The Department of Microbiology and Physiological Systems (MaPS) was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology. Capitalizing on the strength of the respective scientific research programs, the resulting department has strong and synergistic expertise in bacterial and viral pathogenesis, immunology, signal transduction, and fundamental cellular physiology. Current departmental research targets include viral and bacterial pathogens affecting the nervous, respiratory, and digestive systems. The mission of the new department is to address important biological questions broadly relevant to infectious disease and encompassing multiple levels of biological organization, including an understanding of pathogen effects on their target organ systems. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Microbiology and Physiological Systems. See earlier collections for selected Physiology and Molecular Genetics and Microbiology publications published before the departmental merger.

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Publications from 2016

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A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis, Stephen M. Carpenter, Claudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, and Samuel M. Behar

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Using synthetic biology to make cells tomorrow's test tubes, Hernan G. Garcia, Robert C. Brewster, and Rob Phillips

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Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment, Eliver Eid Ghosn Bou, Jeffrey Waters, Megan Phillips, Ryo Yamamoto, Brian R. Long, Yang Yang, Rachel M. Gerstein, Cheryl A. Stoddart, Hiromitsu Nakauchi, and Leonore A. Herzenberg

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A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance, Li Jiang, Ping Liu, Claudia Bank, Nicholas Renzette, Kristina L. Prachanronarong, L. Safak Yilmaz, Daniel R. Caffrey, Konstantin B. Zeldovich, Celia A. Schiffer, Timothy F. Kowalik, Jeffrey D. Jensen, Robert W. Finberg, Jennifer P. Wang, and Daniel N. Bolon

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N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis, Kenan C. Murphy and Carl F. Nathan

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Genetic link between renal birth defects and congenital heart disease, Jovenal T. San Agustin, Nikolai Klena, Kristi Granath, Ashok Panigrahy, Eileen Stewart, William Devine, Lara Strittmatter, Julie A. Jonassen, Xiaoqin Liu, Cecilia W. Lo, and Gregory J. Pazour

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Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics, George Savidis, William M. McDougall, Paul Meraner, Jill Perreira, Jocelyn M. Portmann, Gaia Trincucci, Sinu P. John, Aaron M. Aker, Nicholas Renzette, Douglas R. Robbins, Zhiru Guo, Sharone Green, Timothy F. Kowalik, and Abraham L. Brass

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The IFITMs Inhibit Zika Virus Replication, George Savidis, Jill Perreira, Jocelyn M. Portmann, Paul Meraner, Zhiru Guo, Sharone Green, and Abraham L. Brass

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Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2, Stefan A. Schattgen, Guangping Gao, Evelyn A. Kurt-Jones, and Katherine A. Fitzgerald

Publications from 2015

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Making the White Matter Matters: Progress in Understanding Canavan's Disease and Therapeutic Interventions Through Eight Decades, Seemin Seher Ahmed and Guangping Gao

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DRC3 connects the N-DRC to dynein g to regulate flagellar waveform, Junya Awata, Kangkang Song, Jianfeng Lin, Stephen M. King, Michael J. Sanderson, Daniela Nicastro, and George B. Witman

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Data from: A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis, Stephen M. Carpenter, Claudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, and Samuel M. Behar

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Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration, Christopher R. Chin, Jill Perreira, George Savidis, Jocelyn M. Portmann, Aaron M. Aker, Eric M. Feeley, Miles C. Smith, and Abraham L. Brass

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Cotton rat immune responses to virus-like particles containing the pre-fusion form of respiratory syncytial virus fusion protein, Lori McGinnes Cullen, Jorge C. G. Blanco, and Trudy G. Morrison

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TRANSIT - A Software Tool for Himar1 TnSeq Analysis, Michael A. DeJesus, Chaitra Ambadipudi, Richard E. Baker, Christopher M. Sassetti, and Thomas R. Ioerger

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AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity, Sebastian P. Fuchs, Jose M. Martinez-Navio, Michael Piatak Jr., Jeffrey D. Lifson, Guangping Gao, and Ronald C. Desrosiers

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Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways, Xing He, Jun Xie, Dongmei Zhang, Qin Su, Xue Sai, Ruipu Bai, Chao Chen, Xufeng Luo, Guangping Gao, and Weiqing Pan

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Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination, Tatenda Kadungure, Anna J. Ucher, Erin K. Linehan, Carol E. Schrader, and Janet Stavnezer

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Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells, Lyne Khair, Richard E. Baker, Erin K. Linehan, Carol E. Schrader, and Janet Stavnezer

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Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria, Karen J. Kieser, Cara C. Boutte, Jemila C. Kester, Christina E. Baer, Amy K. Barczak, Xavier Meniche, Michael C. Chao, E Hesper Rego, Christopher M. Sassetti, Sarah M. Fortune, and Eric J. Rubin

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Murine immune responses to virus-like particle-associated pre- and postfusion forms of the respiratory syncytial virus F protein, Lori McGinnes Cullen, Madelyn R. Schmidt, Sarah A. Kenward, Robert T. Woodland, and Trudy G. Morrison

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Protein conformation in a vaccine matters, Trudy G. Morrison

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HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages, Thomas A. Musich, Olivia O'Connell, Maria Paz Gonzalez-Perez, Cynthia A. Derdeyn, Paul J. Peters, and Paul R. Clapham

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Functional Upregulation of alpha4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward, Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D. Gardner, and Andrew R. Tapper

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Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection, Claudio Nunes-Alves, Matthew G. Booty, Stephen M. Carpenter, Alissa C. Rothchild, Constance J. Martin, Danielle Desjardins, Katherine Steblenko, Henrik N. Kløverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, and Samuel M. Behar

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Data from: Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection, Claudio Nunes-Alves, Matthew G. Booty, Stephen Carpenter, Alissa C. Rothchild, Constance J. Martin, Danielle Desjardins, Katherine Steblenko, Henrik Kloverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, and Samuel M. Behar

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A chimeric EBV gp350/220-based VLP replicates the virion B-cell attachment mechanism and elicits long-lasting neutralizing antibodies in mice, Javier Gordon Ogembo, Matthew R. Muraswki, Lori McGinnes, Agapi Parcharidou, Rujapak Sutiwisesak, Timelia Tison, Juan Avendano, Deep Agnani, Robert W. Finberg, Trudy G. Morrison, and Joyce D. Fingeroth

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RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus, Jill Perreira, Aaron Aker, George Savidis, Christopher R. Chin, William M. McDougall, Jocelyn M. Portmann, Paul Meraner, Miles Smith, Motiur Rahman, Richard E. Baker, Annick Gauthier, Michael Franti, and Abraham L. Brass

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Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes, Paul J. Peters, Maria Paz Gonzalez-Perez, Thomas A. Musich, Tiffany A. Moore Simas, Rongheng Lin, Abraham N. Morse, Robin J. Shattock, Cynthia A. Derdeyn, and Paul R. Clapham

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Reversion From Methicillin Susceptibility to Methicillin Resistance in Staphylococcus aureus During Treatment of Bacteremia, Megan K. Proulx, Samantha G. Palace, Sumanth Gandra, Brenda Torres, Susan Weir, Tracy Stiles, Richard T. Ellison III, and Jon D. Goguen

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On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity, Nicholas Renzette, Timothy F. Kowalik, and Jeffrey D. Jensen

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Limits and patterns of cytomegalovirus genomic diversity in humans, Nicholas Renzette, Cornelia Pokalyuk, Laura Gibson, Bornali Bhattacharjee, Mark R. Schleiss, Klaus Hamprecht, Aparecida Y. Yamamoto, Marisa M. Mussi-Pinhata, William J. Britt, Jeffrey D. Jensen, and Timothy F. Kowalik

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Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels, Mandy L. Roberts-Crowley and Ann R. Rittenhouse

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Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts, Charles A. Specht, Chrono K. Lee, Haibin Huang, Donald J. Tipper, Zu T. Shen, Jennifer K. Lodge, John D. Leszyk, Gary R. Ostroff, and Stuart M. Levitz

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Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan, Cara M. Weismann, Jennifer Ferreira, Allison M. Keeler, Qin Su, Linghua Qiu, Scott A. Shaffer, Zuoshang Xu, Guangping Gao, and Miguel Sena-Esteves

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Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment, Konstantin B. Zeldovich, Ping Liu, Nicholas Renzette, Matthieu Foll, Serena T. Pham, Sergey V. Venev, Glen R. Gallagher, Daniel N. Bolon, Evelyn A. Kurt-Jones, Jeffrey D. Jensen, Daniel R. Caffrey, Celia A. Schiffer, Timothy F. Kowalik, Jennifer P. Wang, and Robert W. Finberg

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Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal, Rubing Zhao-Shea, Steven Degroot, Liwang Liu, Markus Vallaster, Xueyan Pang, Qin Su, Guangping Gao, Oliver J. Rando, Gilles E. Martin, Olivier George, Paul D. Gardner, and Andrew R. Tapper

Publications from 2014

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A deterministic model predicts the properties of stochastic calcium oscillations in airway smooth muscle cells, Pengxing Cao, Xiahui Tan, Graham Donovan, Michael J. Sanderson, and James Sneyd

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IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion, Tanay M. Desai, Mariana Marin, Christopher R. Chin, George Savidis, Abraham L. Brass, and Gregory B. Melikyan

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Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour

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Influenza virus drug resistance: a time-sampled population genetics perspective, Matthieu Foll, Yu Ping Poh, Nicholas Renzette, Anna Ferrer Admetlla, Claudia Bank, Hyunjin Shim, Anna Sapfo Malaspinas, Gregory Ewing, Ping Liu, Daniel Wegmann, Daniel R. Caffrey, Konstantin B. Zeldovich, Daniel N. A. Bolon, Jennifer Wang, Timothy F. Kowalik, Celia A. Schiffer, Robert W. Finberg, and Jeffrey D. Jensen

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ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination, Lyne Khair, Jeroen E. J. Guikema, Erin K. Linehan, Anna J. Ucher, Niek G.J. Leus, Colin Ogilvie, Zhenkun Lou, Carol E. Schrader, and Janet Stavnezer

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The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment, Emily M. Mallick, John J. Garber, Vijay K. Vanguri, Sowmya Balasubramanian, Timothy Blood, Stacie Clark, Didier F. Vingadassalom, Christopher Louissaint, Beth A. McCormick, Scott B. Snapper, and John M. Leong

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Macrophages clean up: efferocytosis and microbial control, Constance J. Martin, Kristen N. Peters, and Samuel M. Behar

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In search of a new paradigm for protective immunity to TB, Claudio Nunes-Alves, Matthew G. Booty, Stephen Carpenter, Pushpalatha Jayaraman, Alissa C. Rothchild, and Samuel M. Behar

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Genome-wide mutant fitness profiling identifies nutritional requirements for optimal growth of Yersinia pestis in deep tissue, Samantha G. Palace, Megan K. Proulx, Shan Lu, Richard E. Baker, and Jon D. Goguen

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Dicer expression is essential for adult midbrain dopaminergic neuron maintenance and survival, Xueyan Pang, Eric M. Hogan, Alison Casserly, Guangping Gao, Paul D. Gardner, and Andrew R. Tapper

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Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses, Min Peng, Jenny X. Xie, Anna J. Ucher, Janet Stavnezer, and Sharon B. Cantor

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Smurf2 regulates hematopoietic stem cell self-renewal and aging, Charusheila Ramkumar, Yahui Kong, Sally E. Trabucco, Rachel M. Gerstein, and Hong Zhang

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Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro, Nicholas Renzette, Daniel R. Caffrey, Konstantin B. Zeldovich, Ping Liu, Glen R. Gallagher, Daniel Aiello, Alyssa J. Porter, Evelyn A. Kurt-Jones, Daniel N. Bolon, Yu-Ping Poh, Jeffrey D. Jensen, Celia A. Schiffer, Timothy F. Kowalik, Robert W. Finberg, and Jennifer P. Wang

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Epstein-barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids, Nicholas Renzette, Mohan Somasundaran, Frank E. Brewster, James Coderre, Eric R. Weiss, Margaret M. McManus, Thomas C. Greenough, Barbara Tabak, Manuel Garber, Timothy F. Kowalik, and Katherine Ruiz De Luzuriaga

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Outer membrane protein P5 is required for resistance of nontypeable Haemophilus influenzae to both the classical and alternative complement pathways, Charles V. Rosadini, Sanjay Ram, and Brian J. Akerley

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iNKT cell production of GM-CSF controls Mycobacterium tuberculosis, Alissa C. Rothchild, Pushpa Jayaraman, Claudio Nunes-Alves, and Samuel M. Behar

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Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation, Janet Stavnezer, Erin K. Linehan, Mikayla R. Thompson, Ghaith Habboub, Anna J. Ucher, Tatenda Kadungure, Daisuke Tsuchimoto, Yusaku Nakabeppu, and Carol E. Schrader

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IgH chain class switch recombination: mechanism and regulation, Janet Stavnezer and Carol E. Schrader

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Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching, Anna J. Ucher, Srijana Ranjit, Tatenda Kadungure, Erin K. Linehan, Lyne Khair, Elaine Xie, Jennifer Limauro, Katherina S. Rauch, Carol E. Schrader, and Janet Stavnezer

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mu-Opioid inhibition of Ca2+ currents and secretion in isolated terminals of the neurohypophysis occurs via ryanodine-sensitive Ca2+ stores, Cristina M. Velazquez-Marrero, Sonia Ortiz-Miranda, Hector G. Marrero, Edward E. Custer, Steven N. Treistman, and Jose R. Lemos

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The potential of adeno-associated viral vectors for gene delivery to muscle tissue, Dan Wang, Li Zhong, M. Abu Nahid, and Guangping Gao

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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death, Dan Weng, Robyn Lynn Marty-Roix, Sandhya Ganesan, Megan K. Proulx, Gregory I. Vladimer, William J. Kaiser, Edward S. Mocarski, Kimberly Lea Pouliot, Francis Ka-Ming Chan, Michelle A. Kelliher, Phillip A. Harris, John Bertin, Peter J. Gough, Dmitry M. Shayakhmetov, Jon D. Goguen, Katherine A. Fitzgerald, Neal S. Silverman, and Egil Lien

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Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10, Bin Yang, Shaoyong Li, Hongyan Wang, Yansu Guo, Dominic J. Gessler, Chunyan Cao, Qin Su, Joshua Kramer, Li Zhong, Seemin Seher Ahmed, Hongwei Zhang, Ran He, Ronald C. Desrosiers, Robert H. Brown Jr., Zuoshang Xu, and Guangping Gao

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Allele-specific induction of IL-1beta expression by C/EBPbeta and PU.1 contributes to increased tuberculosis susceptibility, Guoliang Zhang, Boping Zhou, Shaoyuan Li, Jun Yue, Hui Yang, Yuxin Wen, Senlin Zhan, Wenfei Wang, Mingfeng Liao, Mingxia Zhang, Gucheng Zeng, Carl G. Feng, Christopher M. Sassetti, and Xinchun Chen

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Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents, Jian Zhu, Jill Perreira, Christopher R. Chin, Richard E. Baker, Louise Maranda, Stephen J. Elledge, and Abraham L. Brass

Publications from 2013

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Gene therapy for Canavan's disease takes a step forward, Seemin Seher Ahmed and Guangping Gao

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A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in canavan mice, Seemin Seher Ahmed, Huapeng Li, Chunyan Cao, Elif M. Sikoglu, Andrew R. Denninger, Qin Su, Samuel Eaton, Ana A. Liso Navarro, Jun Xie, Sylvia Szucs, Hongwei Zhang, Constance M. Moore, Daniel A. Kirschner, Thomas N. Seyfried, Terence R. Flotte, Reuben Matalon, and Guangping Gao

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Gene transfer in the liver using recombinant adeno-associated virus, Seemin Seher Ahmed, Jia Li, Jonathan G. Godwin, Guangping Gao, and Li Zhong

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Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in S. cerevisiae, Lars Boeckmann, Yoshimitsu Takahashi, Wei-Chun Au, Prashant K. Mishra, John S. Choy, Anthony R. Dawson, May Y. Szeto, Timothy J. Waybright, Christopher Heger, Christopher McAndrew, Paul K. Goldsmith, Timothy D. Veenstra, Richard E. Baker, and Munira A. Basrai

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A genome wide RNA interference screening method to identify host factors that modulate influenza A virus replication, Christopher R. Chin and Abraham L. Brass

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Crosstalk between casein kinase II and Ste20-related kinase Nak1, Lubos Cipak, Sneha Gupta, Iva Rajovic, Quan-Wen Jin, Dorothea Anrather, Gustav Ammerer, Dannel McCollum, and Juraj Gregan

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Chromatin immunoprecipitation assay of brain tissues using Percoll gradient-purified nuclei, Baojin Ding and Daniel L. Kilpatrick

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Lentiviral vector production, titration, and transduction of primary neurons, Baojin Ding and Daniel L. Kilpatrick

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Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons, Baojin Ding, Wei Wang, Tharakeswari Selvakumar, Hualin Simon Xi, Hong Zhu, Chi-Wing Chow, Jay D. Horton, Richard M. Gronostajski, and Daniel L. Kilpatrick

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A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation, Christopher R. Dowdy, Dana Frederick, Sayyed K. Zaidi, Jennifer L. Colby, Jane B. Lian, Andre J. van Wijnen, Rachel M. Gerstein, Janet L. Stein, and Gary S. Stein

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Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus, Alisha M. Gruntman, Lawrence T. Bish, Christian Mueller, H. Lee Sweeney, Terence R. Flotte, and Guangping Gao

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Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways, Sneha Gupta, Sebastian Mana-Capelli, Janel R. McLean, Chun-Ti Chen, Samriddha Ray, Kathleen L. Gould, and Dannel McCollum

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ROCK inhibitor, Y-27632, reduces FBS-induced structural alteration in organ-cultured mesenteric artery, Yang Hoon Huh, Hee-Seok Kweon, and Toshio Kitazawa

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Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis, Thomas R. Ioerger, Theresa O'Malley, Reiling Liao, Kristine M. Guinn, Mark J. Hickey, Nilofar Mohaideen, Kenan C. Murphy, Helena I. Boshoff M, Valerie Mizrahi, Eric J. Rubin, Christopher M. Sassetti, Clifton E. Barry III, David R. Sherman, Tanya Parish, and James C. Sacchettini

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CD28 and ITK signals regulate autoreactive T cell trafficking, Nitya Jain, Bing Miu, Jian-kang Jiang, Kai K. McKinstry, Amanda L. Prince, Susan L. Swain, Dale L. Greiner, Craig J. Thomas, Michael J. Sanderson, Leslie J. Berg, and Joonso Kang

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Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence, Dakshina M. Jandhyala, Vijay K. Vanguri, Erik J. Boll, YuShuan (Cindy) Lai, Beth A. McCormick, and John M. Leong

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The CD225 Domain of IFITM3 is Required for both IFITM Protein Association and Inhibition of Influenza A Virus and Dengue Virus Replication, Sinu P. John, Christopher R. Chin, Jill Perreira, Eric M. Feeley, Aaron Aker, George Savidis, Sarah E. Smith, Andrew E. H. Elia, Aaron R. Everitt, Mehul Vora, Thomas Pertel, Stephen J. Elledge, Paul Kellam, and Abraham L. Brass

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Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli, YuShuan (Cindy) Lai, Ilan Rosenshine, John M. Leong, and Gad Frankel

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Host genetic determinants of influenza pathogenicity, Tsai-Yu Lin and Abraham L. Brass

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Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction, Tsai-Yu Lin, Christopher R. Chin, Aaron R. Everitt, Simon Clare, Jill Perreira, George Savidis, Aaron M. Aker, Sinu P. John, David Sarlah, Erick M. Carreira, Stephen J. Elledge, Paul Kellam, and Abraham L. Brass

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Phylogeographic evidence of cognate recognition site patterns and transformation efficiency differences in H. pylori: theory of strain dominance, Ana Maldonado-Contreras, Shrinivasrao P. Mane, Xue-Song Zhang, Luis Pericchi, Teresa Alarcon, Monica Contreras, Bodo Linz, Martin J. Blaser, and Maria Gloria Dominguez-Bello

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High efficiency generalized transduction in Escherichia coli O157:H7, Martin G. Marinus and Anthony R. Poteete

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Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit, Ei Ei Min, Bijoyita Roy, Nadia Amrani, Feng He, and Allan Jacobson

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A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation, Anne M. Mirza and Ronald M. Iorio

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Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta, Bibhuti B. Mishra, Vijay A. K. Rathinam, Gregory W. Martens, Amanda J. Martinot, Hardy Kornfeld, Katherine A. Fitzgerald, and Christopher M. Sassetti

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Tolerance has its limits: how the thymus copes with infection, Claudio Nunes-Alves, Claudia Nobrega, Samuel M. Behar, and Margarida Correia-Neves

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Infection control in cystic fibrosis: share and share alike, Brian P. O'Sullivan and Christopher M. Sassetti

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Involvement of Escherichia coli DNA Replication Proteins in Phage Lambda Red-Mediated Homologous Recombination, Anthony R. Poteete

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Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1, Charusheila Ramkumar, Hang Cui, Yahui Kong, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang

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Serial Transplantation of Bone Marrow to Test Self-renewal Capacity of Hematopoietic Stem Cells In Vivo, Charusheila Ramkumar, Rachel M. Gerstein, and Hong Zhang

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Rapid intrahost evolution of human cytomegalovirus is shaped by demography and positive selection, Nicholas Renzette, Laura L. Gibson, Bornali Bhattacharjee, Donna Fisher, Mark R. Schleiss, Jeffrey D. Jensen, and Timothy F. Kowalik

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The normalcy of dormancy: common themes in microbial quiescence, Emily S. C. Rittershaus, Seung-Hun Baek, and Christopher M. Sassetti

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Translational Regulation of Cytoplasmic mRNAs, Bijoyita Roy and Albrecht G. von Arnim

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DNA polymerases beta and lambda do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations, Carol E. Schrader, Erin K. Linehan, Anna J. Ucher, Barbara Bertocci, and Janet Stavnezer

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Culturing mouse cerebellar granule neurons, Tharakeswari Selvakumar and Daniel L. Kilpatrick

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Gene transfer to the CNS using recombinant adeno-associated virus, Lorelei Stoica, Seemin Seher Ahmed, Guangping Gao, and Miguel Sena-Esteves