Predictors of serum dioxin, furan, and PCB concentrations among women from Chapaevsk, Russia
Department of Pediatrics; Department of Cell Biology
Medical Subject Headings
Adult; Aging; Dioxins; Environmental Pollutants; Female; Furans; Humans; Middle Aged; Multivariate Analysis; Polychlorinated Biphenyls; Russia; Young Adult
Dioxins, furans, and polychlorinated biphenyls (PCBs) are persistent and bioaccumulative toxic chemicals that are ubiquitous in the environment. We assessed predictors of their serum concentrations among women living in a Russian town contaminated by past industrial activity. Blood samples from 446 mothers aged 23-52 years were collected between 2003-2005 as part of the Russian Children's Study. Serum dioxin, furan, and PCB concentrations were quantified using high-resolution gas chromatography-mass spectrometry. Potential determinants of exposure were collected through interviews. Multivariate linear regression models were used to identify predictors of serum concentrations and toxic equivalencies (TEQs). The median total PCB concentrations and total TEQs were 260 ng/g lipid and 25 pg TEQ/g lipid, respectively. In multivariate analyses, both total PCB concentrations and total TEQs increased significantly with age, residential proximity to a local chemical plant, duration of local farming, and consumption of local beef. Both decreased with longer breastfeeding, recent increases in body mass index, and later blood draw date. These demographic and lifestyle predictors showed generally similar associations with the various measures of serum dioxins, furans, and PCBs.
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Citation: Environ Sci Technol. 2010 Jul 15;44(14):5633-40. Link to article on publisher's site
Humblet, Olivier; Williams, Paige L.; Korrick, Susan A.; Sergeyev, Oleg; Emond, Claude; Birnbaum, Linda S.; Burns, Jane S.; Altshul, Larisa; Patterson, Donald G. Jr.; Turner, Wayman E.; Lee, Mary M.; Revich, Boris; and Hauser, Russ, "Predictors of serum dioxin, furan, and PCB concentrations among women from Chapaevsk, Russia" (2010). Lee Lab. 5.