This collection showcases the journal articles and other publications authored by researchers in the Lawrence Lab in the Department of Cell and Developmental Biology at the University of Massachusetts Medical School.

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Publications from 2016

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Regulation of X-linked gene expression during early mouse development by Rlim, Feng Wang, JongDae Shin, Jeremy Shea, Jun Yu, Ana Boskovic, Meg Byron, Xiaochun Zhu, Alex K. Shalek, Aviv Regev, Jeanne B. Lawrence, Eduardo M. Torres, Lihua J. Zhu, Oliver J. Rando, and Ingolf Bach

Publications from 2015

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Spatial re-organization of myogenic regulatory sequences temporally controls gene expression, Akihito Harada, Chandrashekara Mallappa, Seiji Okada, John T. Butler, Stephen P. Baker, Jeanne B. Lawrence, Yasuyuki Ohkawa, and Anthony N. Imbalzano (Nucleic acids research)

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Unfolding the story of chromatin organization in senescent cells, Eric C. Swanson, Lindsy M. Rapkin, David P. Bazett-Jones, and Jeanne B. Lawrence (Nucleus (Austin, Tex.))

Publications from 2014

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Stable C0T-1 repeat RNA is abundant and is associated with euchromatic interphase chromosomes, Lisa L. Hall, Dawn M. Carone, Alvin V. Gomez, Heather J. Kolpa, Meg Byron, Nitish Mehta, Frank O. Fackelmayer, and Jeanne B. Lawrence (Cell)

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RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast, JongDae Shin, Mary C. Wallingford, Judith Gallant, Chelsea Marcho, Baowei Jiao, Meg Byron, Michael Bossenz, Jeanne B. Lawrence, Stephen N. Jones, Jesse Mager, and Ingolf Bach

Publications from 2013

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A multifaceted FISH approach to study endogenous RNAs and DNAs in native nuclear and cell structures, Meg Byron, Lisa L. Hall, and Jeanne B. Lawrence (Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.])

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A long noncoding RNA mediates both activation and repression of immune response genes, Susan Carpenter, Daniel Aiello, Maninjay K. Atianand, Emiliano P. Ricci, Pallavi Gandhi, Lisa L. Hall, Meg Byron, Brian G. Monks, Meabh Henry-Bezy, Jeanne B. Lawrence, Luke A. J. O'Neill, Melissa J. Moore, Daniel R. Caffrey, and Katherine A. Fitzgerald (Science (New York, N.Y.))

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Translating dosage compensation to trisomy 21, Jun Jiang, Yuanchun Jing, Gregory J. Cost, Jen-Chieh Chiang, Heather J. Kolpa, Allison M. Cotton, Dawn M. Carone, Benjamin R. Carone, David A. Shivak, Dmitry Y. Guschin, Jocelynn R. Pearl, Edward J. Rebar, Meg Byron, Philip D. Gregory, Carolyn J. Brown, Fyodor D. Urnov, Lisa L. Hall, and Jeanne B. Lawrence (Nature)

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Interview: from Down's syndrome to basic epigenetics and back again, Jeanne B. Lawrence (Epigenomics)

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Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence, Eric C. Swanson, Benjamin J. Manning, Hong Zhang, and Jeanne B. Lawrence (The Journal of cell biology)

Publications from 2012

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Heterochromatin instability in cancer: From the Barr body to satellites and the nuclear periphery, Dawn M. Carone and Jeanne B. Lawrence (Seminars in cancer biology)

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Paternal RLIM/Rnf12 Is a Survival Factor for Milk-Producing Alveolar Cells, Baowei Jiao, Hong Ma, Maxim N. Shokhirev, Alexander Drung, Qin Yang, JongDae Shin, Shaolei Lu, Meg Byron, Sundeep Kalantry, Arthur M. Mercurio, Jeanne B. Lawrence, Alexander Hoffmann, and Ingolf Bach

Publications from 2011

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The three-dimensional folding of the α-globin gene domain reveals formation of chromatin globules, Davide Bau, Amartya Sanyal, Bryan R. Lajoie, Emidio Capriotti, Meg Byron, Jeanne B. Lawrence, Job Dekker, and Marc A. Marti-Renom (Nature structural and molecular biology)

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XIST RNA and Architecture of the Inactive X Chromosome: Implications for the Repeat Genome, Lisa L. Hall and Jeanne B. Lawrence (Cold Spring Harbor symposia on quantitative biology)

Publications from 2010

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Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus, Hariharan P. Easwaran, Leander Van Neste, Leslie Cope, Subhojit Sen, Helai P. Mohammad, Gayle Jeannette Pageau, Jeanne B. Lawrence, James G. Herman, Kornel E. Schuebel, and Stephen B. Baylin (Cancer research)

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Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice, JongDae Shin, Michael Bossenz, Young Chung, Hong Ma, Meg Byron, Naoko Taniguchi-Ishigaki, Xiaochun Zhu, Jiao Baowei, Lisa L. Hall, Michael R. Green, Stephen N. Jones, Irm Hermans-Borgmeyer, Jeanne B. Lawrence, and Ingolf Bach (Nature)

Publications from 2009

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Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells, John T. Butler, Lisa L. Hall, Kelly P. Smith, and Jeanne B. Lawrence (Journal of cellular biochemistry)

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An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles, Christine Moulton Clemson, John N. Hutchinson, Sergio A. Sara, Alexander W. Ensminger, Archa H. Fox, Andrew Chess, and Jeanne B. Lawrence

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AURKB-mediated effects on chromatin regulate binding versus release of XIST RNA to the inactive chromosome, Lisa L. Hall, Meg Byron, Gayle Jeannette Pageau, and Jeanne B. Lawrence

Publications from 2008

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X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected, Lisa L. Hall, Meg Byron, John T. Butler, Klaus A. Becker, Angel Nelson, Michal Amit, Joseph Itskovitz-Eldor, Janet L. Stein, Gary S. Stein, Carol Ware, and Jeanne B. Lawrence (Journal of cellular physiology)

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Gene associations: true romance or chance meeting in a nuclear neighborhood, Jeanne B. Lawrence and Christine Moulton Clemson

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Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells, Rajini R. Mudhasani, Zhiqing Zhu, Gyorgy Hutvagner, Christine M. Eischen, Stephen Lyle, Lisa L. Hall, Jeanne B. Lawrence, Anthony N. Imbalzano, and Stephen N. Jones

Publications from 2007

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Inducible XIST-dependent X-chromosome inactivation in human somatic cells is reversible, Jennifer C. Chow, Lisa L. Hall, Sarah E.L. Baldry, Nancy P. Thorogood, Jeanne B. Lawrence, and Carolyn J. Brown (Proceedings of the National Academy of Sciences of the United States of America)

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A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains, John N. Hutchinson, Alexander W. Ensminger, Christine Moulton Clemson, Christopher R. Lynch, Jeanne B. Lawrence, and Andrew Chess

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The disappearing Barr body in breast and ovarian cancers, Gayle Jeannette Pageau, Lisa L. Hall, Shridar Ganesan, David M. Livingston, and Jeanne B. Lawrence (Nature reviews. Cancer)

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BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin, Gayle Jeannette Pageau, Lisa L. Hall, and Jeanne B. Lawrence

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Defining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains, Kelly P. Smith, Meg Byron, Carol V. Johnson, Yigong P. Xing, and Jeanne B. Lawrence

Publications from 2006

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The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences, Christine Moulton Clemson, Lisa L. Hall, Meg Byron, John A. McNeil, and Jeanne B. Lawrence

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Molecular anatomy of a speckle, Lisa L. Hall, Kelly P. Smith, Meg Byron, and Jeanne B. Lawrence

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Word frequency analysis reveals enrichment of dinucleotide repeats on the human X chromosome and [GATA]n in the X escape region, John A. McNeil, Kelly P. Smith, Lisa L. Hall, and Jeanne B. Lawrence

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BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin, Gayle Jeannette Pageau and Jeanne B. Lawrence

Publications from 2004

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Ubiquitinated proteins including uH2A on the human and mouse inactive X chromosome: enrichment in gene rich bands, Kelly P. Smith, Meg Byron, Christine M. Clemson, and Jeanne B. Lawrence

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The 4q subtelomere harboring the FSHD locus is specifically anchored with peripheral heterochromatin unlike most human telomeres, Rose Tam, Kelly P. Smith, and Jeanne B. Lawrence

Publications from 2003

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Characterization of expression at the human XIST locus in somatic, embryonal carcinoma, and transgenic cell lines, Jennifer C. Chow, Lisa L. Hall, Christine Moulton Clemson, Jeanne B. Lawrence, and Carolyn J. Brown

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Repositioning of muscle-specific genes relative to the periphery of SC-35 domains during skeletal myogenesis, Phillip T. Moen, Carol V. Johnson, Meg Byron, Lindsay S. Shopland, Ivana L. de la Serna, Anthony N. Imbalzano, and Jeanne B. Lawrence

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Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton, Sang W. Oh, Robert K. Pope, Kelly P. Smith, Jessica Lynn Crowley, Thomas Nebl, Jeanne B. Lawrence, and Elizabeth J. Luna

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Clustering of multiple specific genes and gene-rich R-bands around SC-35 domains: evidence for local euchromatic neighborhoods, Lindsay S. Shopland, Carol V. Johnson, Meg Byron, John A. McNeil, and Jeanne B. Lawrence

Publications from 2002

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An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells, Lisa L. Hall, Meg Byron, Kosuke Sakai, Laura Carrel, Huntington F. Willard, and Jeanne B. Lawrence

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Unbalanced X;autosome translocations provide evidence for sequence specificity in the association of XIST RNA with chromatin, Lisa L. Hall, Christine Moulton Clemson, Meg Byron, Karen L. Wydner, and Jeanne B. Lawrence

Publications from 2001

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Replication-dependent histone gene expression is related to Cajal body (CB) association but does not require sustained CB contact, Lindsay S. Shopland, Meg Byron, Janet L. Stein, Jane B. Lian, Gary S. Stein, and Jeanne B. Lawrence

Publications from 2000

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Tracking COL1A1 RNA in osteogenesis imperfecta. splice-defective transcripts initiate transport from the gene but are retained within the SC35 domain, Carol V. Johnson, Dragan Primorac, Monique B. McKinstry, John A. McNeil, David W. Rowe, and Jeanne B. Lawrence

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Seeking common ground in nuclear complexity, Lindsay S. Shopland and Jeanne B. Lawrence

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Interactions of U2 gene loci and their nuclear transcripts with Cajal (coiled) bodies: evidence for PreU2 within Cajal bodies, Kelly P. Smith and Jeanne B. Lawrence

Publications from 1999

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Processing of endogenous pre-mRNAs in association with SC-35 domains is gene specific, Kelly P. Smith, Phillip T. Moen Jr., Karen L. Wydner, John R. Coleman, and Jeanne B. Lawrence

Publications from 1998

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Stabilization and localization of Xist RNA are controlled by separate mechanisms and are not sufficient for X inactivation, Christine Moulton Clemson, Jennifer C. Chow, Carolyn J. Brown, and Jeanne B. Lawrence

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Cloning, characterization, and chromosomal localization of human superillin (SVIL), Robert K. Pope, Kersi N. Pestonjamasp, Kelly P. Smith, J. D. Wulfkuhle, C. P. Strassel, Jeanne B. Lawrence, and Elizabeth J. Luna

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Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains, Congmei Zeng, Sandra Marie McNeil, Shirwin M. Pockwinse, Jeffrey A. Nickerson, Lindsay S. Shopland, Jeanne B. Lawrence, Sheldon Penman, Scott W. Hiebert, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein

Publications from 1997

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Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors, Congmei Zeng, Andre J. Van Wijnen, Janet L. Stein, Shari Meyers, Wuhua Sun, Lindsay S. Shopland, Jeanne B. Lawrence, Sheldon Penman, Jane B. Lian, Gary S. Stein, and Scott W. Hiebert

Publications from 1996

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X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse, Laura Carrel, Christine Moulton Clemson, John M. Dunn, Andrew P. Miller, Patricia A. Hunt, Jeanne B. Lawrence, and Huntington F. Willard

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Multifunctional compartments in the nucleus: insights from DNA and RNA localization, Christine Moulton Clemson and Jeanne B. Lawrence

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XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure, Christine Moulton Clemson, John A. McNeil, Huntington F. Willard, and Jeanne B. Lawrence

Publications from 1995

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Nonrandom gene organization: structural arrangements of specific pre-mRNA transcription and splicing with SC-35 domains, Yigong P. Xing, Carol V. Johnson, Phillip T. Moen, John A. McNeil, and Jeanne B. Lawrence

Publications from 1994

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Dynamic changes in the higher-level chromatin organization of specific sequences revealed by in situ hybridization to nuclear halos, Michael G. Gerdes, Kenneth C. Carter, Phillip T. Moen, and Jeanne B. Lawrence

Publications from 1993

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Gene expression at single cell resolution associated with development of the bone cell phenotype: ultrastructural and in situ hybridization analysis, Shirwin M. Pockwinse, Jeanne B. Lawrence, Robert H. Singer, Janet L. Stein, Jane B. Lian, and Gary S. Stein (Bone)

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Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13, Cynthia A. Sparks, Peter Lawrence Bangs, Gerard P. McNeil, Jeanne B. Lawrence, and Edward G. Fey

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Higher level organization of individual gene transcription and RNA splicing, Yigong P. Xing, Carol V. Johnson, Paul R. Dobner, and Jeanne B. Lawrence

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Nuclear RNA tracks: structural basis for transcription and splicing, Yigong P. Xing and Jeanne B. Lawrence

Publications from 1992

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The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus, Carolyn J. Brown, Brian D. Hendrich, Jim L. Rupert, Ronald G. Lafreniere, Yigong P. Xing, Jeanne B. Lawrence, and Huntington F. Willard

Publications from 1991

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Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus, Kenneth C. Carter, Krishan L. Taneja, and Jeanne B. Lawrence

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Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein, Mark E. Ewen, Yigong P. Xing, Jeanne B. Lawrence, and David M. Livingston

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Preservation of specific RNA distribution within the chromatin-depleted nuclear substructure demonstrated by in situ hybridization coupled with biochemical fractionation, Yigong P. Xing and Jeanne B. Lawrence

Publications from 1990

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Subcellular localization of low-abundance human immunodeficiency virus nucleic acid sequences visualized by fluorescence in situ hybridization, Jeanne B. Lawrence, Lisa M. Marselle, Kevin S. Byron, Carol V. Johnson, John L. Sullivan, and Robert H. Singer

Publications from 1989

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Detection of HIV-1-infected cells from patients using nonisotopic in situ hybridization, Robert H. Singer, Kevin S. Byron, Jeanne B. Lawrence, and John L. Sullivan

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Ultrastructural visualization of cytoskeletal mRNAs and their associated proteins using double-label in situ hybridization, Robert H. Singer, Gary L. Langevin, and Jeanne B. Lawrence

Publications from 1988

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Intracellular distribution of histone mRNAs in human fibroblasts studied by in situ hybridization, Jeanne B. Lawrence, Robert H. Singer, Carol A. Villnave, Janet L. Stein, and Gary S. Stein