Serum adrenal steroid concentrations in premature infants
Department of Pediatrics
Medical Subject Headings
17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; 18-Hydroxycorticosterone; Aldosterone; Androstenedione; Birth Weight; Cortodoxone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Gestational Age; Hormones; Humans; Hydrocortisone; Hydroxyprogesterones; Infant, Newborn; Infant, Premature; Male; Steroids
Cell Biology | Developmental Biology | Endocrinology
To evaluate serum adrenal steroid concentrations in preterm infants, 17-hydroxyprogesterone (17-OHP), 17-hydroxypregnenolone, 11-deoxycortisol, cortisol, dehydroepiandrosterone (DHEA), DHEA sulfate, androstenedione, 18-hydroxycorticosterone, and aldosterone values were determined in 9 sick and 13 healthy premature infants. Serum steroid concentrations were compared to previously reported data from healthy full-term infants. 17-OHP, 11-deoxycortisol, and aldosterone values were higher in sick preterm infants than in healthy preterm infants. Compared to healthy full-term infants, the premature infants-had significantly higher 17-hydroxypregnenolone, 17-OHP, and DHEA sulfate concentrations. Cortisol values were not different between the sick and healthy preterm infants and were similar to full-term values. Aldosterone values were also similar between the premature and the full-term infants. The findings of elevated steroid precursors in preterm infants and low cortisol levels in stressed sick preterm infants may indicate a relative immaturity of adrenal enzyme activity and inadequate adrenal reserve for stress.
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Citation: J Clin Endocrinol Metab. 1989 Dec;69(6):1133-6. Link to article on publisher's site
Lee, Mary M.; Rajagopalan, Lakshmy; Berg, Gregory J.; and Moshang, Thomas Jr., "Serum adrenal steroid concentrations in premature infants" (1989). Lee Lab Publications. 24.