The Department of Microbiology and Physiological Systems (MaPS) was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology. Capitalizing on the strength of the respective scientific research programs, the resulting department has strong and synergistic expertise in bacterial and viral pathogenesis, immunology, signal transduction, and fundamental cellular physiology. Current departmental research targets include viral and bacterial pathogens affecting the nervous, respiratory, and digestive systems. The mission of the new department is to address important biological questions broadly relevant to infectious disease and encompassing multiple levels of biological organization, including an understanding of pathogen effects on their target organ systems. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of Microbiology and Physiological Systems. See earlier collections for selected Physiology and Molecular Genetics and Microbiology publications published before the departmental merger.

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Publications from 2017

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Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery, Jianzhong Ai, Jia Li, Dominic J. Gessler, Qin Su, Qiang Wei, Hong Li, and Guangping Gao

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mRNA Decay Pathways Use Translation Fidelity and Competing Decapping Complexes for Substrate Selection, Alper Celik

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High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection, Alper Celik, Richard E. Baker, Feng He, and Allan Jacobson

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Effect of transcription factor resource sharing on gene expression noise, Dipjyoti Das, Supravat Dey, Robert C. Brewster, and Sandeep Choubey (PLoS computational biology, 4-17-2017)

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Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis, Michael A. DeJesus, Elias R. Gerrick, Weizhen Xu, Sae Woong. Park, Jarukit E. Long, Cara C. Boutte, Eric J. Rubin, Dirk Schnappinger, Sabine Ehrt, Sarah M. Fortune, Christopher M. Sassetti, and Thomas R. Ioerger

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Statistical analysis of genetic interactions in Tn-Seq data, Michael A. DeJesus, Subhalaxmi Nambi, Clare M. Smith, Richard E. Baker, Christopher M. Sassetti, and Thomas R. Ioerger

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AAV Is Now a Medicine: We Had Better Get This Right, Terence R. Flotte and Guangping Gao

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Unravelling the pleiotropic role of the MceG ATPase in Mycobacterium smegmatis, Julia Garcia-Fernandez, Kadamba Papavinasasundaram, Beatriz Galan, Christopher M. Sassetti, and Jose L. Garcia

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Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease, Dominic J. Gessler, Danning Li, Hongxia Xu, Qin Su, Julio Sanmiguel, Serafettin Tuncer, Constance M. Moore, Jean A. King, Reuben Matalon, and Guangping Gao

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Intracranial AAV-IFN-beta gene therapy eliminates invasive xenograft glioblastoma and improves survival in orthotopic syngeneic murine model, Dwijit Guhasarkar, James Neiswender, Qin Su, Guangping Gao, and Miguel Sena-Esteves

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Role of Tim3 in Mediating T Cell Exhaustion During Chronic Mycobacterium Tuberculosis Infection, Miye K. Jacques

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AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy, Motohiro Kano, Amanda E. Sosulski, LiHua Zhang, Hatice D. Saatcioglu, Dan Wang, Nicholas Nagykery, Mary E. Sabatini, Guangping Gao, Patricia K. Donahoe, and David Pepin

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Airway smooth muscle dysfunction in Pompe (Gaa-/-) mice, Allison M. Keeler, Donghai Lui, Marina Zieger, Lang Xiong, Jeffrey Salemi, Karl D. Bellve, Barry J. Byrne, David D. Fuller, Ronghua ZhuGe, and Mai K. Elmallah

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Self-consistent theory of transcriptional control in complex regulatory architectures, Jasper Landman, Robert C. Brewster, Franz M. Weinert, Rob Phillips, and Willem K. Kegel (PloS one, 7-7-2017)

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Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice, Patrick Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Karen Kodys, Donna Catalano, Doyle V. Ward, and Gyongyi Szabo

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Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform, Jeremy M. Rock, Forrest F. Hopkins, Alejandro Chavez, Marieme Diallo, Michael R. Chase, Elias R. Gerrick, Justin R. Pritchard, George M. Church, Eric J. Rubin, Christopher M. Sassetti, Dirk Schnappinger, and Sarah M. Fortune

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Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein, Maoxue Tang, Guangping Gao, Huapeng Li, Qin Su, Darryl C. De Vivo, and Umrao R. Monani

Publications from 2016

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rAAV Gene Therapy in a Canavan's Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System, Seemin Seher Ahmed, Stefan A. Schattgen, Ashley E. Frakes, Elif M. Sikoglu, Qin Su, Jia Li, Thomas G. Hampton, Andrew R. Denninger, Daniel A. Kirschner, Brian Kaspar, Reuben Matalon, and Guangping Gao

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IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection, Matthew G. Booty, Palmira Barreira-Silva, Stephen Carpenter, Claudio Nunes-Alves, Miye K. Jacques, Britni L. Stowell, Pushpalatha Jayaraman, Gillian Beamer, and Samuel M. Behar

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A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis, Cara C. Boutte, Christina E. Baer, Kadamba Papavinasasundaram, Weiru Liu, Michael R. Chase, Xavier Meniche, Sarah M. Fortune, Christopher M. Sassetti, Thomas R. Ioerger, and Eric J. Rubin

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xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation, Yi Cai, Subhalaxmi Nambi, Christopher M. Sassetti, Fudi Wang, and Xinchun Chen

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Memory CD8+ T Cell Function during Mycobacterium Tuberculosis Infection: A Dissertation, Stephen M. Carpenter

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A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis, Stephen M. Carpenter, Claudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, and Samuel M. Behar

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Utilizing a TLR5-Adjuvanted Cytomegalovirus as a Lentiviral Vaccine in the Nonhuman Primate Model for AIDS, Jesse D. Deere, W L. Chang William, Luis D. Castillo, Kim A. Schmidt, Hung T. Kieu, Nicholas Renzette, Timothy F. Kowalik, Stephen W. Barthold, Barbara L. Shacklett, Peter A. Barry, and Ellen E. Sparger

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Reciprocal autoregulation by NFI occupancy and ETV1 promotes the developmental expression of dendrite-synapse genes in cerebellar granule neurons, Baojin Ding, John W. Cave, Paul R. Dobner, Debra Mullikin-Kilpatrick, Marina Bartzokis, Hong Zhu, Chi-Wing Chow, Richard M. Gronostajski, and Daniel Lee Kilpatrick

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Unexpected role of interferon-gamma in regulating neuronal connectivity and social behaviour, Anthony J. Filiano, Yang Xu, Nicholas J. Tustison, Rachel L. Marsh, Wendy Baker, Igor Smirnov, Christopher C. Overall, Sachin P. Gadani, Stephen D. Turner, Zhiping Weng, Sayeda Najamussaha Peerzade, Hao Chen, Kevin S. Lee, Michael M. Scott, Mark P. Beenhakker, Vladimir Litvak, and Jonathan Kipnis

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RNA activation of haploinsufficient Foxg1 gene in murine neocortex, Cristina Fimiani, Elisa Goina, Qin Su, Guangping Gao, and Antonello Mallamaci

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Recombinant AAV Vectors for Enhanced Expression of Authentic IgG, Sebastian P. Fuchs, Jose M. Martinez-Navio, Guangping Gao, and Ronald C. Desrosiers

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Using synthetic biology to make cells tomorrow's test tubes, Hernan G. Garcia, Robert C. Brewster, and Rob Phillips (Integrative biology : quantitative biosciences from nano to macro, 3-8-2016)

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Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment, Eliver Eid Ghosn Bou, Jeffrey Waters, Megan Phillips, Ryo Yamamoto, Brian R. Long, Yang Yang, Rachel M. Gerstein, Cheryl A. Stoddart, Hiromitsu Nakauchi, and Leonore A. Herzenberg

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Spatially distinct and metabolically active membrane domain in mycobacteria, Jennifer M. Hayashi, John D. Leszyk, Christina E. Baer, Scott A. Shaffer, Christopher M. Sassetti, and Yasu S. Morita

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TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection, Pushpalatha Jayaraman, Miye K. Jacques, Chen Zhu, Katherine Steblenko, Britni L. Stowell, Asaf Madi, Ana C. Anderson, Vijay K. Kuchroo, and Samuel M. Behar

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A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance, Li Jiang, Ping Liu, Claudia Bank, Nicholas Renzette, Kristina L. Prachanronarong, L. Safak Yilmaz, Daniel R. Caffrey, Konstantin B. Zeldovich, Celia A. Schiffer, Timothy F. Kowalik, Jeffrey D. Jensen, Robert W. Finberg, Jennifer P. Wang, and Daniel N. Bolon

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Consensus Paper: Cerebellar Development, Ketty Leto, Baojin Ding, and Daniel Lee Kilpatrick

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Chewing the fat: lipid metabolism and homeostasis during M. tuberculosis infection, Rustin R. Lovewell, Christopher M. Sassetti, and Brian C. VanderVen

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N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis, Kenan C. Murphy and Carl F. Nathan

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SUMO-Targeted Ubiquitin Ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin, Kentaro Ohkuni, Yoshimitsu Takahashi, Alyona Fulp, Josh Lawrimore, Wei-Chun Au, Nagesh Pasupala, Reuben Levy-Myers, Jack Warren, Alexander Strunnikov, Richard E. Baker, Oliver Kerscher, Kerry Bloom, and Munira A. Basrai

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Metabolic crosstalk between host and pathogen: sensing, adapting and competing, Andrew J. Olive and Christopher M. Sassetti

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Plague and the Defeat of Mammalian Innate Immunity: Systematic Genetic Analysis of Yersinia pestis Virulence Factors: A Dissertation, Samantha G. Palace

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Fine-tuning of Substrate Affinity Leads to Alternative Roles of Mycobacterium tuberculosis Fe2+-ATPases, Sarju J. Patel, Brianne E. Lewis, Jarukit E. Long, Subhalaxmi Nambi, Christopher M. Sassetti, Timothy L. Stemmler, and Jose M. Arguello

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Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase, Kristina L. Prachanronarong, Aysegul Ozen, Kelly Thayer, L. Safak Yilmaz, Konstantin B. Zeldovich, Daniel N. Bolon, Timothy F. Kowalik, Jeffrey D. Jensen, Robert W. Finberg, Jennifer P. Wang, Nese Kurt Yilmaz, and Celia A. Schiffer

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Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site, Daniil M. Prigozhin, Kadamba Papavinasasundaram, Christina E. Baer, Kenan C. Murphy, Alisa Moskaleva, Tony Y. Chen, Tom Alber, and Christopher M. Sassetti

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The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation, Dmitry Ratner, M. Pontus A. Orning, Megan K. Proulx, Donghai Wang, Mikhail A. Gavrilin, Mark D. Wewers, Emad S. Alnemri, Peter F. Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D. Goguen, and Egil Lien

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Identification of Essential Metabolic and Genetic Adaptations to the Quiescent State in Mycobacterium Tuberculosis: A Dissertation, Emily S. C. Rittershaus

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Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression, Bijoyita Roy, Westley J. Friesen, Yuki Tomizawa, John D. Leszyk, Jin Zhuo, Briana Johnson, Jumana Dakka, Christopher R. Trotta, Xiaojiao Xue, Venkateshwar Mutyam, Kim M. Keeling, James A. Mobley, Steven M. Rowe, David M. Bedwell, Ellen M. Welch, and Allan Jacobson

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Genetic link between renal birth defects and congenital heart disease, Jovenal T. San Agustin, Nikolai Klena, Kristi Granath, Ashok Panigrahy, Eileen Stewart, William Devine, Lara Strittmatter, Julie A. Jonassen, Xiaoqin Liu, Cecilia W. Lo, and Gregory J. Pazour

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Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion, David E. Saslowsky, Jay R. Thiagarajah, Beth A. McCormick, Jean C. Lee, and Wayne I. Lencer

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Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics, George Savidis, William M. McDougall, Paul Meraner, Jill Perreira, Jocelyn M. Portmann, Gaia Trincucci, Sinu P. John, Aaron M. Aker, Nicholas Renzette, Douglas R. Robbins, Zhiru Guo, Sharone Green, Timothy F. Kowalik, and Abraham L. Brass

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The IFITMs Inhibit Zika Virus Replication, George Savidis, Jill Perreira, Jocelyn M. Portmann, Paul Meraner, Zhiru Guo, Sharone Green, and Abraham L. Brass

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Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2, Stefan A. Schattgen, Guangping Gao, Evelyn A. Kurt-Jones, and Katherine A. Fitzgerald

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Recombinant Adeno-Associated Virus Serotype 6 (rAAV6) Potently and Preferentially Transduces Rat Astrocytes In vitro and In vivo, Alexandra L. Schober, Dmitriy A. Gagarkin, Ying Chen, Guangping Gao, Lauren Jacobson, and Alexander A. Mongin

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Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype, Clare M. Smith, Megan K. Proulx, Andrew J. Olive, Dominick Laddy, Bibhuti B. Mishra, Caitlin Moss, Nuria Martinez, Michelle M. Bellerose, Palmira Barreira-Silva, Jia Yao Phuah, Richard E. Baker, Samuel M. Behar, Hardy Kornfeld, Thomas G. Evans, Gillian Beamer, and Christopher M. Sassetti

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Scaffolded Antigens in Yeast Cell Particle Vaccines Provide Protection against Systemic Polyoma Virus Infection, Donald J. Tipper and Eva Szomolanyi-Tsuda

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YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis, Sally E. Trabucco, Rachel M. Gerstein, and Hong Zhang (Journal of immunology (Baltimore, Md. : 1950))

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RNA polymerase II depletion promotes transcription of alternative mRNA species, Lijian Yu, Mayuri Rege, Craig L. Peterson, and Michael R. Volkert

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The molecular basis of the genesis of basal tone in internal anal sphincter, Cheng-Hai Zhang, Donghai Lui, Ping Lu, Kaizhi Zheng, Siobhan M. Craige, Lawrence Lifshitz, John F. Keaney Jr., Kevin E. Fogarty, Ronghua Zhuge, and Min-Sheng Zhu

Publications from 2015

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Making the White Matter Matters: Progress in Understanding Canavan's Disease and Therapeutic Interventions Through Eight Decades, Seemin Seher Ahmed and Guangping Gao

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DRC3 connects the N-DRC to dynein g to regulate flagellar waveform, Junya Awata, Kangkang Song, Jianfeng Lin, Stephen M. King, Michael J. Sanderson, Daniela Nicastro, and George B. Witman (Molecular biology of the cell)

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Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma, Kenneth I. Berns, Barry J. Byrne, Terence R. Flotte, Guang Ping Gao, William W. Hauswirth, Roland W. Herzog, Nicholas Muzyczka, Thierry VandenDriessche, Xiao Xiao, Sergei Zolotukhin, and Arun Srivastava

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Data from: A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis, Stephen M. Carpenter, Claudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, and Samuel M. Behar

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Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration, Christopher R. Chin, Jill Perreira, George Savidis, Jocelyn M. Portmann, Aaron M. Aker, Eric M. Feeley, Miles C. Smith, and Abraham L. Brass

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Cotton rat immune responses to virus-like particles containing the pre-fusion form of respiratory syncytial virus fusion protein, Lori McGinnes Cullen, Jorge C. G. Blanco, and Trudy G. Morrison

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TRANSIT - A Software Tool for Himar1 TnSeq Analysis, Michael A. DeJesus, Chaitra Ambadipudi, Richard E. Baker, Christopher M. Sassetti, and Thomas R. Ioerger

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AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity, Sebastian P. Fuchs, Jose M. Martinez-Navio, Michael Piatak Jr., Jeffrey D. Lifson, Guangping Gao, and Ronald C. Desrosiers

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The Epithelial Transmembrane Protein PERP Is Required for Inflammatory Responses to S. typhimurium Infection: A Dissertation, Kelly N. Hallstrom

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Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways, Xing He, Jun Xie, Dongmei Zhang, Qin Su, Xue Sai, Ruipu Bai, Chao Chen, Xufeng Luo, Guangping Gao, and Weiqing Pan

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Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination, Tatenda Kadungure, Anna J. Ucher, Erin K. Linehan, Carol E. Schrader, and Janet Stavnezer

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Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells, Lyne Khair, Richard E. Baker, Erin K. Linehan, Carol E. Schrader, and Janet Stavnezer

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Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria, Karen J. Kieser, Cara C. Boutte, Jemila C. Kester, Christina E. Baer, Amy K. Barczak, Xavier Meniche, Michael C. Chao, E Hesper Rego, Christopher M. Sassetti, Sarah M. Fortune, and Eric J. Rubin

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Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors, Shaoyong Li, Li Zhong, Mengxin Li, Qin Su, Ran He, Qiushi Tang, Dale L. Greiner, Michael A. Brehm, Terence R. Flotte, Christian Mueller, and Guangping Gao

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Murine immune responses to virus-like particle-associated pre- and postfusion forms of the respiratory syncytial virus F protein, Lori McGinnes Cullen, Madelyn R. Schmidt, Sarah A. Kenward, Robert T. Woodland, and Trudy G. Morrison

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Yeast Upf1 Associates With RibosomesTranslating mRNA Coding Sequences Upstream of Normal Termination Codons: A Dissertation, Ei Ei Min

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Protein conformation in a vaccine matters, Trudy G. Morrison

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HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages, Thomas A. Musich, Olivia O'Connell, Maria Paz Gonzalez-Perez, Cynthia A. Derdeyn, Paul J. Peters, and Paul R. Clapham

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Functional Upregulation of alpha4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward, Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D. Gardner, and Andrew R. Tapper

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Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection, Claudio Nunes-Alves, Matthew G. Booty, Stephen M. Carpenter, Alissa C. Rothchild, Constance J. Martin, Danielle Desjardins, Katherine Steblenko, Henrik N. Kløverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, and Samuel M. Behar

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Data from: Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection, Claudio Nunes-Alves, Matthew G. Booty, Stephen Carpenter, Alissa C. Rothchild, Constance J. Martin, Danielle Desjardins, Katherine Steblenko, Henrik Kloverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, and Samuel M. Behar

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A chimeric EBV gp350/220-based VLP replicates the virion B-cell attachment mechanism and elicits long-lasting neutralizing antibodies in mice, Javier Gordon Ogembo, Matthew R. Muraswki, Lori McGinnes, Agapi Parcharidou, Rujapak Sutiwisesak, Timelia Tison, Juan Avendano, Deep Agnani, Robert W. Finberg, Trudy G. Morrison, and Joyce D. Fingeroth

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RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus, Jill Perreira, Aaron Aker, George Savidis, Christopher R. Chin, William M. McDougall, Jocelyn M. Portmann, Paul Meraner, Miles Smith, Motiur Rahman, Richard E. Baker, Annick Gauthier, Michael Franti, and Abraham L. Brass

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Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes, Paul J. Peters, Maria Paz Gonzalez-Perez, Thomas A. Musich, Tiffany A. Moore Simas, Rongheng Lin, Abraham N. Morse, Robin J. Shattock, Cynthia A. Derdeyn, and Paul R. Clapham

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Reversion From Methicillin Susceptibility to Methicillin Resistance in Staphylococcus aureus During Treatment of Bacteremia, Megan K. Proulx, Samantha G. Palace, Sumanth Gandra, Brenda Torres, Susan Weir, Tracy Stiles, Richard T. Ellison III, and Jon D. Goguen

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On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity, Nicholas Renzette, Timothy F. Kowalik, and Jeffrey D. Jensen

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Limits and patterns of cytomegalovirus genomic diversity in humans, Nicholas Renzette, Cornelia Pokalyuk, Laura Gibson, Bornali Bhattacharjee, Mark R. Schleiss, Klaus Hamprecht, Aparecida Y. Yamamoto, Marisa M. Mussi-Pinhata, William J. Britt, Jeffrey D. Jensen, and Timothy F. Kowalik

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Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels, Mandy L. Roberts-Crowley and Ann R. Rittenhouse

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Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts, Charles A. Specht, Chrono K. Lee, Haibin Huang, Donald J. Tipper, Zu T. Shen, Jennifer K. Lodge, John D. Leszyk, Gary R. Ostroff, and Stuart M. Levitz

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Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan, Cara M. Weismann, Jennifer Ferreira, Allison M. Keeler, Qin Su, Linghua Qiu, Scott A. Shaffer, Zuoshang Xu, Guangping Gao, and Miguel Sena-Esteves

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Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment, Konstantin B. Zeldovich, Ping Liu, Nicholas Renzette, Matthieu Foll, Serena T. Pham, Sergey V. Venev, Glen R. Gallagher, Daniel N. Bolon, Evelyn A. Kurt-Jones, Jeffrey D. Jensen, Daniel R. Caffrey, Celia A. Schiffer, Timothy F. Kowalik, Jennifer P. Wang, and Robert W. Finberg

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Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal, Rubing Zhao-Shea, Steven Degroot, Liwang Liu, Markus Vallaster, Xueyan Pang, Qin Su, Guangping Gao, Oliver J. Rando, Gilles E. Martin, Olivier George, Paul D. Gardner, and Andrew R. Tapper

Publications from 2014

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A deterministic model predicts the properties of stochastic calcium oscillations in airway smooth muscle cells, Pengxing Cao, Xiahui Tan, Graham Donovan, Michael J. Sanderson, and James Sneyd

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IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion, Tanay M. Desai, Mariana Marin, Christopher R. Chin, George Savidis, Abraham L. Brass, and Gregory B. Melikyan

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Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour

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Influenza virus drug resistance: a time-sampled population genetics perspective, Matthieu Foll, Yu Ping Poh, Nicholas Renzette, Anna Ferrer Admetlla, Claudia Bank, Hyunjin Shim, Anna Sapfo Malaspinas, Gregory Ewing, Ping Liu, Daniel Wegmann, Daniel R. Caffrey, Konstantin B. Zeldovich, Daniel N. A. Bolon, Jennifer Wang, Timothy F. Kowalik, Celia A. Schiffer, Robert W. Finberg, and Jeffrey D. Jensen

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ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination, Lyne Khair, Jeroen E. J. Guikema, Erin K. Linehan, Anna J. Ucher, Niek G.J. Leus, Colin Ogilvie, Zhenkun Lou, Carol E. Schrader, and Janet Stavnezer

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The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment, Emily M. Mallick, John J. Garber, Vijay K. Vanguri, Sowmya Balasubramanian, Timothy Blood, Stacie Clark, Didier F. Vingadassalom, Christopher Louissaint, Beth A. McCormick, Scott B. Snapper, and John M. Leong

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Macrophages clean up: efferocytosis and microbial control, Constance J. Martin, Kristen N. Peters, and Samuel M. Behar

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In search of a new paradigm for protective immunity to TB, Claudio Nunes-Alves, Matthew G. Booty, Stephen Carpenter, Pushpalatha Jayaraman, Alissa C. Rothchild, and Samuel M. Behar

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Genome-wide mutant fitness profiling identifies nutritional requirements for optimal growth of Yersinia pestis in deep tissue, Samantha G. Palace, Megan K. Proulx, Shan Lu, Richard E. Baker, and Jon D. Goguen

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Dicer expression is essential for adult midbrain dopaminergic neuron maintenance and survival, Xueyan Pang, Eric M. Hogan, Alison Casserly, Guangping Gao, Paul D. Gardner, and Andrew R. Tapper

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Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses, Min Peng, Jenny X. Xie, Anna J. Ucher, Janet Stavnezer, and Sharon B. Cantor

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Smurf2 regulates hematopoietic stem cell self-renewal and aging, Charusheila Ramkumar, Yahui Kong, Sally E. Trabucco, Rachel M. Gerstein, and Hong Zhang