham L. Brass

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Crosstalk between casein kinase II and Ste20-related kinase Nak1, Lubos Cipak, Sneha Gupta, Iva Rajovic, Quan-Wen Jin, Dorothea Anrather, Gustav Ammerer, Dannel McCollum, and Juraj Gregan

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Chromatin immunoprecipitation assay of brain tissues using Percoll gradient-purified nuclei, Baojin Ding and Daniel L. Kilpatrick

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Lentiviral vector production, titration, and transduction of primary neurons, Baojin Ding and Daniel L. Kilpatrick

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Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons, Baojin Ding, Wei Wang, Tharakeswari Selvakumar, Hualin Simon Xi, Hong Zhu, Chi-Wing Chow, Jay D. Horton, Richard M. Gronostajski, and Daniel L. Kilpatrick

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A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation, Christopher R. Dowdy, Dana Frederick, Sayyed K. Zaidi, Jennifer L. Colby, Jane B. Lian, Andre J. van Wijnen, Rachel M. Gerstein, Janet L. Stein, and Gary S. Stein

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Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus, Alisha M. Gruntman, Lawrence T. Bish, Christian Mueller, H. Lee Sweeney, Terence R. Flotte, and Guangping Gao

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Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways, Sneha Gupta, Sebastian Mana-Capelli, Janel R. McLean, Chun-Ti Chen, Samriddha Ray, Kathleen L. Gould, and Dannel McCollum

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ROCK inhibitor, Y-27632, reduces FBS-induced structural alteration in organ-cultured mesenteric artery, Yang Hoon Huh, Hee-Seok Kweon, and Toshio Kitazawa

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The CD225 Domain of IFITM3 is Required for both IFITM Protein Association and Inhibition of Influenza A Virus and Dengue Virus Replication, Sinu P. John, Christopher R. Chin, Jill Perreira, Eric M. Feeley, Aaron Aker, George Savidis, Sarah E. Smith, Andrew E. H. Elia, Aaron R. Everitt, Mehul Vora, Thomas Pertel, Stephen J. Elledge, Paul Kellam, and Abraham L. Brass

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Phylogeographic evidence of cognate recognition site patterns and transformation efficiency differences in H. pylori: theory of strain dominance, Ana Maldonado-Contreras, Shrinivasrao P. Mane, Xue-Song Zhang, Luis Pericchi, Teresa Alarcon, Monica Contreras, Bodo Linz, Martin J. Blaser, and Maria Gloria Dominguez-Bello

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High efficiency generalized transduction in Escherichia coli O157:H7, Martin G. Marinus and Anthony R. Poteete

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Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit, Ei Ei Min, Bijoyita Roy, Nadia Amrani, Feng He, and Allan Jacobson

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A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation, Anne M. Mirza and Ronald M. Iorio

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Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta, Bibhuti B. Mishra, Vijay A. K. Rathinam, Gregory W. Martens, Amanda J. Martinot, Hardy Kornfeld, Katherine A. Fitzgerald, and Christopher M. Sassetti

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Infection control in cystic fibrosis: share and share alike, Brian P. O'Sullivan and Christopher M. Sassetti

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Involvement of Escherichia coli DNA Replication Proteins in Phage Lambda Red-Mediated Homologous Recombination, Anthony R. Poteete

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Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1, Charusheila Ramkumar, Hang Cui, Yahui Kong, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang

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Serial Transplantation of Bone Marrow to Test Self-renewal Capacity of Hematopoietic Stem Cells In Vivo, Charusheila Ramkumar, Rachel M. Gerstein, and Hong Zhang

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Rapid intrahost evolution of human cytomegalovirus is shaped by demography and positive selection, Nicholas Renzette, Laura L. Gibson, Bornali Bhattacharjee, Donna Fisher, Mark R. Schleiss, Jeffrey D. Jensen, and Timothy F. Kowalik

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The normalcy of dormancy: common themes in microbial quiescence, Emily S. C. Rittershaus, Seung-Hun Baek, and Christopher M. Sassetti

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Culturing mouse cerebellar granule neurons, Tharakeswari Selvakumar and Daniel L. Kilpatrick

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Gene transfer to the CNS using recombinant adeno-associated virus, Lorelei Stoica, Seemin Seher Ahmed, Guangping Gao, and Miguel Sena-Esteves

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The global translation profile in a ribosomal protein mutant resembles that of an eIF3 mutant, Bayu Sisay Tiruneh, Byung-Hoon Kim, Daniel R. Gallie, Bijoyita Roy, and Albrecht G. von Arnim

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Frameless multimodal image guidance of localized convection-enhanced delivery of therapeutics in the brain, Imramsjah M. J. van der Bom, Richard P. Moser, Guangping Gao, Miguel Sena-Esteves, Neil Aronin, and Matthew J. Gounis

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SU9518 inhibits proliferative vitreoretinopathy in fibroblast and genetically modified Muller cell-induced rabbit models, Gisela Velez, Alexa R. Weingarden, Hetian Lei, Andrius Kazlauskas, and Guangping Gao

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Retinal gene delivery by rAAV and DNA electroporation, Aditya Venkatesh, Shan Ma, Fernanda Langellotto, Guangping Gao, and Claudio Punzo

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UV damage regulates alternative polyadenylation of the RPB2 gene in yeast, Lijian Yu and Michael R. Volkert

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Recombinant adeno-associated virus integration sites in murine liver after ornithine transcarbamylase gene correction, Li Zhong, Nirav Malani, Mengxin Li, Troy Brady, Jun Xie, Peter Bell, Shaoyong Li, Haven Jones, James M. Wilson, Terence R. Flotte, Frederic D. Bushman, and Guangping Gao

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Individual N-glycans added at intervals along the stalk of the Nipah virus G protein prevent fusion but do not block the interaction with the homologous F protein, Qiyun Zhu, Scott B. Biering, Anne M. Mirza, Brittany Grasseschi, Paul J. Mahon, Benhur Lee, Hector C. Aguilar, and Ronald M. Iorio

Publications from 2012

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The Acid-Sensitive, Anesthetic-Activated Potassium Leak Channel, KCNK3, Is Regulated By 14-3-3beta-Dependent, PKC-Mediated Endocytic Trafficking, Luke Gabriel, Anatoli Lvov, Demetra Orthodoxou, Ann R. Rittenhouse, William R. Kobertz, and Haley E. Melikian

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Gene transfer in the lung using recombinant adeno-associated virus, Alisha Gruntman, Christian Mueller, Terence R. Flotte, and Guangping Gao

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Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase, Muneer G. Hasham, Kathy J. Snow, Nina M. Donghia, Jane A. Branca, Mark D. Lessard, Janet Stavnezer, Lindsay S. Shopland, and Kevin D. Mills

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Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation, Julie A. Jonassen, Jovenal T. San Agustin, Stephen P. Baker, and Gregory J. Pazour

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Allele- and tir-independent functions of intimin in diverse animal infection models, Emily M. Mallick, Michael J. Brady, Steven A. Luperchio, Vijay K. Vanguri, Loranne Magoun, Hui Liu, Barbara J. Sheppard, Jean Mukherjee, Arthur Donohue-Rolfe, Saul Tzipori, John M. Leong, and David B. Schauer

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Production and discovery of novel recombinant adeno-associated viral vectors, Christian Mueller, Li Zhong, Dmitry Ratner, Miguel Sena-Esteves, and Guangping Gao

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Rabenosyn-5 Defines the Fate of the Transferrin Receptor Following Clathrin-mediated Endocytosis, Deanna M. Navaroli, Karl D. Bellve, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera

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Smurf2 regulates the senescence response and suppresses tumorigenesis in mice, Charusheila Ramkumar, Yahui Kong, Hang Cui, Suyang Hao, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang

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The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells, Anna J. Ucher, Erin K. Linehan, George W. Teebor, Carol E. Schrader, and Janet Stavnezer

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Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility, Margaretha Van der Deen, Jacqueline Akech, David S. Lapointe, Sneha Gupta, Daniel W. Young, Martin A. Montecino, Mario Galindo, Jane B. Lian, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen

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Long-term, efficient inhibition of microRNA function in mice using rAAV vectors, Jun Xie, Stefan L. Ameres, Randall H. Friedline, Jui-Hung Hung, Yu Zhang, Qing Xie, Li Zhong, Qin Su, Ran He, Mengxin Li, Huapeng Li, Xin Mu, Hongwei Zhang, Jennifer A. Broderick, Jason K. Kim, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

Publications from 2011

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High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism, Jennifer E. Griffin, Jeffrey D. Gawronski, Michael A. Dejesus, Thomas R. Ioerger, Brian J. Akerley, and Christopher M. Sassetti

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Editorial overview, Frances Lund and Janet Stavnezer

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AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus, Sanjay Ranjit, Lyne Khair, Erin K. Linehan, Anna J. Ucher, Mrinmay Chakrabarti, Carol E. Schrader, and Janet Stavnezer

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Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants, Nicholas Renzette, Bornali Bhattacharjee, Jeffrey D. Jensen, Laura L. Gibson, and Timothy F. Kowalik

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A novel zinc binding system, ZevAB, is critical for survival of nontypeable Haemophilus influenzae in a murine lung infection model, Charles V. Rosadini, Jeffrey D. Gawronski, Daniel Raimunda, José M Argüello, and Brian J. Akerley

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Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells, Ori Staszewski, Richard E. Baker, Anna J. Ucher, Raygene Martier, Janet Stavnezer, and Jeroen E. J. Guikema

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Complex regulation and function of activation-induced cytidine deaminase, Janet Stavnezer

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ArcA-regulated glycosyltransferase lic2B promotes complement evasion and pathogenesis of nontypeable Haemophilus influenzae, Sandy M. S. Wong, Frank St. Michael, Andrew Cox, Sanjay Ram, and Brian J. Akerley

Publications from 2010

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p53 represses class switch recombination to IgG2a through its antioxidant function, Jeroen E. J. Guikema, Carol E. Schrader, Michael H. Brodsky, Erin K. Linehan, Adam Richards, Nahla El Falaky, Daniel H. LI, Hayla Karen Sluss, Eva Szomolanyi-Tsuda, and Janet Stavnezer

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The role of Apex2 in class-switch recombination of immunoglobulin genes, Jeroen E. J. Guikema, Janet Stavnezer, and Carol E. Schrader

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Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching, Janet Stavnezer, Andrea Bjorkman, Likun Du, Alberto Cagigi, and Qiang Pan-Hammarstrom