This collection showcases the journal articles and other publications authored by researchers in the Luna Lab in the Department of Cell and Developmental Biology at the University of Massachusetts Medical School.

Submissions from 2013

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Supervillin-mediated Suppression of p53 Protein Enhances Cell Survival, Zhiyou Fang and Elizabeth J. Luna (The Journal of biological chemistry)

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Supervillin Binding to Myosin II and Synergism with Anillin Are Required for Cytokinesis, Tara C. Smith, Peter C. Fridy, Yinyin Li, Shruti Basil, Sneha Arjun, Ryan M. Friesen, John D. Leszyk, Brian T. Chait, Michael P. Rout, and Elizabeth J. Luna (Molecular biology of the cell)

Submissions from 2012

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Supervillin couples myosin-dependent contractility to podosomes and enables their turnover, Ridhirama Bhuwania, Susanne Cornfine, Zhiyou Fang, Marcus Kruger, Elizabeth J. Luna, and Stefan Linder (Journal of cell science)

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Human Genome-Wide Association and Mouse Knockout Approaches Identify Platelet Supervillin as an Inhibitor of Thrombus Formation under Shear Stress, Leonard C. Edelstein, Elizabeth J. Luna, Ian B. Gibson, Molly Bray, Ying Jin, Altaf Kondkar, Srikanth Nagalla, Nacima Hadjout-Rabi, Tara C. Smith, Daniel Covarrubias, Stephen N. Jones, Firdos Ahmad, Moritz Stolla, Xianguo Kong, Zhiyou Fang, Wolfgang Bergmeier, Chad Shaw, Suzanne M. Leal, and Paul F. Bray (Circulation)

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An N-terminal, 830 residues intrinsically disordered region of the cytoskeleton-regulatory protein supervillin contains Myosin II- and F-actin-binding sites, Stanislav O. Fedechkin, Jacob Brockerman, Elizabeth J. Luna, Michail Yu. Lobanov, Oxana V. Galzitskaya, and Serge L. Smirnov (Journal of biomolecular structure and dynamics)

Submissions from 2010

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The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility, Zhiyou Fang, Norio Takizawa, Korey A. Wilson, Tara C. Smith, Anna M. Delprato, Michael W. Davidson, David G. Lambright, and Elizabeth J. Luna (Traffic (Copenhagen, Denmark))

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Novel interactors and a role for supervillin in early cytokinesis, Tara C. Smith, Zhiyou Fang, and Elizabeth J. Luna (Cytoskeleton (Hoboken, N.J.))

Submissions from 2009

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Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency, Jessica Lynn Crowley, Tara C. Smith, Zhiyou Fang, Norio Takizawa, and Elizabeth J. Luna (Molecular biology of the cell)

Submissions from 2007

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Supervillin slows cell spreading by facilitating myosin II activation at the cell periphery, Norio Takizawa, Reiko Ikebe, Mitsuo Ikebe, and Elizabeth J. Luna (Journal of cell science)

Submissions from 2006

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Supervillin modulation of focal adhesions involving TRIP6/ZRP-1, Norio Takizawa, Tara C. Smith, Thomas Nebl, Jessica Lynn Crowley, Stephen J. Palmieri, Lawrence M. Lifshitz, Anka G. Ehrhardt, Laura M. Hoffman, Mary C. Beckerle, and Elizabeth J. Luna (The Journal of cell biology)

Submissions from 2004

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Smooth muscle archvillin: a novel regulator of signaling and contractility in vascular smooth muscle, Samudra S. Gangopadhyay, Norio Takizawa, Cynthia Gallant, Amy L. Barber, Hyun-Dong Je, Tara C. Smith, Elizabeth J. Luna, and Kathleen G. Morgan (Journal of cell science)

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Patellin1, a novel Sec14-like protein, localizes to the cell plate and binds phosphoinositides, T. Kaye Peterman, Yamini M. Ohol, Lisa J. McReynolds, and Elizabeth J. Luna (Plant physiology)

Submissions from 2003

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F-actin and myosin II binding domains in supervillin, Yu Chen, Norio Takizawa, Jessica Lynn Crowley, Sang W. Oh, Cheryl Lynn Gatto, Taketoshi Kambara, Osamu Sato, Xiang-Dong Li, Mitsuo Ikebe, and Elizabeth J. Luna (The Journal of biological chemistry)

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Role of the cytoplasmic domain of the Newcastle disease virus fusion protein in association with lipid rafts, V. Dolganiuc, Lori McGinnes, Elizabeth J. Luna, and Trudy G. Morrison (Journal of virology)

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Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton, Sang W. Oh, Robert K. Pope, Kelly P. Smith, Jessica Lynn Crowley, Thomas Nebl, Jeanne B. Lawrence, and Elizabeth J. Luna (Journal of cell science)

Submissions from 2002

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Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes, Thomas Nebl, Kersi N. Pestonjamasp, John D. Leszyk, Jessica Lynn Crowley, Sang W. Oh, and Elizabeth J. Luna (The Journal of biological chemistry)

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Villin-type headpiece domains show a wide range of F-actin-binding affinities, D. Vardar, A. H. Chishti, B. S. Frank, Elizabeth J. Luna, A. A. Noegel, Sang W. Oh, M. Schleicher, and C. J. McKnight (Cell motility and the cytoskeleton)

Submissions from 2000

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Membrane cytoskeleton: PIP(2) pulls the strings, Thomas Nebl, Sang W. Oh, and Elizabeth J. Luna (Current biology : CB)

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Mutant Rac1B expression in Dictyostelium: effects on morphology, growth, endocytosis, development, and the actin cytoskeleton, S. J. Palmieri, Thomas Nebl, Robert K. Pope, D. J. Seastone, E. Lee, E. H. Hinchcliffe, Greenfield Sluder, D. Knecht, J. Cardelli, and Elizabeth J. Luna (Cell motility and the cytoskeleton)

Submissions from 1999

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Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides, F. Nakamura, L. Huang, Kersi N. Pestonjamasp, Elizabeth J. Luna, and H. Furthmayr (Molecular biology of the cell)

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Domain analysis of supervillin, an F-actin bundling plasma membrane protein with functional nuclear localization signals, J. D. Wulfkuhle, I. E. Donina, N. H. Stark, Robert K. Pope, Kersi N. Pestonjamasp, M. L. Niswonger, and Elizabeth J. Luna (Journal of cell science)

Submissions from 1998

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Merlin differs from moesin in binding to F-actin and in its intra- and intermolecular interactions, L. Huang, E. Ichimaru, Kersi N. Pestonjamasp, X. Cui, H. Nakamura, G. Y. Lo, F. I. Lin, Elizabeth J. Luna, and H. Furthmayr (Biochemical and biophysical research communications)

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F-actin blot overlays, Elizabeth J. Luna (Methods in enzymology)

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Supervillin (p205): A novel membrane-associated, F-actin-binding protein in the villin/gelsolin superfamily, Kersi N. Pestonjamasp, Robert K. Pope, J. D. Wulfkuhle, and Elizabeth J. Luna (The Journal of cell biology)

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Cloning, characterization, and chromosomal localization of human superillin (SVIL), Robert K. Pope, Kersi N. Pestonjamasp, Kelly P. Smith, J. D. Wulfkuhle, C. P. Strassel, Jeanne B. Lawrence, and Elizabeth J. Luna (Genomics)

Submissions from 1995

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Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes, K. Pestonjamasp, M. R. Amieva, C. P. Strassel, W. M. Nauseef, H. Furthmayr, and Elizabeth J. Luna (Molecular biology of the cell)

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Ponticulin plays a role in the positional stabilization of pseudopods, D. C. Shutt, D. Wessels, K. Wagenknecht, A. Chandrasekhar, Anne L. Hitt, Elizabeth J. Luna, and D. R. Soll (The Journal of cell biology)

Submissions from 1994

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Association of the Dictyostelium 30 kDa actin bundling protein with contact regions, M. Fechheimer, H. M. Ingalls, R. Furukawa, and Elizabeth J. Luna (Journal of cell science)

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Ponticulin is the major high affinity link between the plasma membrane and the cortical actin network in Dictyostelium, Anne L. Hitt, J. H. Hartwig, and Elizabeth J. Luna (The Journal of cell biology)

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Ponticulin is an atypical membrane protein, Anne L. Hitt, Tze Hong Lu, and Elizabeth J. Luna (The Journal of cell biology)

Submissions from 1993

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The integral membrane protein, ponticulin, acts as a monomer in nucleating actin assembly, C. P. Chia, A. Shariff, S. A. Savage, and Elizabeth J. Luna (The Journal of cell biology)

Submissions from 1992

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Cytoskeleton--plasma membrane interactions, Elizabeth J. Luna and Anne L. Hitt (Science (New York, N.Y.))

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Diacylglycerol-stimulated formation of actin nucleation sites at plasma membranes, A. Shariff and Elizabeth J. Luna (Science (New York, N.Y.))

Submissions from 1991

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Direct binding of F-actin to ponticulin, an integral plasma membrane glycoprotein, C. P. Chia, Anne L. Hitt, and Elizabeth J. Luna (Cell motility and the cytoskeleton)

Submissions from 1990

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Dictyostelium discoideum plasma membranes contain an actin-nucleating activity that requires ponticulin, an integral membrane glycoprotein, A. Shariff and Elizabeth J. Luna (The Journal of cell biology)

Submissions from 1988

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How actin binds and assembles onto plasma membranes from Dictyostelium discoideum, M. A. Schwartz and Elizabeth J. Luna (The Journal of cell biology)

Submissions from 1987

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F-actin binds to the cytoplasmic surface of ponticulin, a 17-kD integral glycoprotein from Dictyostelium discoideum plasma membranes, L. J. Wuestehube and Elizabeth J. Luna (The Journal of cell biology)

Submissions from 1986

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Junctional plasma membrane domains isolated from aggregating Dictyostelium discoideum amebae, H. M. Ingalls, C. M. Goodloe-Holland, and Elizabeth J. Luna (Proceedings of the National Academy of Sciences of the United States of America)

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Binding and assembly of actin filaments by plasma membranes from Dictyostelium discoideum, M. A. Schwartz and Elizabeth J. Luna (The Journal of cell biology)

Submissions from 1984

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A membrane cytoskeleton from Dictyostelium discoideum. III. Plasma membrane fragments bind predominantly to the sides of actin filaments, C. M. Goodloe-Holland and Elizabeth J. Luna (The Journal of cell biology)

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A membrane cytoskeleton from Dictyostelium discoideum. II. Integral proteins mediate the binding of plasma membranes to F-actin affinity beads, Elizabeth J. Luna, C. M. Goodloe-Holland, and H. M. Ingalls (The Journal of cell biology)

Submissions from 1982

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A stable, high capacity, F-actin affinity column, Elizabeth J. Luna, Y. L. Wang, E. W. Voss Jr., D. Branton, and D. L. Taylor (The Journal of biological chemistry)

Submissions from 1981

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Spectrin promotes the association of F-actin with the cytoplasmic surface of the human erythrocyte membrane, V. M. Fowler, Elizabeth J. Luna, W. R. Hargreaves, D. L. Taylor, and D. Branton (The Journal of cell biology)

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A membrane cytoskeleton from Dictyostelium discoideum. I. Identification and partial characterization of an actin-binding activity, Elizabeth J. Luna, V. M. Fowler, J. Swanson, D. Branton, and D. L. Taylor (The Journal of cell biology)

Submissions from 1979

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Identification by peptide analysis of the spectrin-binding protein in human erythrocytes, Elizabeth J. Luna, G. H. Kidd, and D. Branton (The Journal of biological chemistry)

Submissions from 1978

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Multiple phase equilibria in binary mixtures of phospholipids, Elizabeth J. Luna and Harden M. McConnell (Biochimica et biophysica acta)

Submissions from 1977

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Lateral phase separations in binary mixtures of phospholipids having different charges and different crystalline structures, Elizabeth J. Luna and Harden M. McConnell (Biochimica et biophysica acta)

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The intermediate monoclinic phase of phosphatidylcholines, Elizabeth J. Luna and Harden M. McConnell (Biochimica et biophysica acta)